Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
"This review discusses state-of-the-art techniques for the simultaneous profiling of multiple chromatin features in low-input samples and single cells, focusing on histone PTMs, DNA-binding, and chromatin proteins."
https://www.embopress.org/doi/full/10.1038/s44319-024-00199-2
'LINE1 (L1) retrotransposons have gained notoriety for their involvement in a slew of pathologies. While improper de-repression of L1 transcription may drive disease, mammalian cells have coopted L1 activation into mechanisms essential for cell function. New findings published by Mangiavacci et al (2024) in The EMBO Journal reveal the role of L1 RNA in stimulating osteogenic activity during bone repair in both mice and humans, highlighting a previously undescribed beneficial regulatory role for L1 activity.'
https://www.embopress.org/doi/full/10.1038/s44318-024-00175-5
If you're thinking "hey, what I need right now is more dystopia", this is the novel for you.
Tools
"To address these issues, we present a scalable and reproducible pipeline for Proximity Labeling-based proteomics (Fig. 1), incorporating automated enrichment of biotinylated proteins in a 96-well plate format and an optimized proteomics method for reproducible protein quantification."
#Proteomics
https://www.embopress.org/doi/full/10.1038/s44320-024-00049-2
I picked this one up by chance at a bookstore in Kyoto, Kobo Abe's The Ark Sakura. It opens with a grifter selling.. fake insects & flows into a story of a DIY dystopia, prominently featuring a toilet.
Recommended.
'Combining our amphioxus dataset and publicly available data from the mouse, zebrafish, tunicate, sea urchin and sea anemone, we uncovered a tripartite origin of the chordate CNS from anterior, posterior and NMP populations (Extended Data Fig. 7c).'
'The results of these efforts were extraordinary, however. The images revealed jumping spiders, weevils, dragonfly nymphs, and myriad other arthropods in exquisite detail, from an unprecedentedly personal perspective.'
'A scene from “The Tales of Hoffmann,” a Powell-Pressburger collaboration.
Credit: Rialto Pictures/Studiocanal'
https://www.nytimes.com/2024/06/21/movies/powell-pressburger-moma.html
"Here, we provide evidence for a new metabolic mechanism of ECM regulation driven by the upload of CAF-secreted lactate. Lactate-induced α-KG is exploited by P4H collagen prolyl-hydroxylase, impacting on collagen deposition. Moreover, we identified a type I collagen/DDR1/STAT3 axis as a signaling node required to promote a collagen-dependent achievement of pro-metastatic features in stromal lactate-reprogrammed PCa cells."
Ippolito et al @emboreports
https://www.embopress.org/doi/full/10.1038/s44319-024-00180-z
'Researchers have proposed that the methylation status of pectin can be sensed to control growth (Anderson and Kieber, 2020). However, how external signals interact with demethylated pectin molecules in the extracellular matrix is still poorly understood.'
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
