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Hao Yin boosted

New insights on pancreatic morphogenesis from @ondinecleaver@ lab!

Another link between #morphogenesis and #differentiation!

Pre-print 🔗
qoto.org/@biorxivpreprint/1093

Hao Yin boosted

Airway Inflammation

SMMHC-driven α7 transgene in ovalbumin♀️🐭->
⏬Airway leukocyte infiltration
⏬Pulmonary resistance (not compliance)
Re-balanced cytokine/chemokine production

Dr. Mariam Ba lab FASEB Bioadv 2022
faseb.onlinelibrary.wiley.com/

Some encode functional peptides😎

LncPSR & its protein, Arteridin, complex with Ybx1->
contractile phenotype

AAV2-SM22α-shPSR⏬ANGII-induced SMC hypertrophy in🐭aorta

Dr. Y Wang, G Wu, C Zeng labs @CircRes 2022
ahajournals.org/doi/10.1161/CI

😎

50% tetrahydrofuran in ddH2O to clear🐭🧠etc ≤ 48 h
80% Nycodenz+7M urea-> RI 1.518
Post-clearing cryosectionable, whole-mount immunofluorescence
Minimal volume change

Dr Chih-Wei Hsu & Joshua Wythe labs eLife 2022 @CWLoganHsu @wythelab
elifesciences.org/articles/774

Landmark👹

How fetal liver vasculature serves as a transient niche for expansion while undergoing

Fetal liver hematopoietic stem cell niches associate with portal vessels

Dr. Paul Frenette lab Science 2015
science.org/doi/10.1126/scienc

Hao Yin boosted

Thrilled to share our lab's first paper in which we establish genome-wide CRISPR screening within a single mouse! We are so excited about the power of this platform to enable high-throughput genetic dissection of diverse phenomena within a living mammal.

cell.com/cell-genomics/fulltex


Next-gen

activates CD8+ T cytotoxicity against (inflammed🔥) PD-L1+ senescent cells->
⏬adverse phenotypes in🐭+

Dr. Yoshikazu Johmura & Makoto Nakanishi labs Nature 2022
nature.com/articles/s41586-022

Hao Yin boosted

~50% Olig2+ Progenitors migrate along blood vessel in prenatal🧠cortex🤠

Vessel-guided migration favors superficial cortex as Astrocyte destination

CXCL12-> AP CXCR4/7

Dr. Hidenori Tabata & Kazunori Nakajima labs Nat Comm 2022
nature.com/articles/s41467-022

Pulmonary

Hypoxia
6 dyn/cm2
Patient ECFC+HPASMC co-culture

BMPR2-Sox17->
Prostacyclin production->
proliferation

Comparative transcriptomics vs PAH gene sets

Dr. Beata Wojciak-Stothard lab Communications Biology 2022
nature.com/articles/s42003-022

Hao Yin boosted
Hao Yin boosted

35.5 mile bike today 🚴‍♀️🚴🚴‍♂️Not bad!

Antigen-presenting

PDGFRβ+ Pericyte MHCII KO->
In vitro
⏬CD4+ T cell proliferation & activation

In🐭adoptive transfer EAE
⏫CD3+ T cell entry
No change in BBB, CD4+ T cell, Mɸ, cytokine

Dr. Luisa Klotz lab @IJMS_MDPI 2022
mdpi.com/1422-0067/23/21/13081

Hao Yin boosted

#introduction Hi everyone, I am a developmental biologist, working at the IBDM (Developmental Biology Institute of Marseille) (CNRS and Aix Marseille University). I study muscle development and regeneration, trying to decipher the dysfunctional mechanisms underlying muscle pathologies. I would post with any new equivalent of the very useful #MyoTwitter

Landmark re-read😋

in the development of

"Cavernomas are composed of clones of Ccm3−/− cells that attract Ccm3+/+ cells"

Dr. Matteo Malinverno & Elisabetta Dejana lab Nature Comms 2019
nature.com/articles/s41467-019

Hao Yin boosted

Let’s start a thread with all our: #DevBio #DevBiol #science peeps. Please add more below to help us find everybody! Who are your DevBio friends? We need to post to make this place more vibrant:
@DenisDuboule
@opourquie
@mads100tist
@RogersLabUCD
@HaoYin
@scottbarolo
@kkroll
@SpagnoliLab
@Mill_lab
@jamesbriscoe
@MokalledLab
@AaronJohnson
@ebardot

Hao Yin boosted

Want Mastodon to become more interesting?
1. Connect with other #DevBio #DevBiol peeps here.
2. Post. It’s up to us to start talking.
3. Tell us about who we should follow (not all accounts visible on the follow lists of others, if on different servers).

Hao Yin boosted

@ondinecleaver2022 @DenisDuboule @opourquie @mads100tist @RogersLabUCD @HaoYin @scottbarolo @kkroll @SpagnoliLab @jamesbriscoe @MokalledLab @AaronJohnson @ebardot
Most excellent :ld: :lb: community wrangling Ondine! Little trick to filter is to make a #DevBio list- it is a little cumbersome as everyone and their instance needs to be individually searched and added, but then if you click on your list- posts only from those DB 'Mamoots' will appear. It can help focus from the other noise.

Hao Yin boosted

@ondinecleaver2022 @DenisDuboule @opourquie @RogersLabUCD @HaoYin @scottbarolo @kkroll @SpagnoliLab @Mill_lab @jamesbriscoe @MokalledLab @AaronJohnson @ebardot Ondine, we could pull the followers and followed by the Twitter SDB account and have it as a CSV file people can use to merge their follows. What do you think?

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