Peter Sarkies @PSarkies@qoto.org
Epigenetics and Evolution at Oxford Biochemistry. Wide range of science interests. Also passionate about heavy metal, literature and climate justice.
Joined Nov 2022
@LauraKT@mas.to Hunt's Cuts. Two typos waiting to happen??
Peter Sarkies
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Our latest editorial round-up of CUSP news and events has just gone live. → https://www.getrevue.co/profile/cusp_uk/issues/a-lasting-legacy-cusp-newsletter-nov-2022-1427527
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HT @ProfTimJackson cc #PostGrowth #degrowth #WellbeingEconomy #EcologicalEconmics #NewEconomis #RethinkingEconomics #postwachstum #decroissance #decrecimiento #postcroissance #ProsperityWithoutGrowth #LifeAfterCapitalism #GoodLife #SelfTranscendence
Reading #WillSelf new work #WhyRead. Scholarly essays, including superb essay on #Kafka putting him in context of the times in which he wrote. Self's immense vocabulary is a little challenging for someone like me who mostly reads and writes science... but despite this, still very engaging and readable
Peter Sarkies
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Hot off the press:
Politicians’ growth fetish is the problem—and Sunak is headed for the same budget trap as Truss | New @TheGuardian Op-ed by @ProfTimJackson.
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#AutumnBudget #RishiSunak #JeremyHunt #UKtreasury #PostGrowth #Degrowth #SecularStagnation #Recession #WellbeingEconomy #GrowthDependency #BeyondGDP #EconTwitter
Peter Sarkies
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Mainstream #politics has long proved resistant to the arguments of those who question the pursuit of unending #EconomicGrowth. How do you break through this powerful denialism? Here are some reflections on the potential of #GrowthDependency as a framing that can be (and has been) used to drive political interest in #PostGrowth and #Degrowth ideas by connecting them to immediate political priorities. → https://cusp.ac.uk/themes/aetw/blog-rd-postgrowth-mindset
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#WellbeingEconomy #PostWachstum #PostCroissance #Postcrecimiento
Peter Sarkies
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RT @MoltagDK@twitter.com
Margot Ernst group at @MedUni@twitter.com newest review discusses the function of #cannabinoids on cys-loop #receptors, including their clinical use for the treatment of #epilepsy, #ChronicPain and other #neuropsychiatric conditions. Congratulations to the group! https://tinyurl.com/j5b7j9tw
Crisis in HE
@gulbruth I completely agree that strikes are rarely a good solution for those in HE. They cause us excess stress, which is different for most workers (you physically can't run more train services to make up for the ones that are lost, whereas we end up cramming more teaching and research work into the weekends).
Peter Sarkies
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Birdsite
I see a lot of pundit speculation and debate that goes something like, “well, only the hackers and cybersecurity people are moving to Mastodon - and everyone else is just going to stay on #Twitter “, but the thing the folks saying this do not understand is that we are a canary.
We watched Twitter get rid of qualified #cybersecurity people who we personally knew. We understand the implications of privacy teams and lawyers being fired has on our data. We hollered about the way the new blue check system would be abused days before billions were lost by a couple companies. We understood the implications of rapid and haphazard terminations. The bottom line is:
1) We know our login data, DMs, and private posts really aren’t secure at all anymore due to lost competent staff and disgruntled employees,
and
2) Twitter probably won’t just shut down this month or next month, but it’s going to start having some serious and unpredictable financial and technical problems due to the people who were let go as well as Elon’s apparent instability and lack of checks.
So, we migrated. Other communities don’t necessarily have this inside baseball, and they understandably just feel like Twitter is too big to fail. We will see if stuff that happens over the coming weeks pushes more folks here, or to other social media sites. Depends a lot on our outreach and what we do with this community.
Peter Sarkies
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Affordable housing for all doesn’t have to cost the #earth. #England’s current #housing strategy will consume the UK's entire #CarbonBudget by 2050. There are alternatives, but they face political and economic barriers.—Recent blog by Sophus zu Ermgassen et al summarising their in-depth research on housing policies in the context of #ClimateChange. → https://cusp.ac.uk/themes/aetw/blog-sze-housing-within-planetary-boundaries/
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#PlanetaryBoundaries #PostGrowth #degrowth #WellbeingEconomy #ProsperityWithoutGrowth #DoughnutEconomics #SocialPolicy
@killyourfm Nice! enjoyed the Soundgarden nod in the lyrics too...
@killyourfm Do you have a cat named Pantera?
Peter Sarkies
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Hello! By way of introduction, here are some of our recent papers / preprints!
1) A preprint on high-res promoter interaction analysis in a rare cell type (type 3 Innate lymphoid cells) and using these data for linking Crohn's GWAS variants with target genes:
https://www.biorxiv.org/content/10.1101/2022.10.19.512842v3
2) A protocol article on Capture Hi-C analysis using the tools we (and others) developed:
https://www.nature.com/articles/s41596-021-00567-5
3) A review about enhancers and enhancer-promoter communication:
https://link.springer.com/article/10.1007/s00018-021-03903-w
@epigenetics Hello! my lab is trying to find out why #epigenetic mechanisms evolve so rapidly in eukaryotes (and in #cancercell #evolution too). Everywhere we look there is diversity under the surface. Always looking for collaborations to investigate in far-flung corners of the tree of life!
Peter Sarkies
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#climatecrisis
I have discovered #BurnWild on the #bbc. Presented by Leah Sottile it is an incredible podcast charting the history of how big business attempted to shut down environmental protests by getting protesters labelled as terrorists. They succeeded in the US through "terrorism enhancement" legislation. I'm worried that some of the new protest laws being formulated in the UK may have similar consequences. I don't think there could ever be such a thing as an "eco-terrorist" let alone now. https://www.bbc.co.uk/sounds/brand/p0cx6tw7
@EJBrand
Here's 7 of my favourites
#chinuoAchebe
#irismurdoch
#kafka
#georgeorwell
#albertcamus
#ursulakleguin
#isaacasimov
#music
Challenged by my partner to come up with 5 candidates for best #rock song ever I proposed (not in order)
#nirvana aneurysm (from massively underrated album #incesticide)
#ratm bulls on parade
#TheClash London Calling
#Deftones Passenger
#Tool Lateralus
Slightly eccentric choices I concede. And no doubt if you asked me another day it would be totally different...
Literature. Peripheral mention of Genocide. Longish!
I just finished reading WG #Sebald Vertigo. Sebald was a professor of German literature at the University of East Anglia. He's more famous for writing about the aftermath of the Holocaust (e.g. Emigrants) but Vertigo is his first book and introduced his strange style to the world. Fittingly given the title, I found it a disconcerting read. Ostensibly a travelogue, complete with blurred pictures, some purportedly from a personal camera, it follows the author's trip from the UK to his childhood village (which, bizarrely, is referred to as "W." like in some kind of 19thC novel) in alpine Bavaria, via Venice, Riva and some nauseating bus journeys. But weirdly there are references to fictional characters (the Hunter Gracchus, who was a character in a bizarre Kafka short story- neither dead nor alive) and real, dead characters (the writer Stendahl and his lovers- presumably a fictionalised account). Some of the prose is mesmerizing - and almost effortlessly so as it describes the beautiful countryside, or the nervousness the traveler feels when he thinks he is being followed, which I found quite relatable. What makes the book disconcerting is that you don't know what is real, what is "really imagined" (ie when Sebald thinks he is being followed) and what is purely fictional. A good example is the description of the death of a real hunter in W., which happened during Sebald's childhood (perhaps? we don't know)- which parallels Gracchus' fictional death. In this context the pictures cease to be innocent travel snaps but instead take on a more sinister function as part of the deception wrought on the reader. I'm not sure what to make of it. would be interested in the opinions of anyone else who has read it.
Peter Sarkies
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Folks interested in #CancerDrugDevelopment should check this months edition of #MolecularOncology 👇
https://febs.onlinelibrary.wiley.com/toc/18780261/2022/16/21
A thematic issue with excellent reviews on #DrugResistance #DrugDevelopment and #DrugDesign
We also contributed a review on targeting dNTP #metabolism in cancer, which we discuss in the context of (selectively) inducing DNA lesions in cancer cells and in the refinement of current antimetabolite based therapies
Peter Sarkies
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The life scientific is one of the most interesting scientific podcasts out there, featuring the life and discoveries of lots of interesting scientists.
The last episode is about Bambos Kyriacou, from the University of Leicester. For those who do not know him, Bambos is an excellent Drosophilist who has made unique contributions to the field of circadian rhythm. He is also super fun.
Do my listen to this if you haven't yet and pass it on to your students.
https://www.bbc.co.uk/sounds/play/m001d5cq?partner=uk.co.bbc&origin=share-mobile
Epigenetics and Evolution at Oxford Biochemistry. Wide range of science interests. Also passionate about heavy metal, literature and climate justice.
Joined Nov 2022
