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Hao Yin

Fantastic story
AT1- crosstalk in Lung 🤠

Hopx+ AT1 Vegfa KO->
Loss of Car4+ EC ramifying over Alveoli
w/o reduced PLVAP+ capillary EC->
Alveolar Smoothening (⏬Outpocketing?)🧐

Dr. Jichao Chen lab Dev Cell 2020
cell.com/developmental-cell/fu

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Hao Yin

Arterial dissections: Common features and new perspectives

A comprehensive review covering diverse arterial beds

Biomechanics
+ plasticity
Genetics
TGFβ, ECM

Dr. Robert Graham lab Frontiers Cardiovascular Medicine 2022
frontiersin.org/articles/10.33

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Hao Yin

Mouse Lung Spliceomic e15.5-P8

Enriched pathways Junctions; Hippo

Novel VEGFA splice variant
VEGFA i5😎

AT1 as a major lung cell for VEGFA expression & alternative splicing

VEGFA-188 (not -164) promote Car4+ specification

Dr. Francisca Vasconcelos & Cláudio Franco labs, Life Science Alliance 2022
life-science-alliance.org/cont

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Hao Yin

Lung Heterogeneity & Proliferation post H1N1 injury

EC subpopulation 14 dpi trajectory (Slingshot)
Ligand-receptor analysis (FANTOM5)->
AT1-to-Car4-hi EC signaling in

Dr. Edward E Morrisey lab @eLife 2020
elifesciences.org/articles/530

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Hao Yin boosted
Mingqing Cai :verified:

Is there a quick button to click/hide those toots I read? That way I only need to focus on those unread ones next time I get online.

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Hao Yin

Stabilizing FOXF1 to treat

Chemical screening->TanFe
⏬Ubiquitination of FOXF1 via⏬binding to HECTD1/SHPRH/NEURL1B etc->

Restoring Lung of Foxf1+/-🐭

Dr. Vladimir Kalinichenko lab Am J Respir Crit Care Med 2022
atsjournals.org/doi/10.1164/rc

How FOXF1 impacts ?

As a transcription factor for S1PR1 & VE-Cad😎

An excellent story from Dr. Vladimir Kalinichenko lab @scisignal 2016👇

FOXF1 maintains endothelial barrier function and prevents edema after lung injury

science.org/doi/10.1126/scisig

Alveolar Capillary Dysplasia with Misalignment of Pulmonary Veins, due to FOXF1 heterozygous mutation, has very complex Lung & ex-Lung vascular phenotypes

A few reads🤠

diagnosticpathology.biomedcent

nature.com/articles/jp201494

nature.com/articles/ejhg201217

jpeds.com/article/S0022-3476(0

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Hao Yin

Aberrant Mechanical tension-activated TGFβ1-SMAD2/3 signaling, synergized with Cdc42 deficiency, in AT2 alveolar cells causes peripheral-to-center progression in🐭post-lung lobe resection

Dr. Jingyu Chen & Nan Tang labs @cellpress 2019
cell.com/cell/fulltext/S0092-8

Interesting, ablation of TGFβR2 in Cdc42 KO AT2 cells blunts fibrotic expansion w/o rescuing

In contrast, Normalizing the ectopic mechanical tension post-lung lobe resection, using a unique silicon prosthesis, rescues both alveolar regeneration & fibrosis

How Cdc42 controls AT2 cell mechanosensitivity & plasticity during ?

A Cdc42-F-actin-JNK/p38-YAP cascade

A very cool paper🤠👇

Dr. Nan Tang lab @CellReports 2016
cell.com/cell-reports/fulltext

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Hao Yin

Single-cell Transcriptomic Atlas of human Lung

75k cells
58 molecular types: 15 epithelial, 9 endothelial, 9 stromal, 25 immune
7 tissue blocks
1♀️+2♂️

17/58👤molecular types absent in🐭 Lung

Dr. Stephen Quake & Mark Krasnow labs @Nature 2020
nature.com/articles/s41586-020

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Hao Yin

AT1 cell Plasticity in & Lung Homestasis+Regeneration

AT1 contributes to 30% & 10% AT2 in neonatal & adult 🐭Hyperoxia Lung injury👹

TAZ (likely > ) maintains adult AT1 lineage identity Fig 6E

Dr. David Frank & Edward Morrisey Labs @CellStemCell 2021
cell.com/cell-stem-cell/fullte

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Hao Yin

Vinculin-α-Catenin complex⏫ Barrier during vascular morphogenesis

Vinculin a/b deficient🐟 48hpf->
Enhanced Permeability of 10 kD (not 70 kD) dextran of DLAV & ISV, but not dorsal aorta

Dr. Stephan Huveneers lab Vascular Biology 2022
vb.bioscientifica.com/view/jou

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Hao Yin

Causal role of in 🤠

i.v. Delivery of E4ORF1-transduced Lung
Or EC LRG1 (TGFβ/Alk1/Eng modulator) KO
alleviates elastase-induced🐭COPD

Dr. Alexandra Racanelli, Shahin Rafii & Augustine Choi labs J Exp Med 2021
rupress.org/jem/article-standa

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Hao Yin

Damage-associated transient progenitor in

Lung Organoid+ multi reporter🐭->
Lineage trajectory of AT2 cells of bleomycin lung injury🤠

ILβ-primed AT2->
Cldn4+Ndrg1+Krt8+Ly6a+ bipotent DATP->
AT1

Dr. Joo-Hyeon LeeLab @CellStemCell 2020
cell.com/cell-stem-cell/fullte

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Hao Yin

ATF3+ lung capillary proliferates & promotes post H1N1 injury

🫁ATF3 KO EC 14 dpi->
⏬Proliferation
⏫Apoptosis
Altered Angiogcrine🤠🧐 to⏬AT1+AT2 epithelial cells

Dr. Edward E. Morrisey lab bioRxiv 2022
biorxiv.org/content/10.1101/20

Reminiscent of the really cool work from Dr. Katrien De Bock @cell_metabolism 2021

ATF3/4+ Capillary , preferably surrounding oxidative myofibers, as a major cellular origin of Exercise-induced 😎

sciencedirect.com/science/arti

0
Hao Yin

Spatial Atlas of human Lung

Spatially-resolved multi-omics-> -associated Lymphoid niche for IgA + T cells via CCL28/IL6/APRIL paracrine

5 locations, 13 patients

Systemic vs Pulmonary vascular trees

Immune recruiting venous NG2-ABCC9+ICAM1+ is abundant in CCL2/19/21 & CXCL12🤠

Love to dig into transcriptomes of systemic vs pulmonary & pericytes along the bronchial tree😋

A spatially resolved atlas of the human lung characterizes a gland-associated immune niche

Love this powerful molecular micro-anatomy for human Lung👍

A great starting point for my Holiday-specific continued biomedical education on Lung🎄

Dr. Sarah Teichmann & Kerstin Meyer lab Nature Genetics 2022
nature.com/articles/s41588-022

0
Hao Yin

Bioelectrical initiation of HeartBeat👹

"a noisy saddle-node on invariant circle bifurcation as the critical phase transition that starts the heart"

A wild & cool piece from Dr Sean Megason & Adam Cohen labs bioRxiv 2022 @SeanMegason @AdamEzraCohen
biorxiv.org/content/10.1101/20

Also do not miss this great thread from 1st Author @BillZJia
twitter.com/BillZJia/status/16

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Hao Yin

Tumor spheroid-microvasculature-on-a-chip


0.6×0.3×25 mm
5 & 15 dyn/cm2
MCF-7 spheroid
HUVEC monolayer

Tumor spheroid alters polarization to shear🤠

Sheared EC⏬spheroid growth🤠🤠

Dr. Hongxu Lu & Lining Arnold Ju labs bioRxiv 2022
biorxiv.org/content/10.1101/20

0
Hao Yin

Vascular : from pathogenesis to treatment

Superficial & deep vein Thrombosis in 50% patients

Arterial involvement
Thrombosis+Aneurysm of abdominal aorta, pulmonary artery, peripheral arteries

Wait for more human Genetics for this still-mysterious disease 🧐

Dr. Giacomo Emmi lab Nat Rev Rheumatol 2022
nature.com/articles/s41584-022

0
Hao Yin boosted
Joachim Goedhart

Nice work on Single-cell dynamics of core pluripotency factors in human pluripotent stem cells. Cells were expressing OCT4-mCherry, SOX2-mTurquoise2, or NANOG-mVenus:
biorxiv.org/content/10.1101/20

0
Hao Yin

5-channel (separated by microposts) for - fibrin-
collagen co-culture

Human Lung fibroblast as feeder

Enable study of Synergy b/w & Pericyte on 😁

Dr. Ryuji Yokokawa lab, Lab on a chip 2022

0
Hao Yin

Innervation of by branching

72 calves from 12♀️+24♂️donors

An anatomical basis for improving sympathectomy strategy to treat

Dr. Yun Xie & Xiao-Zhen Zhao labs Clin Anat 2022
onlinelibrary.wiley.com/doi/ab

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