Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
A mysterious 1st century Roman tower just outside the town of Belmonte (Portugal) - no knows what it was: home, military watchtower, administrative building, trading center or something else entirely.
"Thus, studies of MSMD (Mendelian susceptibility to mycobacterial disease ) have revealed that human antimycobacterial immunity is a genetically controlled quantitative trait: the lower the level of IFN-γ activity, the more severe the disease and the higher its penetrance"
#immunology #InfetionImmunity #InfectiousDisease #mycobacterium #tuberculosis
Saint in Pamplona realizes what happened to Jake Barnes in "The Sun Also Rises"
Hallmarks of neurodegenerative disease
"In this review, we argue that a set of hallmarks define NDDs, namely: pathological protein aggregation, synaptic and neuronal network dysfunction, aberrant proteostasis, cytoskeletal abnormalities, altered energy metabolism, DNA and RNA defects, inflammation, and neuronal cell death"
'Studying the art of people with a range of brain injuries can lend insights into “the different ways the brain engages in creative activity,” King says. Use of color, realism versus abstraction, and changes in other formal elements over time can hint at the deterioration of specific brain structures, she says.'
'Marty once said of Dave, “I was lucky to get him. We taught him how to grow Tetrahymena, and he taught us a lot about how to do science.”'
Print by Madalena Parreira & Constança Arouca
“Map 10 The Turbulence Chart (Lviv, Ukraine, circa 1890)
This engraving was part of a set that illustrated the fabled, never published, “Order & Disorder” manuscript by Bronislaw Zamoyski (sometimes referred to as the “Leibniz of Lviv”). The text and all accompanying illustrations were thought to have been lost when the Russian Army captured Lviv in 1914. How it was obtained by von Willebrand remains unknown.”
'In the following review, we perform a synthesis of the different types of tumor antigens now being targeted with TCR-T cell therapy in the clinic and new promising antigens developed at the preclinical stage.'
https://www.science.org/doi/10.1126/sciadv.adf3700#.Y-1cGIGJPoE.linkedin
My latest Clinical Pipeline column for #NatureMedicine is out, a look at Moderna's RNA vaccine for RSV & a survey of what's, well, in the pipeline, for RSV immunotherapies, including vaccines and monoclonals.
#Vaccine #drugdiscovery #drugdevelopment #mRNA #RSV #immunology #MonoclonalAntibody
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
