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"It has long been recognized that lymphocyte counts in the human peripheral blood vary according to the time of day (15–19). Both CD4+ and CD8+ T cell counts are rhythmic, with peak levels during the night that decline in the morning and stay low during the day. This is true for naive, effector, and memory CD4+ and for naive CD8+ T cell subsets"
#Immunology #CD8Cells #Tcells #Circadian #Lymphocyte #Review
https://journals.aai.org/jimmunol/article/210/1/12/237594/Regulation-of-Cytotoxic-CD8-T-Cells-by-the
"In nocturnal rodents, lymphocyte counts in the blood are high during the day, which corresponds to the resting phase of these animals. More specifically, CD4+ and CD8+ T cell numbers in the mouse blood are highest at zeitgeber time (ZT)4–5 (beginning of the day) and lowest at ZT16 (beginning of the night) (20, 21)."
https://journals.aai.org/jimmunol/article/210/1/12/237594/Regulation-of-Cytotoxic-CD8-T-Cells-by-the