Joram Mooiweer @JoramMooiweer@qoto.org

#introduction I’ve been reluctant to engage with yet another social media platform, but this seems as good as any to keep up with others’ #science, which I do enjoy!

I’m a #postdoc at Penn (Microbiology) working with @SunnyShinLab. My research interests include #immunometabolism, #InnateImmunity, and #HostDefense in the lung. I’m also passionate about #education, #mentorship, #MentalHealth, and #DEI in STEM.

When not in lab, I’m either running and/or listening to the latest hard rock album!

A key thing I've learned about Mastodon: When you find people you know and want to keep up with, don't just follow them — add them to a list!

Merely following is not enough, b/c their posts may not show up in your feed at a time you're logged on. Unlike FB or Twitter, Mastodon has no algorithm to resurface your friends' posts from hours or days ago.

So create a list called "Friends" and check it when you're on. This will ensure that you see what they posted while you were away.

#introduction

joining mastodon to discuss #science, #cardiology, #immunology, #immunocardiology, tissue repair, #aging, amongst other topics.

Welcome aboard!

@JeffMold

@ImmunoCardioLab

#Immunology

Tools for off- the-shelf CARTs:

"Conventional CRISPR-Cas nucleases install sequence-specific DNA double-strand breaks (DSBs), enabling gene knock-out (KO) or targeted transgene knock-in (KI). However, simultaneous DSBs provoke a high rate of genomic rearrangements which may impede the safety of the edited cells. Here, we combine a non-viral CRISPR-Cas9 nuclease-assisted KI and Cas9-derived base editing technology for DSB free KOs within a single intervention."

#CARTcells #Immunology #Immunotherapy #crispr #preprint

https://www.biorxiv.org/content/10.1101/2022.11.11.516008v1

POLL: If you've been on #Mastodon for over a week and used it each day, how likely are you to go back to using Twitter on a regular basis?

Boost for a larger sample size please.

Hello everyone - I am Hugo Mouquet - PhD, molecular #immunologist & head of the humoral immunology lab @ Institut Pasteur - Our lab investigates #antibodies and B-cell responses to viral pathogens in humans | #HIV, #hepatitis #viruses, #SARSCoV2, #chikungunya & more...

Now in #Science magazine (@sciencemagazine)

Katherine Freitas, Julia Belk, Ansu Satpathy, Crystal Mackall, & colleagues use #CRISPR screen to identify MED12 & CCNC as key regulators of human #TCell activation & function. Inactivation in #CART cells leads to increased T cell expansion, #metabolic fitness, & #tumor control!

bit.ly/Sci_abn5647

Be sure to also check out the accompanying Perspective by Caitlin Zebley & Ben Youngblood:

https://bit.ly/Sci_adf0546

#CancerImmunology #immunotherapy

#introduction I am an #immunologist at the #universityoftoronto. I study how our #mucosal immune system can influence our health, especially brain health. I love constructive discussions about science and how to make #academia a better place for everyone. I love #cooking, #gardening, #singing, #canoeing and learning from my 2 sons. Oh and my 3 @Cats too.