Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
'En el extremo oeste del continente europeo, en una cueva de la costa atlántica, cuando el océano estaba a dos kilómetros por debajo de su límite marítimo actual, una pareja pescadora de neandertales recorrió esa distancia para hacerse con un preciado botín: marisco.'
'In summary, we demonstrate that human T cells possess a functional cGAS-STING signaling pathway that can contribute to antiviral immunity. However, regardless of its potential antiviral role, the activation of the cGAS-STING pathway negatively affects T cell function at multiple levels'
Kuhl et al @emboreports
'In this Review, we give an overview of the regulation and cancer relevance of major metabolic pathways in which acetyl-CoA participates. We further discuss recent advances in understanding acetyl-CoA metabolism in normal tissues and tumours and the potential for targeting these pathways therapeutically.'
Great lamb & yoghurt recipe from Ottolenghi's "Simple". Bonus: it actually is simple - unlike most of his recipes, it does not require that you live next to a souk dreamed up by Italo Calvino for one of his invisible cities.
Colograph of book cover by Madalena
"The works presented here are created with alternative materials rather than etched on copper. From squashed paper costumes to packaging and leather book covers, objects are inked with different processes, both intaglio and planographic."
'Through riveting and braided profiles of Lee Krasner, Elaine de Kooning, Grace Hartigan, Joan Mitchell, and Helen Frankenthaler, Gabriel illustrates in this groundbreaking group biography how New York City supplanted Paris as the modern art capital of the world in the 1940s and ’50s.'
https://www.theatlantic.com/books/archive/2023/02/art-writing-books-recommendation-list/672947/
Young Napoleon presents project to thesis committee
Villa Masséna Musée, Nice
Review at EJI
"Dysregulation or overproduction of IL-6 leads to autoimmune diseases such as multiple sclerosis (MS) and rheumatoid arthritis (RA), in which Th17 cells are considered to be the primary cause of pathology. Given the critical role of IL-6 in altering the balance between Treg and Th17 cells, controlling IL-6 activities is potentially an effective approach in the treatment of various autoimmune and inflammatory diseases."
#Immunology #Treg #Th17 #Autoimmunity
https://onlinelibrary.wiley.com/doi/full/10.1002/eji.201040391
Cover image by Madalena Parreira for JEM in 2016, based on a paper by Kuchmiy et al, "NLRP2 controls age-associated maternal fertility"
Weekend in Nice learning about ageing, #telomeres & #zebrafish with @miguelgf
"Here, we have developed a robust computational framework to determine the prognostic strengths of a variety of molecular features relative to conventionally utilized clinical factors such as tumor stage, age, and histopathology across a vast compendia of cancer cohorts from TCGA."
https://www.cell.com/cell-genomics/fulltext/S2666-979X(23)00018-6
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
