Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
'One of the strategies to limit bacteria growth is to stop absorbing and transporting iron from the intestines - during an active infection, available iron drops dramatically (as do zinc and manganese). That’s a really effective broad-spectrum defense - as far as I know, the only human bacterial pathogen that doesn’t actually seem to need iron is the Lyme disease spirochete Borellia burgdorferi, and it makes up for that by requiring manganese instead.'
Thiago Carvalho
boosted
Climate activist jailed for eight weeks for contempt of court, because he refused to apologize for saying the reason they were demonstrating, the climate, during the trial.
They were forbidden from mentioning climate during the trial for demonstrating.
HOLY SHIT, BRITAIN IS A FAILED STATE
Thiago Carvalho
boosted
Mere months into the fatcat fascist's Twitter takeover, and Elon Musk, the supposed wizard of capitalism, is rationing your tweets like you're a muzhik in a breadline, & he's the Politburo.
“the daily update limit is further broken down into smaller limits for semi-hourly intervals.” Retweets also count toward that limit." 🤣
Thiago Carvalho
boosted
This Saturday is #InternationalDayofWomenandGirlsinScience so revisit this fantastic interview with Professors Joan Heath, Suzanne Cory & Joan Steitz talking about being #WomenInScience from the swinging '60s to present day!
https://journals.biologists.com/dmm/article/15/5/dmm049609/275582/
Thiago Carvalho
boosted
From @STAT re: House Energy & Commerce meeting.
NIH's Tabak laid out the next steps following proposals by biosecurity, ethics, and infectious disease experts to bolster government oversight of pathogen research that could make viruses more transmissible. Once the proposals are finalized, Tabak will write a memo to HHS Secretary Xavier Becerra, who will then consult the White House, and then the framework will be implemented.
Thiago Carvalho
boosted
And @battlingbeaver tells me I should have introduced myself before I just jump in and start posting.
Sorry! I'm Tara. I'm an infectious diseases researcher and Associate Prof at the University of Toronto, and I'm the lead of COVID-19 Resources Canada.
We do the Canadian COVID Forecast, Canadian COVID data reporting, the Canadian Excess Mortality Tracker, and of course, COVID Conversation Zoom sessions supported by me and other volunteer scientists.
It's great to be here at last!
"Here, we identified an endogenous cGAS-like enzyme in Pseudomonas aeruginosa that generates 3′,3′-cGAMP during phage infection, signals to a phospholipase effector, and limits phage replication."
Like #SARSCoV2 before it, #H5N1 is also finding farmed mink to be a welcoming host.
"In Spain, the virus appeared to spread from mink to mink. It also contained an unusual mutation that might be a sign of adaptation to mammals, scientists reported in a recent paper in the journal Eurosurveillance."
cc @n8_upham
https://www.nytimes.com/2023/02/08/health/avian-flu-mink-h5n1.html
Thiago Carvalho
boosted
Descending Geese, Katata #ukiyoe #hiroshige https://www.wikiart.org/en/hiroshige/descending-geese-katata
Thiago Carvalho
boosted
The media spectacle of #GenerativeAI (in which AI companies' breathless claims of their software's sorcerous powers are endlessly repeated) has understandably alarmed many #CreativeWorkers, a group that's already traumatized by extractive abuse by media and tech companies.
If you'd like an essay-formatted version of this thread to read or share, here's a link to it on pluralistic.net, my surveillance-free, ad-free, tracker-free blog:
https://pluralistic.net/2023/02/09/ai-monkeys-paw/#bullied-schoolkids
1/
Thiago Carvalho
boosted
Bayer recruits Roche veteran Bill Anderson to be its next CEO and replace Werner Baumann
https://www.fiercepharma.com/pharma/bayer-taps-roche-vet-anderson-its-next-ceo-pushing-out-baumann
"The strong dependence on T cells in MS animal models (experimental autoimmune encephalomyelitis, EAE) and the absence of antibodies in MS have long driven the assumption of MS being orchestrated by T helper cells (12), making those the most plausible therapeutic targets. But anti-CD20 therapies have been a game changer in the MS field."
#Immunology #MultipleSclerosis #MonoclonalAntibody #Autoimmunity
Thiago Carvalho
boosted
If you're trying to convince your Canadian friends to get set up on Mastodon but they don't know where to start, pass along the link to this listing of Canadian instances: #topoli #onpoli #cdnpoli
https://mastodonserver.ca/
"By conducting a pangenomic screen of the plant pathogen #Pseudomonas syringae, we found 13 type III effectors that potentially possess NADase activities, indicating that NAD+ manipulation is an important virulence mechanism."
"Among other things, this would mean reforming the agency’s much-maligned communications apparatus and honing its ability to capably respond to public health emergencies in a way that it has singularly failed to do during the Covid pandemic. If enacted, this would represent the kind of top-to-bottom revamp that rarely, if ever, happens at most federal agencies."
@gregggonsalves @thenation
https://www.thenation.com/article/society/cdc-reform-rochelle-walensky/
Thiago Carvalho
boosted
Lady Charlotte Hugonin Murchison died February, 9 1869. An avid fossil collector, she introduced her husband Sir Roderick Impey Murchison to the world of #geology. The "Ammonites Murchisonae" is named after her.
Thiago Carvalho
boosted
#CellMigration for house cleaning!
Immune cell (i.e. #DendriticCell), moves to remove 2 death cells (arrows)
This is pretty much what happens in our body when normal tissue cells die, they are scanned & removed by leukocytes (also macrophages)
#scicomm @cellcommlab @focalplane
Thiago Carvalho
boosted
How a Dutch "Dementia Village" Improves Quality of Life with Intentional Design
"Vaccines that resulted in speedy delivery of antigens to follicles preserved intact antigen and generated better antibody responses. These findings may have implications for the design of vaccines against difficult to neutralize or genetically variable pathogens"
#Immunology #ImmunologicalMemory #Antibody #GerminalCenter #Bcells #Vaccine
Thiago Carvalho
boosted
Our February issue is online today!📢
👉 Read our articles on #AlzheimersDisease, #stroke, #CADASIL, #leukemia, #Qfever, #ChronicKidneyDisease, #DiabeticWoundHealing (our cover) and more!
👉 Review on #PanethCells in intestinal homeostasis & organismal health, Commentaries on the functions of the #Elongator in health & disease, and on the development of allogeneic #iPSC -based therapy
🗞️ Fully #openaccess: https://www.embopress.org/toc/17574684/2023/15/2
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
