Thiago Carvalho @cyrilpedia@qoto.org

@MarkHanson At least they have a sense of humor

Serendipity & the discovery of tyrosine kinases:

"In analysing the phosphoaminoacids released by partial acid hydrolysis of polyoma virus middle T phosphorylated in vitro, Hunter used an old batch of pH 1.9 electrophoresis buffer; it so happens that phosphothreonine and phosphotyrosine do not separate on electrophoresis at pH 1.9 in acetic acid/formic acid/water buffer, but do separate at the lower pH of ‘aged’ buffer, from which the more volatile acetic acid has escaped (T Hunter, personal communication; Ushiro and Cohen, 1980)."

https://www.nature.com/articles/1208077

Hallmarks of neurodegenerative disease

"In this review, we argue that a set of hallmarks define NDDs, namely: pathological protein aggregation, synaptic and neuronal network dysfunction, aberrant proteostasis, cytoskeletal abnormalities, altered energy metabolism, DNA and RNA defects, inflammation, and neuronal cell death"

https://www.cell.com/cell/fulltext/S0092-8674(22)01575-6

"In the early 1950s, Dulbecco had been convinced by Max Delbrück, one of the founders of molecular biology, that animal viruses could be studied by the same quantitative approaches that had been used to study the replication of bacteriophages."
(From 'The Road to Src'

https://www.nature.com/articles/1208077

Somewhere deep in Navarra

"(...) but given that the Nobel Committee had a maximum of two names to award for the discovery of HIV, the choice of the 5′ and 3′ authors on the first paper (Barré-Sinoussi et al., 1983) seems just."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127708/

'Surprisingly, DAF-2 degradation specifically in the hypodermis improves memory in both young and aged C. elegans through the hypodermal expression of the diffusible Notch ligand, OSM-11.'

#Celegans #ageing

https://www.biorxiv.org/content/10.1101/2023.02.16.528821v1

"Ever since, he has been exploring organoid opportunities — in drug screening, disease modelling, clinical trial design and personalized medicine — in his academic lab, through biotechs and via scientific advisory boards. When he was offered the job as the head of Pharma Research & Early Development (pRED) at Roche, he jumped at the chance to take this organoid research to the next level."

https://www.nature.com/articles/d41573-023-00030-y

'Now, scientists have discovered that Leonardo did detailed experiments that sought to illuminate the nature of gravity a century before Galileo and some two centuries ahead of Newton’s making its investigation an exact science. The scientists’ study of his gravitational ideas and experimentation was published earlier this month in the journal “Leonardo.”

#HistoryScience #HistoryOfScience

https://www.nytimes.com/2023/02/17/science/leonard-da-vinci-gravity.html?action=click&module=Well&pgtype=Homepage&section=Science

"Like London’s fabled buses, you wait an age for a good book on England’s 17th century of civil wars, regicide and revolution — and then two, even three, come along almost at once."

https://www.ft.com/content/4cc66568-c1b8-4d67-b076-db1654a41496

"The lack of appropriate neutralizing antibodies recognizing IL-2RG has made it difficult to thoroughly interrogate the role of γc cytokines in inflammatory and autoimmune disease settings. Here, we generated a γc cytokine receptor antibody, REGN7257, to determine whether γc cytokines might be targeted for T cell–mediated disease prevention and treatment."

#immunology #cytokine #Monoclonal

https://www.science.org/doi/10.1126/scitranslmed.abo0205

'These findings support the continued development of mRNA-1893 against Zika virus, which was well tolerated at all evaluated dose levels and induced strong Zika virus-specific serum nAb responses after two doses, regardless of baseline flavivirus serostatus.'

#Zika #immunology #Virology #mRNA #Vaccine

https://www.sciencedirect.com/science/article/abs/pii/S1473309922007642