Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
My latest Clinical Pipeline column for #NatureMedicine is out today, a look at Moderna's RNA vaccine for RSV & a survey of what's, well, in the pipeline, for RSV immunotherapies, including vaccines and monoclonals.
#Vaccine #drugdiscovery #drugdevelopment #mRNA #RSV #immunology #MonoclonalAntibody
"Here, we have identified a population of innate lymphocytes that we term tissue-resident memory-like natural killer (NKRM) cells. In response to murine cytomegalovirus infection, we show that circulating NK cells were recruited in a CX3CR1-dependent manner to the salivary glands where they formed NKRM cells, a long-lived, tissue-resident population that prevented autoimmunity via TRAIL-dependent elimination of CD4+ T cells."
Schuster et al @ImmunityCP
#Immunology #NKCells #ImmuneRegulation
https://www.cell.com/immunity/fulltext/S1074-7613(23)00026-2
What a heartbreaking novel. I saw Kasdan's film version in the 80s, a very good movie with one of the all time best siblings castings (William Hurt, Kathleen Turner, Ed Begley Jr & David Ogden Stiers).
But Tyler's book is even better.
'Saura reunió una obra fotográfica con miles de negativos que quizás sea ahora buena ocasión para mostrar una completa relectura. Autodidacto, con solo 19 años expuso las fotos tomadas con una Rolleiflex en la Real Sociedad Fotográfica de Madrid.'
https://elpais.com/cultura/2023-02-14/la-piel-de-fotografo-de-carlos-saura.html
Sagy et al. have recently published in #NatureMedicine an analysis of the real-world efficacy of #JYNNEOS, the #smallpox shot redeployed against #monkeypox.
https://www.nature.com/articles/s41591-023-02229-3
Last Fall I wrote a column for Nature Medicine that touched on the FDA's Animal Rule, used in the approval of anti-smallpox drugs due to the difficulty in designing ethically acceptable efficacy screens.
'Back in Aix, his discussion circle had included not only Émile Zola, on a fast track to celebrity, but a formidable young scientist called Antoine-Fortuné Marion. It was Marion who alerted the group to the recent revolutions in thought advanced by Lyell and Darwin. Zola articulated their response in 1865: ‘I see in the study of geology a new faith, a faith both philosophical and religious.’'
https://www.lrb.co.uk/the-paper/v45/n04/julian-bell/mass-equals-pigment
Portrait with poncho & bees.
(Photo by Karen Liu, who's on Mastodon somewhere)
I hope they made it into the acknowledgments
'Over the years, the film has acquired a kind of notoriety, too, because Beals did so little of Alex’s dancing. Most was performed by a French dancer, Marine Jahan. And in the climactic audition scene, there were more doubles: the gymnast Sharon Shapiro for the dive into the roll; and for the backspin, the 16-year-old B-boy Richard Colon, better known as Crazy Legs.'
https://www.nytimes.com/2023/02/09/arts/dance/flashdance-40th-anniversary.html
'P. ¿Qué es Cities of Asylum?
R. Una organización destinada a ofrecer refugio y protección a escritores de todo el mundo que lo necesitan. Hoy responde a las siglas de ICORN (International Cities of Refuge Network). La sede central está en Noruega. Me siento orgulloso de haber sido uno de los promotores.'
The picture is from William Vollmann's "Europe Central" - but the quote also sums up an extraordinary book, Julian Barnes' novel about Shostakovich, "The Noise of Time".
"Accurate prediction of TCR–antigen specificity can be described as deriving computational solutions to two related problems: first, given a TCR of unknown antigen specificity, which antigen–MHC complexes is it most likely to bind; and second, given an antigen–MHC complex, which are the most likely cognate TCRs?"
"Scientists and artists are both motivated by creativity and curiosity, and science and art can be mutually reinforcing, supporting discovery and innovation. This Community Page highlights resources for individuals, groups, and institutions to advance science–art collaborations."
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001992
"Vaccines that resulted in speedy delivery of antigens to follicles preserved intact antigen and generated better antibody responses. These findings may have implications for the design of vaccines against difficult to neutralize or genetically variable pathogens"
#Immunology #ImmunologicalMemory #Antibody #GerminalCenter #Bcells #Vaccine
The FT is featuring phage therapy in the context of the antibiotic resistance crisis.
https://www.ft.com/content/c6df6bc4-f87e-4adb-bc92-97985f031550
ICYMI, we did an episode of the #EMBOPodcast featuring pediatric infectious disease physician Ameneh Khatami who published a single patient study in @EmboMolMed
It's the story of a seven-year-old girl infected with a multi-drug resistant #Pseudomonas strain who underwent #PhageTherapy.
https://www.embo.org/podcasts/the-enemy-of-my-enemy/
#antibioticresistance
#PersonalizedMedicine #Phage #Microbiology
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
