"Our findings underscore the importance of cell death in defense against intracellular bacterial pathogens and provide an example of how layered and hierarchical immune pathways can provide robust defense against pathogens that have evolved a broad arsenal of virulence factors."
#Shigella #HostPathogen #CellDeath #Apoptosis #InnateImmunity #Pathogen #Microbiology #Immunology
@cyrilpedia And the flip side to this shows how many layers of host defences need to be overcome by pathogens that succeed in surviving in the intracellular environment. Looking at you.... #TB #tuberculosis! 😉
@gpollara An interesting aspect of this was discussed by the senior author of this @eLife paper, Russell Vance, who co-authored a perspective piece in @ImmunityCP in 2014 about "The Macrophage Paradox", essentially why do so many pathogens find it so cozy inside the cell type that's supposed to eat them.
@hasmis @gpollara @eLife @ImmunityCP
In a most delightful way
@cyrilpedia @gpollara @eLife @ImmunityCP A spoonful of cyanide makes the bacteria go down....