Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
"To characterize cell-type-specific transcriptional heterogeneity in active Crohn’s disease, we profiled 720,633 cells from the terminal ileum and colon of 71 donors with varying inflammation status."
#Immunology #MucosalImmunology #crohnsdisease
https://www.cell.com/immunity/fulltext/S1074-7613(23)00012-2
Thiago Carvalho
boosted
"There’s only so much funding you can ask individual faculty to obtain given scarce federal support."
My latest story for @sciencemagazine—about the postdoc salary situation. #academicchatter #ScienceMastodon #postdoc
https://www.science.org/content/article/postdocs-need-raises-who-will-foot-bill
Thiago Carvalho
boosted
"We have no one to blame but ourselves if we don’t give people credit for collaborating - when we hire them, when we promote them, when we give them our respect and recognition as scientists."
@CoriBargmann on the #EMBOPodcast
https://www.embo.org/podcasts/our-special-feature-as-humans-is-communication/
"Here, among seemingly unending geological strata, we can gaze into what the natural philosopher John Playfair called ‘the abyss of time’, a description he made after he, James Hall and James Hutton in 1788 observed layered geological aeons in the rocky outcrops of Scotland’s Siccar Point – a revelation that would eventually lead Hutton to become the founder of modern geology. In the Rift Valley, this vertical, tilted way of seeing is all the more powerful because the story of the Rift is the story of all of us, our past, our present, and our future."
https://aeon.co/essays/the-rift-valley-tells-the-entire-human-story-from-the-start
"The current model for GVHD holds that disease is maintained through the continued recruitment of alloreactive effectors from blood into affected tissues. Here, we show, using multiple approaches including parabiosis of mice with GVHD, that GVHD is instead primarily maintained locally within diseased tissues."
Sacirbegovic et al @ImmunityCP https://www.cell.com/immunity/fulltext/S1074-7613(23)00013-4
Thiago Carvalho
boosted
A well-preserved #Neolithic knife, the blade was made of flint and fastened with birch tar in a wooden handle.
From the pile dwelling settlement at Wangen-Hinterhorn, Lake Constance, dating 3800-3500 BC.
On display at Archäologisches Landesmuseum Baden-Württemberg, Konstanz
Etching by Madalena
Thiago Carvalho
boosted
Looking for feedback on some new thoughts about Big Ideas in brain/mind research.
I've spent quite a long time researching and thinking about the history of brain/mind research in terms of the Big Ideas that have emerged. Pre-1960, it's pretty easy to list the big ideas that researchers had reached consensus around. Since 1960, that's harder to do. There's plenty of consensus around new facts (like umami is supported by receptor X on the tongue), but it's difficult to regard the things that brain researchers agree on as new, big ideas. At first, I (mis)interpreted this as a paucity of new ideas, but I no longer think that's correct - I've found a ton. Instead, I now believe that they are there but we haven't arrived at consensus around them.
I'm wondering: Why might have researchers arrived at more consensus around Big ideas introduced 1900-1960 vs 1960-2020? Obviously there's the filter of history and the fact that it takes time to work things out. But is there more to it than that? For example, have the biggest principles already been discovered? And so we are left with more of a patchwork quilt?
A sample of big ideas pre-1960ish with general consensus
*) Nerve cells exist (it's not a reticulum)
*) Neurons propagate info electrically and then chemically between them
*) DNA > RNA > Protein is a universal genetic code or all living things
*) Explaining behavior needs intermediaries between stimuli and responses (cognitive maps/minds)
A sample of big ideas with no general consensus introduced post-1960ish:
*) Cortical function emerges from repetitions of a canonical element
*) The brain is optimized for goal-directed interactions with the environment in a feedback loop (prediction/embodiment/free energy)
*) The brain is a complex system with emergent properties that cannot be understood via reductionist approaches
*) Fine structural detail in the brain (the connectome) matters for brain function
I'd love to hear your thoughts.
Thiago Carvalho
boosted
Out today in Nature Human Behaviour: "A systematic review and meta-analysis of the evidence on learning during the COVID-19 pandemic" with @betthaeuser and Anders Bach-Mortensen https://www.nature.com/articles/s41562-022-01506-4
Thiago Carvalho
boosted
Reading in (online) journal club:
Jansson and Wu @NatureRevMicro@twitter.com
Soil viral diversity, ecology and climate change
#soil #SoilHealth #virus #biodiversity #ClimateChange #ecology
https://www.nature.com/articles/s41579-022-00811-z#Sec3
Thiago Carvalho
boosted
"Approximately a quarter of eukaryotes are infected with the bacterium Wolbachia." !!!!!
"we show that Wolbachia infection supports fly development and buffers against nutritional stress. Wolbachia infection across several fly genotypes and a range of nutrient conditions resulted in reduced pupal mortality, increased adult emergence, and larger size."
Lindsey et al. 2023 https://www.biorxiv.org/content/10.1101/2023.01.20.524972v1
Wow. #Drosophila #Wolbachia
Thiago Carvalho
boosted
Preprints are a great way to get community feedback on your research. To support discussion of preprinted work, ASAPbio & @PREreview_@twitter.com will host journal clubs for #preprints not yet submitted to a journal. Propose your preprint & get feedback on your work: https://buff.ly/3iQX7UA
"We have no one to blame but ourselves if we don’t give people credit for collaborating - when we hire them, when we promote them, when we give them our respect and recognition as scientists."
@CoriBargmann on the #EMBOPodcast
https://www.embo.org/podcasts/our-special-feature-as-humans-is-communication/
"Considering the vastness and complexity of Amazonia, it is hard to see how Wallace could have gained the insights he did after working in the region for only four years, had he not paid close attention to local knowledge."
Thiago Carvalho
boosted
"The paper costume prints are mostly made from real costumes (with the exception of the long dress, which is a smaller scale model) , worn by actors in a film project and subsequently smashed, inked and printed on cotton paper."
Colograph by Madalena
Thiago Carvalho
boosted
RT @FEMSmicro@twitter.com
Just a few more days to submit your abstract!
The deadlines for abstract & grant applications are around the corner.
Looking forward to joining us in Hamburg for #FEMS2023?
Submit your contribution by 1 February 2023, 11:59 PM CET via: https://www.fems2023.org/abstracts
Thiago Carvalho
boosted
Iris Lähdeniemi and Jennifer Devlin develop a reproducible and rapid tumour-lung colonisation model to study an aggressive subset of non-small cell lung #cancer (NSCLC):
#NSCLC #Carcinoma #Histopathology #Metastasis #PreclinicalModel #Science #BiologyOpen #Biology #AcademicMastodon
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
