Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
"The exhibition is, in essence, an installation of museum-approved counterfeits, products of research for springboarding imagination about what the ancient world may have looked like. But most of the reconstructions feel brand-new—unweathered and therefore unreal. They serve as components of an art-historical argument, rather than as art per se."
https://newcriterion.com/blogs/dispatch/chroma?ref=The+Browser-newsletter
This one is for everyone nostalgic for old school metabolic maps
"We studied the genetic architecture of the human plasma metabolome using 913 metabolites assayed in 19,994 individuals and identified 2,599 variant–metabolite associations (P < 1.25 × 10−11) within 330 genomic regions, with rare variants (minor allele frequency ≤ 1%) explaining 9.4% of associations."
"From their hero Paul Cézanne, they’d learned to break down and reassemble multiple perspectives. Scrutinizing central African sculpture in Paris’s colonial ethnology museum, they’d learned to clarify bodies into pure geometry. Crossing those two wires they jolt the history of western art, and spark a whole new kind of image that, for the first time in 500 years, is done with simulating real life. "
Serious heart damage is the most severe side effect of doxorubicin in cancer chemo, but the cause is not clear.
New work from Abe et al shows that
"DOX accumulated in mitochondria by intercalating into mitochondrial DNA (mtDNA), inducing ferroptosis in an mtDNA content-dependent manner. In addition, DOX disrupted heme synthesis by decreasing the abundance of 5'-aminolevulinate synthase 1 (Alas1), the rate-limiting enzyme in this process, thereby impairing iron utilization, resulting in iron overload and ferroptosis in mitochondria in cultured cardiomyocytes."
How Candida poaches host heme:
"While vacuolar function and the endocytic pathway were found to be essential for heme-iron utilization (Weissman et al., 2008), the mechanism for heme internalization into the cell was unknown. Here, we fill this gap, and identify a family of membrane proteins, previously classified as FREs based on sequence homology (Almeida et al., 2009; Baek et al., 2008), that are essential for heme uptake into the cell."
It's like the Royal Navy weaponised carne de porco à alentejana.
(from Stanley Tucci's wonderful memoir, Taste).
"Kitefin sharks (Dalatias licha) have been known about since the 18th century, but it was only in January 2020 that scientists saw them glowing in the dark for the first time. They are not the only bioluminescent sharks – roughly one in 10 species has that ability – but at up to 1.8 metres, kitefins are by far the biggest that have been found."
You bet
"It’s now been 16 years since the publication of The Road, which makes the arrival of not one but two new McCarthy novels — rumours of which have abounded at least since he sold his archive to the Texas State University-San Marcos in 2009 — a major literary event."
https://www.ft.com/content/f3edb5d8-968e-4d0d-8bcf-ca920e1ea5df
"Won et al. demonstrate that PD1
inhibitor treatment alone induces
myocarditis in A/J mice, creating a mouse model for immune-checkpoint-inhibitor-associated myocarditis."
"Many of the earliest lanterns were made in Germany in the workshops of the Nuremberg toy makers. Early allusions to projection devices can be found in Giovanni Fontana (c.1420) and Giovanni della Porta (1589), but the first printed description appears in the second edition of Ars magna lucis et umbrae by Athanasius Kircher, published in 1671. "
https://www.lrb.co.uk/the-paper/v44/n21/chloe-aridjis/at-the-swedenborg
Word of the day:
"Kleptoplasty, the process by which a host organism sequesters and retains algal chloroplasts, is relatively common in protists"
#chloroplast
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001857
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
