@arteteco if you feel a regular mouse is uncomfortable on your wrist then a vertical mouse will be more comfortable. However if an ordanary mouse is already comfortable for you i dont think youll notice a huge difference in comfort. For me neither are uncomfortable but a vertical mouse is more natural feeling for sure.
The downside is you cant switch hands on a vertical mouse. Otherwise I find it marginally superior. Its also bigger so less suited as a portable mouse.
@arteteco It will certainly alleviate that for you. I try to minimize my need on the mouse all together so i get less strain in general. I use tiling window managers and spacemac to keep me confined to the keyboard side as much as possible