Joram Mooiweer @JoramMooiweer@qoto.org
Celiac disease | Mucosal immunology | iPSCs, Intestinal Organoids, T cells & organs-on-chips🔬
PhD-candidate Genetics dept. 🧬 University Medical Center Groningen,
the Netherlands
Joined Nov 2022
Joram Mooiweer
boosted
Joram Mooiweer
boosted
Tools for off- the-shelf CARTs:
"Conventional CRISPR-Cas nucleases install sequence-specific DNA double-strand breaks (DSBs), enabling gene knock-out (KO) or targeted transgene knock-in (KI). However, simultaneous DSBs provoke a high rate of genomic rearrangements which may impede the safety of the edited cells. Here, we combine a non-viral CRISPR-Cas9 nuclease-assisted KI and Cas9-derived base editing technology for DSB free KOs within a single intervention."
For finding and connecting with scientists an #introduction may be convenient:
I’m a PhD candidate at the dept of Genetics of the University Medical Center Groningen/University of Groningen, the Netherlands.
Im interested in the intestinal mucosa and to establish an advanced model of the small intestine. For this I use #iPSCs, #organoids, patient’s cells and #organ-on-chip technology. With this I research #celiacdisease and how the auto-inflammatory response in the small intestine manifests.
Joram Mooiweer
boosted
POLL: If you've been on #Mastodon for over a week and used it each day, how likely are you to go back to using Twitter on a regular basis?
Boost for a larger sample size please.
Real-time imaging of enteric pathogens invading a gut-on-a-chip and evaluating how peristalsis facilitates this. By research from @PasteurEdu
#organonchip #mechanobiology
Joram Mooiweer
boosted
Hello everyone - I am Hugo Mouquet - PhD, molecular #immunologist & head of the humoral immunology lab @ Institut Pasteur - Our lab investigates #antibodies and B-cell responses to viral pathogens in humans | #HIV, #hepatitis #viruses, #SARSCoV2, #chikungunya & more...
Joram Mooiweer
boosted
Now in #Science magazine (@sciencemagazine)
Katherine Freitas, Julia Belk, Ansu Satpathy, Crystal Mackall, & colleagues use #CRISPR screen to identify MED12 & CCNC as key regulators of human #TCell activation & function. Inactivation in #CART cells leads to increased T cell expansion, #metabolic fitness, & #tumor control!
bit.ly/Sci_abn5647
Be sure to also check out the accompanying Perspective by Caitlin Zebley & Ben Youngblood:
Joram Mooiweer
boosted
#introduction I am an #immunologist at the #universityoftoronto. I study how our #mucosal immune system can influence our health, especially brain health. I love constructive discussions about science and how to make #academia a better place for everyone. I love #cooking, #gardening, #singing, #canoeing and learning from my 2 sons. Oh and my 3 @Cats too.
Celiac disease | Mucosal immunology | iPSCs, Intestinal Organoids, T cells & organs-on-chips🔬
PhD-candidate Genetics dept. 🧬 University Medical Center Groningen,
the Netherlands
Joined Nov 2022
