Joram Mooiweer @JoramMooiweer@qoto.org
Celiac disease | Mucosal immunology | iPSCs, Intestinal Organoids, T cells & organs-on-chips🔬
PhD-candidate Genetics dept. 🧬 University Medical Center Groningen,
the Netherlands
Joined Nov 2022
Joram Mooiweer
boosted
EU ready to back immediate #openaccess without author fees - Research Professional News
👉 "The #EU is ready to agree that immediate open access to papers reporting publicly funded #research should become the norm, without authors having to pay fees, and that the bloc should support non-profit scholarly #publishing models." 👍💪
Joram Mooiweer
boosted
You've probably already seen it but hey, perhaps a deeper dive is valuable. The entire editorial board (40+ academics) resigns from Elsevier's NeuroImaging and starts a new non-profit OA journal: Imaging Neuroscience.
'Flipping' a journal isn't that common but it sure has an impact.
Joram Mooiweer
boosted
(Thread)
1/ What is the physiological impact of dietary proteins on steady-state T cells? Nelson Vaz and Ana Faria, my undergrad mentors, wondered about this question for decades.
Joram Mooiweer
boosted
https://www.science.org/doi/10.1126/science.abp9563 “Engineered #StaphEpidermidis generated #tumor-specific #Tcells that infiltrated and reduced the growth of localized and metastatic #melanoma. In combination with immune checkpoint inhibitors, these engineered skin bacteria caused mice to reject established tumors. These findings suggest that immune responses from engineered commensals may have therapeutic potential against other tumor antigens of interest.”
Joram Mooiweer
boosted
Gut tregs:
"Thus, Helios+ effector tTregs proliferate via CD28 and require neither ICOS nor MHCII for maintenance. In contrast, RORγt+ pTregs utilize CD28 and ICOS."
cc @mucida
https://www.mucosalimmunology.org/article/S1933-0219(23)00017-X/fulltext
Meeting inspirational people makes so much difference!
Just got back home in the Netherlands. Had an amazing time at the combined Keystone Symposia on Molecular & Cellular Biology meeting #KSOrganoids23 #KSStemCell23 and visiting the Robert Barrett lab at Cedars Sinai Medical Center, LA.
It is incredible to have met and talked to so many fantastic scientists during this trip. The way this meeting and visit helped to get inspiration, make new connections and reinforce existing collaborations is incomparable. Heading back to the lab with renewed excitement!
Now back to work: I've got a thesis to finish.
Just 2 days until Keystone Symposia on Stem cell applications & Organoid disease models in Colorado.
Very, very excited to join this meeting. If you’re there, let’s meet!☕️
Looking forward to talk about the work of our team on patient-derived immunocompetent cultures, intestinal organoids and tissue-chips to model intestinal inflammation.
Joram Mooiweer
boosted
RT @Masopust_Vezys
Authored by Andrew G. Soerens et al, we show that #Tcells are capable of proliferating in response to iterative stimulation for over 10yrs! And produce enough progeny to occupy a volume 30,000x the Earth's volume! @Nature https://www.nature.com/articles/s41586-022-05626-9
@zpneal
Not exactly what you mean, but community peer-review was able to evaluate preprints equally to (High IF) scientific journals:
@drtifftaft Absolutely! 😊
Joram Mooiweer
boosted
RT @svpino@twitter.com
11 ways ChatGPT saves me hours of work every day, and why you'll never outcompete those who use AI effectively.
A list for those who write code:
1 of 16
@MarkHanson My reaction exactly!
Since the peer-review experiment failed, this sounds like the right alternative:
Pre-print peer review by the scientific community.
Love the idea and apparently works pretty well!
Joram Mooiweer
boosted
On #scienceTwitter, my favourite thing were reading and, on rare occasions, writing "paper/preprint threads". From the researchers I followed and through the #Twitter algorithm, this became my most important source for new #research.
While people start to do the same on #Mastodon, I have the feeling that I miss important work bc no algorithm "saves" it for me if I don't watch my timeline constantly.
Two simple solutions would be: a commonly accepted hashtag that everybody uses when writing "paper threads" or a [...] @ a.gup.pe group with a similar adaptation rate.
#Question 1: is there already a mechanism for this that I missed?
#Question 2: What hashtag or group name?
I saw #TootPrint before. Maybe #PaperInAToot? #PaperInAPost? #PaperInAThread? #PaperPost? #MastoPrint?
Suggestions and boosts, please, we need reach for this! 🤓
#TwitterMigration #Science #Scientist @phdstudents @academicchatter @neuroscience @cognition
Joram Mooiweer
boosted
Checking out this new place...
Joram Mooiweer
boosted
A mini-gut intestinal #organoid imaged by #immunofluorescence confocal #microscopy ✨
Joram Mooiweer
boosted
An important news piece in Science about reviewing preprints. IMO, this is the future - I feel that journals add very little value nowadays, if not doing straight out harm.
But... ->
@ShaiCarmi I do like the idea of ‘preprint peer-review by the community’.
But what would the role of journals than be? To scan preprint servers and ‘publish’ pre-prints picked by journal editors? As a sort of quality label?
Joram Mooiweer
boosted
I truly loved giving this interview, really excited to see it in print! Very nice piece by Michael Eisenstein, hope you enjoy it
Celiac disease | Mucosal immunology | iPSCs, Intestinal Organoids, T cells & organs-on-chips🔬
PhD-candidate Genetics dept. 🧬 University Medical Center Groningen,
the Netherlands
Joined Nov 2022
