'The results provide evidence that elevated IFNα levels act directly on B cells to facilitate autoantibody production and further highlight the importance of IFN signaling as a potential therapeutic target in SLE.'
#immunology #interferon #Lupus #SLE #AutoAntibodies #Autoimmunity
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Fits well with earlier work from Jocelyne's lab:
"Type I IFN sets the stringency of B cell repertoire selection in the bone marrow" (1999)
https://academic.oup.com/intimm/article/11/2/279/759572
and
"Type I Interferon controls the onset and severity of autoimmune manifestations in lpr mice" (2003)
https://www.sciencedirect.com/science/article/abs/pii/S0896841102001099
