@freemo well if it's actually more comfortable, and if you like it basically. Just broke my mouse wheel beyong repair, so I'm shopping for a new one
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@arteteco if you feel a regular mouse is uncomfortable on your wrist then a vertical mouse will be more comfortable. However if an ordanary mouse is already comfortable for you i dont think youll notice a huge difference in comfort. For me neither are uncomfortable but a vertical mouse is more natural feeling for sure.
The downside is you cant switch hands on a vertical mouse. Otherwise I find it marginally superior. Its also bigger so less suited as a portable mouse.
@freemo thanks, yeah I'm feeling a bit of stress on the wrist lately, I can try it out and see how it goes
@arteteco It will certainly alleviate that for you. I try to minimize my need on the mouse all together so i get less strain in general. I use tiling window managers and spacemac to keep me confined to the keyboard side as much as possible
Twelve years ago, I started getting severe pain in my right-hand wrist. In short, cupital tunnel syndrome. I bought a vertical mouse and have never looked back. Then, such mice were relatively expensive. This hasn't been the case for several years. However, you may have to pay a premium for a left-hand versions as there's less choice in the market.
@arteteco I like them, at least more than regular mice. I prefer the Steam Controller, but that seems to have been discontinued. I think I'll try a trackball next.
@arteteco
You should definitely try various models physically, as the ergonomics may vary quite a bit.
I'd say I've got average-sized hands for a male grownup. And while I'm quite happy with my Anker mice, my wife doesn't like them at all, because the buttons are too big for her and she can't rest her hand on the mouse.
She likes her SilverCrest vertical mouse better - which is in turn suiting her smaller fingers much better...
Just my 2 ct 
@snow I'm seeing so many different opinions that now I feel like I HAVE TO try it for myself!
I bought one because I was having severe problems with epicondylitis
I think it's great, it just saved my life
I can't wait to move to a whole ergonomic keyboard too
@AbbieNormal I moved to a vertical mouse too, I had to try a bunch though before finding a good one.
I also have epicondylitis and I bought an ergonomic keyboard... I was overly slow with it though, didn't like it.
Let me know if you find something nice
@arteteco Me I have one and use it exclusively on my desktop.. what do you need to know?