Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
A spread from Some Disordered Interior Geometries (1980) © Woodman Family Foundation/DACS, London; MACK
https://www.ft.com/content/12c36952-240f-4898-94bf-e03df83e5883
'In an uncanny anticipation of his subsequent reception history, Johannes Vermeer made one of his first appearances in the printed record in the guise of a phoenix, the mythical bird that regenerates itself from its own ashes.'
https://www.nybooks.com/articles/2023/07/20/life-made-light-johannes-vermeer/
Looks like a Barbeito, #WinesOfMastodon
'But the 25-year bet, at least, has been resolved: No one has found a clear neural correlate of consciousness. Dr. Koch ended the evening by carrying to the stage a wooden box full of wine. He pulled out a 1978 bottle of Madeira and gave it to Dr Chalmers.'
For Throwback Thursday, an episode of the @EMBO Podcast on the clinical use of #phage to treat antibiotic resistant bacterial infection - with a brief stop at the Siege of Leningrad.
Featuring pediatric infectious disease physician Ameneh Khatami, historian Dmitriy Myelnikov, and Jessica Sacher of Phage Directory.
#EMBOPodcast #SciComm #PhageTherapy #Phage #antibioticresistance #sciencepodcast
Oubliette Exhibition at Biblioteca Camoes, Lisbon (Largo do Calhariz, 17). Show runs until the end of June (AKA Tomorrow!).
"The Pignerol Gates. (Rome, circa 1760).
Oubliettes have only one entrance – frequently a trap door on the roof, as was by all contemporary accounts the case of the Pignerol cell. They were constructed so that men could be literally thrown away and forgotten. In Pignerol we know for certain that the gate opened once in 1631 and then again in 1670. The plates you see here were etched in 18th century Rome, by an unknown hand, working from the sketches produced by the guards (the documents were then in the Vatican’s possession, they were transferred to Napoleon by Pius VII and are now in the Archives Nationales)."
Prof. Horst Manfrenjensenden, Ph.D.
Head of Collections, von Willebrand Trust.
#Art #Print #Printmaking #Etching #Handmade #Cartography#ArtGallery #Oubliette #artstagram
@anaanajottajotta @consta_arouca @madparreira@jorgenesbitt
'Zhang et al. provide crucial insights into the mechanisms driving the transition from the onset of autoimmunity to joint destruction in rheumatoid arthritis. The findings emphasize the central role of myeloid monocytes that overexpress both RANK and TLR2, and the sialylation of TLR2 in driving the fusion of monocytes and consequent resorption of bone.'
"The Outer Hebrides Palimpsest. (Edinburgh, Scotland, 1677).
Following the establishment of the Man in the Iron Mask’s identity by use of the correspondence and shopping lists of his jailor, Saint Mars, the Margrave embarked on a reanalysis of one his cartographic collection’s most celebrated collection items, the Outer Hebrides Palimpsest. The connection was tenuous at best: a group of Waldensians fleeing the brutal suppression of the sect in Piedmont arrived at the remote islands at around the time the map was produced. In keeping with our founder’s original mission, the process arrived at no useful conclusions – one unfortunate effect is the damage you see here, the Margrave's effort at redacting the map."
Prof. Horst Manfrenjensenden, Ph.D.
Head of Collections, von Willebrand Trust. Dresden, December 12th, 2022.
#Art #Print #Printmaking #Etching #Handmade #Cartography #ArtGallery #Oubliette
@anaanajottajotta @consta_arouca@madparreira @jorgenesbitt
Oubliette" Exhibition at Biblioteca Camoes, Lisbon (Largo do Calhariz, 17). Show runs until the end of June.
When life gives you lemons, make some of the funniest material ever caught on film.
"Harold (Ramis) embraced the cheapness of SCTV. Eugene (Levy), Catherine (O'Hara) and I were always moaning about how bad the sets looked and how shitty the props were. Harold would just chuckle and go, “That’s part of the charm!”"
"Here, we performed an extensive profiling of systemic myeloid cell populations and plasma soluble factors in NSCLC patients undergoing PD-L1/PD-1 blockade therapies, before and during treatment. Responder patients showed an elevated diversity of myeloid cell types, enriched in activated monocytic cells, and decreased granulocytic populations. Plasma FKN concentration correlated with myeloid cell diversity and response to PD-L1/PD-1 blockade."
Bocanegra et al @emboreports
#Immunology #immunotherapy
I love Current Biology - probably my favorite journal ever since I haunted the university library waiting for each new issue to read Sidney Brenner's Loose Ends. But maybe "Free Vaginas" is not the best layout option for their webpage.
Last two days to check out "Oubliette", a collective show by
@anaanajottajotta @consta_arouca @jorgenesbitt @madparreira at Biblioteca Camoes, Lisbon.
#Art #exhibition #artgallery
#sculpture #printmaking and more.
'Era una mujer sin nombre, de pie sobre una barricada en la Barcelona de 1936, una bandera rojinegra detrás. La imagen se imprimió en carteles y libros, se pintaron murales, y ella se convirtió en un icono de la Guerra Civil. Se desconocía su identidad. Y la del fotógrafo.'
They were here indeed .
A great week teaching MD PhD students of the multi-institutional EMERALD MD PhD program for the second year, this time at the Instituto Gulbenkian de Ciencia in Lisbon (last year at Centre for Genomic Regulation (CRG) Barcelona). Thanks to David Brena, PhD, Damjana Kastelic, Luis Moita, Gabriel G. Martins, Tiago Paixao & Ricardo Leite for making it all happen.
The first part was a one day workshop on modern scientific publication that David del Álamo and I designed. The rest was discussing the interplay of basic science and medical progress with a wonderful group of students.
... then it was the MHC, and then they came for CD38. Neuroscientists are pillaging the immune system for molecules again :)
Astrocyte CD38, neuronal circuit formation & social behavior in adults. Hattori et al @embojournal
Last few days to check out "Oubliette", a collective show by
@anaanajottajotta @consta_arouca @jorgenesbitt @madparreira at Biblioteca Camoes, Lisbon.
#Art #exhibition #artgallery
#sculpture #printmaking and more.
https://informacoeseservicos.lisboa.pt/contactos/diretorio-da-cidade/biblioteca-camoes
The current structure of science funding would make Max Perutz's work impossible and Perutz unemployed:
"Max, inspired by Bernal's vision that the structure of large and complex molecules such as proteins could be solved using X-ray diffraction, embarked on scaling a mountain in biology—solving the structure of haemoglobin. This was to take him more than 20 years."
https://www.embopress.org/doi/full/10.1093/embo-reports/kvf103
Keep your tacky Salazarist discovery monument - this is the Portuguese institution that matters.
'We show here that lipid-mediated engagement of invariant natural killer T (iNKT) cells with enterochromaffin (EC) cells, a subset of intestinal epithelial cells, promoted peripheral serotonin (5-HT) release via a CD1d-dependent manner, regulating gut motility and hemostasis.'
#Immunology #MucosalImmunology #Neuroimmunology
https://www.cell.com/immunity/fulltext/S1074-7613(23)00236-4
'Provision of Signal 2 from DCs to naïve T cells during priming is the second critical step [30], which usually takes the form of DC-expressed CD80 and CD86 interacting with CD28 on T cells. Consistent with this, Cd80−/−Cd86−/− mice have impaired CD8+ T cell responses after Ad5 immunization, but for reasons that remain to be elucidated Cd28−/− mice have a different phenotype: delayed but not fully impaired CD8+ T cell responses'
#Immunology #Vaccine
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
