Joram Mooiweer boosted
François Renaville 🇺🇦🇪🇺

EU ready to back immediate #openaccess without author fees - Research Professional News

👉 "The #EU is ready to agree that immediate open access to papers reporting publicly funded #research should become the norm, without authors having to pay fees, and that the bloc should support non-profit scholarly #publishing models." 👍💪

researchprofessionalnews.com/r

#scholcomm #APCs #science #openscience #journals

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Joram Mooiweer boosted
Sicco de Knecht

You've probably already seen it but hey, perhaps a deeper dive is valuable. The entire editorial board (40+ academics) resigns from Elsevier's NeuroImaging and starts a new non-profit OA journal: Imaging Neuroscience.

'Flipping' a journal isn't that common but it sure has an impact.

imaging-neuroscience.org/Annou

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Joram Mooiweer boosted
Dan Mucida

(Thread)

1/ What is the physiological impact of dietary proteins on steady-state T cells? Nelson Vaz and Ana Faria, my undergrad mentors, wondered about this question for decades.

biorxiv.org/content/10.1101/20

Dietary protein shapes the profile and repertoire of intestinal CD4+ T cells

The intestinal immune system must tolerate food antigens to avoid allergy, a process requiring CD4+ T cells. Combining antigenically defined diets with gnotobiotic models, we show that food and microbiota distinctly influence the profile and T cell receptor repertoire of intestinal CD4+ T cells. Independent of the microbiota, dietary proteins contributed to accumulation and clonal selection of antigen-experienced CD4+ T cells at the intestinal epithelium, imprinting a tissue specialized transcriptional program including cytotoxic genes on both conventional and regulatory CD4+ T cells (Tregs). This steady state CD4+ T cell response to food was disrupted by inflammatory challenge, and protection against food allergy in this context was associated with Treg clonal expansion and decreased pro-inflammatory gene expression. Finally, we identified both steady state epithelium-adapted CD4+ T cells and tolerance-induced Tregs that recognize dietary antigens, suggesting that both cell types may be critical for preventing inappropriate immune responses to food. ### Competing Interest Statement The authors have declared no competing interest.

www.biorxiv.org
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Joram Mooiweer boosted
Auscandoc

science.org/doi/10.1126/scienc “Engineered #StaphEpidermidis generated #tumor-specific #Tcells that infiltrated and reduced the growth of localized and metastatic #melanoma. In combination with immune checkpoint inhibitors, these engineered skin bacteria caused mice to reject established tumors. These findings suggest that immune responses from engineered commensals may have therapeutic potential against other tumor antigens of interest.”

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Joram Mooiweer boosted
Thiago Carvalho

Gut tregs:

"Thus, Helios+ effector tTregs proliferate via CD28 and require neither ICOS nor MHCII for maintenance. In contrast, RORγt+ pTregs utilize CD28 and ICOS."

cc @mucida

mucosalimmunology.org/article/

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Joram Mooiweer

Meeting inspirational people makes so much difference!

Just got back home in the Netherlands. Had an amazing time at the combined Keystone Symposia on Molecular & Cellular Biology meeting and visiting the Robert Barrett lab at Cedars Sinai Medical Center, LA.

It is incredible to have met and talked to so many fantastic scientists during this trip. The way this meeting and visit helped to get inspiration, make new connections and reinforce existing collaborations is incomparable. Heading back to the lab with renewed excitement!

Now back to work: I've got a thesis to finish.

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Joram Mooiweer

Just 2 days until Keystone Symposia on Stem cell applications & Organoid disease models in Colorado.

Very, very excited to join this meeting. If you’re there, let’s meet!☕️
Looking forward to talk about the work of our team on patient-derived immunocompetent cultures, intestinal organoids and tissue-chips to model intestinal inflammation.

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Joram Mooiweer boosted
Dan Mucida

RT @Masopust_Vezys
Authored by Andrew G. Soerens et al, we show that are capable of proliferating in response to iterative stimulation for over 10yrs! And produce enough progeny to occupy a volume 30,000x the Earth's volume! @Nature nature.com/articles/s41586-022

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Joram Mooiweer

@zpneal@mastodon.social
Not exactly what you mean, but community peer-review was able to evaluate preprints equally to (High IF) scientific journals:

biorxiv.org/content/10.1101/20

The Preprint Club - A cross-institutional, community-based approach to peer reviewing

The academic community has been increasingly using preprints to disseminate their latest research findings quickly and openly. This early and open access of non-peer reviewed research warrants new means from the scientific community to efficiently assess and provide feedback to preprints. Yet, most peer review of scientific studies performed today are still managed by journals, each having their own peer review policy and transparency. However, approaches to uncouple the peer review process from journal publication are emerging. Additionally, formal education of early career researchers (ECRs) in peer reviewing is rarely available, hampering the quality of peer review feedback. Here, we introduce the Preprint Club, a cross-institutional, community-based approach to peer reviewing, founded by ECRs from the University of Oxford, Karolinska Institutet and Icahn School of Medicine at Mount Sinai. Over the past two years and using the collaborative setting of the Preprint Club, we have been discussing, assessing, and providing feedback on recent preprints in the field of immunology. In this article, we provide a blueprint of the Preprint Club basic structure, demonstrate its effectiveness, and detail the lessons we learned on its impact on peer review training and preprint author's perception. ### Competing Interest Statement The authors have declared no competing interest.

www.biorxiv.org
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Joram Mooiweer

@drtifftaft Absolutely! 😊

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Joram Mooiweer boosted
Anshul Kundaje

RT @svpino@twitter.com

11 ways ChatGPT saves me hours of work every day, and why you'll never outcompete those who use AI effectively.

A list for those who write code:

1 of 16

🐦🔗: twitter.com/svpino/status/1611

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Joram Mooiweer

@MarkHanson My reaction exactly!

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Joram Mooiweer

Since the peer-review experiment failed, this sounds like the right alternative:
Pre-print peer review by the scientific community.

Love the idea and apparently works pretty well!

biorxiv.org/content/10.1101/20

The Preprint Club - A cross-institutional, community-based approach to peer reviewing

The academic community has been increasingly using preprints to disseminate their latest research findings quickly and openly. This early and open access of non-peer reviewed research warrants new means from the scientific community to efficiently assess and provide feedback to preprints. Yet, most peer review of scientific studies performed today are still managed by journals, each having their own peer review policy and transparency. However, approaches to uncouple the peer review process from journal publication are emerging. Additionally, formal education of early career researchers (ECRs) in peer reviewing is rarely available, hampering the quality of peer review feedback. Here, we introduce the Preprint Club, a cross-institutional, community-based approach to peer reviewing, founded by ECRs from the University of Oxford, Karolinska Institutet and Icahn School of Medicine at Mount Sinai. Over the past two years and using the collaborative setting of the Preprint Club, we have been discussing, assessing, and providing feedback on recent preprints in the field of immunology. In this article, we provide a blueprint of the Preprint Club basic structure, demonstrate its effectiveness, and detail the lessons we learned on its impact on peer review training and preprint author's perception. ### Competing Interest Statement The authors have declared no competing interest.

www.biorxiv.org
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Joram Mooiweer boosted
Leon Lotter

On #scienceTwitter, my favourite thing were reading and, on rare occasions, writing "paper/preprint threads". From the researchers I followed and through the #Twitter algorithm, this became my most important source for new #research.

While people start to do the same on #Mastodon, I have the feeling that I miss important work bc no algorithm "saves" it for me if I don't watch my timeline constantly.

Two simple solutions would be: a commonly accepted hashtag that everybody uses when writing "paper threads" or a [...] @ a.gup.pe group with a similar adaptation rate.

#Question 1: is there already a mechanism for this that I missed?
#Question 2: What hashtag or group name?
I saw #TootPrint before. Maybe #PaperInAToot? #PaperInAPost? #PaperInAThread? #PaperPost? #MastoPrint?

Suggestions and boosts, please, we need reach for this! 🤓​

#TwitterMigration #Science #Scientist @phdstudents @academicchatter @neuroscience @cognition

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Joram Mooiweer boosted
Sander W. van der Laan

Checking out this new place...

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Joram Mooiweer

@EricPelletier @ShaiCarmi Exactly!

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Joram Mooiweer boosted
Mike Schumacher PhD

A mini-gut intestinal #organoid imaged by #immunofluorescence confocal #microscopy ✨

#sciart #science

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Joram Mooiweer boosted
Shai Carmi

An important news piece in Science about reviewing preprints. IMO, this is the future - I feel that journals add very little value nowadays, if not doing straight out harm.
But... ->

science.org/content/article/re

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Joram Mooiweer

@ShaiCarmi I do like the idea of ‘preprint peer-review by the community’.
But what would the role of journals than be? To scan preprint servers and ‘publish’ pre-prints picked by journal editors? As a sort of quality label?

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Joram Mooiweer boosted
Soragni:Lab

I truly loved giving this interview, really excited to see it in print! Very nice piece by Michael Eisenstein, hope you enjoy it

#organoids #precisionmedicine

nature.com/articles/d41586-022

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