"During systemic Salmonella Typhimurium (STm) infection germinal centers are absent, whereas extensive extrafollicular switched antibody responses are maintained. The mechanisms that underpin the absence of GC formation are incompletely understood. Here, we show that STm-induces a reversible disruption of niches within the splenic microenvironment, including the T and B cell compartments and the marginal zone."
#GerminalCenter #Salmonella #Immunology #Infection #HostPathogen #Preprint
NB I hadn't realised that @biorxivpreprint also incorporated the possibility of adding a graphical abstract to the preprint page, kudos to @richardsever et al
@ImmunologyKing They're already using the aroA mutant which is quite attenuated. @zivshulman described something similar with LPS injection I believe? We've not stained for FDCs in gut I'm afraid!
question from a non-Salmonella #Immunologist - this paper focuses on systemic Salmonella; are similarly disturbed #immune / #stromal events occurring in gut/mesenteric LN) after oral Salmonella or does it vary according to virulence? @mucosal_immunology_ethz