Hao Yin @HaoYin@qoto.org
Cardiovascular biologist, Dr. J. Geoffrey Pickering lab, Robarts Research Institute, Western University, London, Ontario, Canada
https://scholar.google.ca/citations?hl=en&user=IbrDx00AAAAJ&view_op
Joined Nov 2022
MEG9/Mirg, a LncRNA in Dlk1-Dio3 cardio-angiocluster, links #DNADamage & #Angiogenesis
⏫by Genotoxic stress
⏬by VEGF/FGF2/Dll4/Jag1
🐭Mirg KO affects s.c. Matrigel vessel stability in a Sex-specific manner
Dr. Cristina Espinosa-Diez & Sudarshan Anand lab bioRXiv 2022
https://www.biorxiv.org/content/10.1101/2022.12.07.519382v1
#Leiomyoma with Bizarre Nuclei: A Current Update
Review on Uterine Smooth Muscle Tumors😎
Pathology & MRI
Differentiating LBN from
other Leiomyoma
USMT of uncertain malignant potential Leiomyosarcoma
Dr. Q Zheng & L Wang labs Int J Womens Health 2022
https://www.dovepress.com/leiomyoma-with-bizarre-nuclei-a-current-update-peer-reviewed-fulltext-article-IJWH
Sirt6⏬#Senescence & IL15-JAK3-STAT5-inflammation in adult #Chondrocyte
Deacetylated STAT5 by Sirt6 fails nuclear import
In contrast, Sirt6⏫p21->Senescence in embryonic chondrocyte
Dr. Ming-liang Ji & Jun Lu lab Nature Comms 2022
https://www.nature.com/articles/s41467-022-35424-w
An interesting chondrotrophic nanoparticle is used to deliver MDL-800, Sirt6 activator, in🐭DMM #Osteoarthritis
Chondrocyte-specific aptamer tgg2-functionalized PEGylated PAMAM nanoparticle
Originally used for microRNA Annals of the Rheumatic Diseases 2021
https://ard.bmj.com/content/80/3/356.abstract
Hao Yin
boosted
RT @lucasmpinto
Please RT. My graduate student Peter Salvino @petersalvino has been missing since last night. Last seen in Lincoln Park, Chicago. See below. Please get in touch if you have any info
Hao Yin
boosted
Vascularization improves function performance of #hiPSC-β Islet #Organoid 🤠
Ca2+ as a surrogate for insulin secretion to high throughput screening
A role of #Angiocrine #BMP4 signaling & #BasementMembrane
Dr. Maike Sander lab bioRxiv 2022
https://www.biorxiv.org/content/10.1101/2022.10.28.513298v1.full
Hao Yin
boosted
I'm excited about this new #genomics #scRNA #rnaseq preprint from @ariel_hippen! It's a molecular biology deep dive into what happens when you dissociate and single-cell sequence a tissue with the goal of performing deconvolution of bulk tissue.
Some key bits: there are dissociation effects, RNA capture/depletion effects, and potentially some microfluidics effects with the #10X platform. Also, deconvolution algorithms are variably robust to these things.
See more:
https://www.biorxiv.org/content/10.1101/2022.12.04.519045v1
The lysosomal degraders
#PROTAC +derivatives
An update on Research & Commercialization of #MolecularGlue for targeted protein degradation
"LYTACs, ATACs, AbTACs, KineTACs, PROTABs, AUTACs, ATTECs and AUTOTACs"
Ken Garber Nature Biotech 2022
https://www.nature.com/articles/s41587-022-01594-7
#Mechanobiology🐭 Heart #Valvulogenesis
Spatiotemporal YAP nuclear patterning in Valvular Endothelium+Interstitium correlates with in vivo force transition
⏬by #LaminarShearStress
⏫by OSS
⏫by #CompressiveStress
⏬by #TensileStress
Jonathan Butcher Lab bioRxiv 2022
https://www.biorxiv.org/content/10.1101/2022.11.24.517814v1.full
Hao Yin
boosted
RT @G_Charras
How do cells orient their division within the epithelial plane?
We find that a sufficiently large tension at junctions is required for accurate in plane division.
https://doi.org/10.1073/pnas.2201600119
Great work by @ana_lisica @jduquell @alebonfanti_ab @womtyatt @manasikelkar09 @BaumBuzz
Pathogenesis of #GiantCellArteritis with focus on cellular populations
Immune+Stromal cell dynamics
Cytokine signature
IL6-IL17
IL12-IFNγ
Immune Checkpoint
Immunosenescence
This is a very friendly review for a non-immunologist (me😄)
Dr. Pavlos Stamatis lab Front Medicine 2022
https://www.frontiersin.org/articles/10.3389/fmed.2022.1058600/full
An autosomal (Chr2) Myh11-CreERT2🐭model to enable #SmoothMuscleCell-specific KO & lineage tracing in Both MALE & FEMALE!👍
Previous mouse Myh11-Cre transgenes are Y-linked
Dr. Gary Owens lab ATVB 2022
https://www.ahajournals.org/doi/10.1161/ATVBAHA.122.318160
#4DFlowMRI to image Left Ventricle flow components & LA-LV local pressure in #BicuspidAorticValve with mild #AorticRegurgitation + preserved ejection fraction
51 BAV vs 24 Ctrl
Dr. Julio Garcia lab Front Carduivasc Medicine 2022
https://www.frontiersin.org/articles/10.3389/fcvm.2022.903277/full
Hao Yin
boosted
RT @rulandsgroup
Lineage tracing experiments are often compromised by the merging and fragmentation of clones. Together with @YitengDang we wrote a review summarising statistical strategies to detect and resolve such non-clonality. https://www.frontiersin.org/articles/10.3389/fcell.2022.1054476/full
Hao Yin
boosted
RT @YEN_community
📢 Save the date! 📢 #YEN2023 will be a hybrid event at @thecrick on the 22nd of May 2023. We are thrilled to have @kaessmannlab @PauliGroup @Mad_Lancaster and #KatsuhikoHayashi as invited speakers. More details soon http://www.youngembryologists.org/ 😊
Take a look at this amusing repair of 2-photon vessel injury by 2 adjacent #EndothelialCells
Dr Karen Hirschi & Valentina Greco labs bioRxiv 2022
https://www.biorxiv.org/content/10.1101/2022.11.02.514907v1.full
Diabetic Retinal Vasculopathy in #Zebrafish
5%-0% glucose alternating per 12 h for 30 d
⏫Vessel diameter
⏬ZO-1 tight junction
⏬SM22α+ mural cell coverage
Changes in other vascular beds?🧐
Dr. Cheol-Hee Kim & Seung-Hyun Jung labs IJMS_MDPI 2022
https://www.mdpi.com/1422-0067/23/23/15069⏬
IL-1β & Macrophage-like #SmoothMuscleCell/SMC-derived #FoamCell
scRNAseq👤calcified #Atherosclerosis (proximal vs core)->
Ligand-SMC receptor map + Mɸ-like SMC transcription network->
⏫IL1β-⏬STAT3
AAV9-Cas9-sgIL1β for🐭
Dr. Suxin Luo lab Comms Bio 2022
https://www.nature.com/articles/s42003-022-04255-2
Hao Yin
boosted
Focal adhesions help endothelial cells get in line
A Research Highlight showcasing new work from Tevin Chau, Anne Lagendijk and colleagues
https://journals.biologists.com/dev/article/149/23/e149_e2302/285925/Focal-adhesions-help-endothelial-cells-get-in-line
We interviewed the authors of the paper, Tevin Chau and Anne Lagendijk, for our 'The people behind the papers' series.
https://journals.biologists.com/dev/article/149/23/dev201441/285916/The-people-behind-the-papers-Tevin-Chau-and-Anne
Read the full #OpenAccess Research Article, ‘Dynamically regulated focal adhesions coordinate endothelial cell remodelling in developing vasculature’ here: https://journals.biologists.com/dev/article/149/23/dev200454/285926/Dynamically-regulated-focal-adhesions-coordinate
Hao Yin
boosted
Smoking and progressive retinal nerve fibre layer thinning in glaucoma
https://bjo.bmj.com/content/early/2022/09/13/bjo-2022-321237
Cardiovascular biologist, Dr. J. Geoffrey Pickering lab, Robarts Research Institute, Western University, London, Ontario, Canada
https://scholar.google.ca/citations?hl=en&user=IbrDx00AAAAJ&view_op
Joined Nov 2022
