Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Details
"El problema de diseñar proteínas está resuelto. El reto es saber formular el problema que queremos resolver. Necesitamos una hipótesis molecular. Y para eso hay que comprender el origen de la enfermedad."
“Alongside the desacralisation and secularisation of public life,” Rovelli argues, “which passed from the hands of divine kings to those of citizens, came the desacralisation and secularisation of knowledge… law was not handed down once and for all but was instead questioned again and again.”
Thiago Carvalho
boosted
How Many Sirtuin Genes Are Out There? Evolution of Sirtuin Genes in Vertebrates With a Description of a New Family Member https://doi.org/10.1093/molbev/msad014 #science #evolution #biology #genome #SciComm #evolgen_paper
Thiago Carvalho
boosted
"The lack of appropriate neutralizing antibodies recognizing IL-2RG has made it difficult to thoroughly interrogate the role of γc cytokines in inflammatory and autoimmune disease settings. Here, we generated a γc cytokine receptor antibody, REGN7257, to determine whether γc cytokines might be targeted for T cell–mediated disease prevention and treatment."
Thiago Carvalho
boosted
"Ever since, he has been exploring organoid opportunities — in drug screening, disease modelling, clinical trial design and personalized medicine — in his academic lab, through biotechs and via scientific advisory boards. When he was offered the job as the head of Pharma Research & Early Development (pRED) at Roche, he jumped at the chance to take this organoid research to the next level."
"Together, our findings indicate that the AIM assay can be an effective tool for relative quantification of murine Ag-specific CD4+ T cells to protein vaccination, while demonstrating its limitations during conditions of acute and chronic infection."
“When the doctors switched off the life support machines, his mom climbed into bed beside him and I held my son’s hand as he passed away,” Puerta says. “This wasn’t an overdose because Daniel didn’t know what he was taking. He was intentionally deceived. He was poisoned.”
https://www.ft.com/content/bd1b1614-8407-4447-a0e3-3723368fbbf8
Thiago Carvalho
boosted
#Adipocyte #autophagy limits gut #inflammation by controlling #oxylipin and #interleukin IL-10
Katja Simon and coworkers
https://www.embopress.org/doi/10.15252/embj.2022112202
Thiago Carvalho
boosted
Blood Vessel Organoids for Development & Disease
Self-organizing capillary blood vessel #Organoid #EndothelialCell+#Pericyte (+Astrocyte for #BBB)
Transplant to gain vascular hierarchy
Organotypism Through Genetic Drivers
Dr. Josef Penninger lab Circ Res 2023
https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.122.321768
Saint in Pamplona realizes what happened to Jake Barnes in "The Sun Also Rises"
Thiago Carvalho
boosted
Postdoc (m/f/d) Tumor Biology - 23/02 @LeibnizFLI
#ScienceJobs #job
Jena #Germany #Researcher
https://jobrxiv.org/job/leibniz-institut-fur-alternsforschung-fritz-lipmann-institut-e-v-fli-27778-postdoc-m-f-d-tumor-biology-23-02/?feed_id=38600
Thiago Carvalho
boosted
#OtD 20 Feb 1988 20k people in Manchester marched against Margaret Thatcher's homophobic section 28 law, which made it illegal for public bodies to "promote" homosexuality, including teaching its "acceptability" in school
Thiago Carvalho
boosted
Notch signaling in development and homeostasis
In their 'Development at a glance' article and poster, Oren Gozlan and David Sprinzak provide a brief overview of the Notch signaling and function in development and homeostasis
Thiago Carvalho
boosted
This is *not* the way scientific papers typically begin:
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We are running out of time. Ecosystems across the planet are being destroyed at an accelerating rate. The life sciences – once a field dedicated to the study of living systems and our interactions with them – are increasingly becoming sciences of the dead. Up to one million species are currently threatened with extinction, many of them within decades.
_________________________
It's a very good sign, however, an indication that at least some scientists are now ready to speak boldly and unequivocally about the greatest emergency our species has ever faced.
SEE THE FULL PAPER -- https://elifesciences.org/articles/83292
If you're applying for funding via the EU Horizon program have a look at this: the European Commission has posted a list of common do's & don'ts.
"El laboratorio de David Baker en la Universidad de Washington (Estados Unidos) va un paso más allá. Ha desarrollado varios sistemas de inteligencia artificial abiertos que crean proteínas que nunca han existido en la naturaleza."
Le Floc’h et al at Regeneron generated an anti-common gamma chain monoclonal that blocks signaling.
"Treatment of nonhuman primates with REGN7257 suppressed NK cells and T cells without affecting granulocytes, erythrocytes, or platelets."
Thiago Carvalho
boosted
RT @sivajothy
The call for symposia at ICE (The International Congress of Entomology) in Kyoto 2024 is now open. ( http://shorturl.at/cxyA8 ). please retweet.
Thiago Carvalho
boosted
📢 Don't miss: Tuuli Lappalainen @tuuliel_lab (@nygenome @KTHuniversity @scilifelab) will speak at our #DahlemColloquium!
📜 Functional variation in the human #genome: lessons from the #transcriptome
📆 27. FEB, 11:00 AM (CET)
📍 @MPI_MolGen, #Berlin
🔗 https://www.molgen.mpg.de/events/33625/3967495
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
