Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
'We show here that lipid-mediated engagement of invariant natural killer T (iNKT) cells with enterochromaffin (EC) cells, a subset of intestinal epithelial cells, promoted peripheral serotonin (5-HT) release via a CD1d-dependent manner, regulating gut motility and hemostasis.'
#Immunology #MucosalImmunology #Neuroimmunology
https://www.cell.com/immunity/fulltext/S1074-7613(23)00236-4
'Provision of Signal 2 from DCs to naïve T cells during priming is the second critical step [30], which usually takes the form of DC-expressed CD80 and CD86 interacting with CD28 on T cells. Consistent with this, Cd80−/−Cd86−/− mice have impaired CD8+ T cell responses after Ad5 immunization, but for reasons that remain to be elucidated Cd28−/− mice have a different phenotype: delayed but not fully impaired CD8+ T cell responses'
#Immunology #Vaccine
Last Thursday, the FDA voted to approve Sarepta's microdystrophin gene therapy for #Duchenne muscular #dystrophy.
https://www.fda.gov/news-events/press-announcements/fda-approves-first-gene-therapy-treatment-certain-patients-duchenne-muscular-dystrophy
This was not an easy call, made on the basis of a biomarker rather than efficacy data. I wrote about it last month for Nature Medicine.
If a slipper falls on a rooftop visible from an exhibition, is it art? #discussamongstyourselves
A great week at the soon to be extinct Gulbenkian Science Institute/IGC teaching MD PhD students of the EMERALD program.
Targeting FGF21 and GLP-1 pathways in NASH. My latest Clinical Pipeline column for Nature Medicine is online.
#drugdiscovery #drugdevelopment #metabolism #LiverDisease #FattyLiver #SciComm
George and the FT might be hearing from The Onion's legal team soon.
https://www.ft.com/content/05808970-09a0-4f86-af23-4f05db627742
Targeting FGF21 & GLP-1 pathways in NASH. My latest Clinical Pipeline column for Nature Medicine is online.
#drugdiscovery #drugdevelopment #metabolism #LiverDisease #fattyliver
There's more to gasdermin than just proptosis.
'Our study supports that differential cleavage of GSDMD can be understood as a regulatory hub controlling immunity versus tolerance in the small intestine.'
#Immunology #mucosalimmunology
"For at least two centuries, scientists have been enthralled by the “zombie” behaviors induced by mind-controlling parasites. Despite this interest, the mechanistic bases of these uncanny processes have remained mostly a mystery."
'The analyses of RANK and RANKL expression in large cohorts of breast cancer samples and functional studies in RANK+ breast cancer patient-derived xenografts (PDXs) revealed a key role for RANK in postmenopausal women with estrogen receptor negative (ER-) breast cancer.'
Ciscar et al @EmboMolMed
https://www.embopress.org/doi/full/10.15252/emmm.202216715
Primer on the clinical uses of base editing tech @PLOSBiology
"In this Essay, we highlight base editing technologies and their development from bench to bedside. Base editing, first reported in 2016, is capable of installing C•G to T•A and A•T to G•C point mutations, while largely circumventing some of the pitfalls of traditional CRISPR/Cas9 gene editing."
#MolecularBiology #GeneTherapy
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002071
The von Willebrand Trust strikes again.
At the opening of "Oubliette" in Biblioteca Camões. Largo Calhariz 17 1º andar 1200-086 Lisboa. 16.06.2023 Até 30.06.2023. Exposição Coletiva.
Portrait of the artist making last minute adjustments. Congratulations to @madparreira @anaanajottajotta @jorgenesbitt @consta_arouca on a very successful opening. If you couldn't make it last night, 'Oubliette' will be at Biblioteca Camoes in Lisbon until June 30th.
#Art #artmastodon #artgallery
Back in (very sunny) Heidelberg! Looking forward to meeting students & postdocs at the Uni and reconnecting with my former colleagues at EMBO.
Who says we don't need another heron? by @hunchbacksociety #ceramics #stoneware #art #artgallery #handmade #artmastodon
It's official - we have a business! More news soon.
Celebrating with David del Álamo in Madrid.
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
