Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
THE CASE FOR FREE-RANGE LAB MICE
🧵 A THREAD on my new @NewYorker story
https://www.newyorker.com/culture/annals-of-inquiry/the-case-for-free-range-lab-mice
Thiago Carvalho
boosted
Modeling work from Gjorgjieva’s lab on turtle visual cortex reveals the role of weak synaptic connections among neurons:
“rare strong connections support sequence propagation, while dense weak connections modulate propagation reliability.”
“Applying external inputs to specific neurons in the sparse backbone of strong connections can effectively control propagation and route activity within the network.”
Thiago Carvalho
boosted
This paper provides an excellent overview
https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-021-01184-0
"Si dos medicamentos se parecen demasiado, por el nombre o el envase, el hospital puede buscar una alternativa con menores riesgos. A veces esto no es posible, y entonces se utilizan otras medidas como las llamadas tall man letters (las letras del hombre alto, en inglés), que destacan en mayúsculas las letras diferentes en nombres parecidos. Un ejemplo seria “cloZApina” y “cloTIApina”, dos antipsicóticos."
Thiago Carvalho
boosted
'I was struggling to update my corkboard when I read this exquisitely pulpy line: “Lawler was a New York blue blood who married a nouveau riche nobody named Constantine Psomas — a.k.a. the can man.” Warmth filled my guts like whiskey. I didn’t need a map. Mosley was driving me to Rikers in a cream-colored Bianchina, and Mingus was playing on the stereo. I was along for the ride.'
"The idea that I wanted to address is the impression that some parts of the public have now that vaccine development is apparently not all that hard."
https://www.science.org/content/blog-post/there-are-vaccines-and-there-are-vaccines
"We identified and validated APOBEC3A and APOBEC4 as novel #ribosome biogenesis factors through our laboratory's established screening platform for the discovery of regulators of nucleolar function in MCF10A cells."
@gpollara Comparing the IRF1 deficiency phenotype in this paper to the gamma interferon pathway mutants extensively described might generate some clues
Thiago Carvalho
boosted
Influenza-trained mucosal-resident alveolar macrophages confer long-term antitumor immunity in the lungs
"Thus, studies of MSMD (Mendelian susceptibility to mycobacterial disease ) have revealed that human antimycobacterial immunity is a genetically controlled quantitative trait: the lower the level of IFN-γ activity, the more severe the disease and the higher its penetrance"
#immunology #InfetionImmunity #InfectiousDisease #mycobacterium #tuberculosis
Thiago Carvalho
boosted
RT @cggbamford
As far as discussions on virus taxonomy - or taxonomy in general - go, this is a great read and highlights challenges and opportunities in organising the virosphere https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001922
Thiago Carvalho
boosted
Population Genetic Considerations Regarding Evidence for Biased Mutation Rates in Arabidopsis thaliana https://doi.org/10.1093/molbev/msac275 #science #evolution #biology #genome #SciComm #evolgen_paper
Thiago Carvalho
boosted
Immunotherapy Physician Scientist Fellow
#ScienceJobs #job
Seattle #UnitedStatesUS #PostdoctoralFellow
https://jobrxiv.org/job/fred-hutchinson-cancer-center-27778-immunotherapy-physician-scientist-fellow/?feed_id=38648
Thiago Carvalho
boosted
This morning in 1971, a teletype operator at the National Emergency Warning Center in Cheyenne Mountain, Colorado, mistakenly transmitted a message via the Emergency Broadcast System notifying radio and TV stations nationwide the United States was under attack. http://conelrad.blogspot.com/2010/09/code-word-hatefulness-great-ebs-scare.html
Thiago Carvalho
boosted
Genome editing for the potential of curing diseases is taking off in directions that were not anticipated. I reviewed its recent and accelerated pace of progress
https://erictopol.substack.com/p/towards-genome-editing-cure-of-genetic
"In his 1821 book, “A Defense of Poetry,” Percy Shelley writes that an artist must learn to imagine what he knows. For many artists, the verdict of macular degeneration might have been disabling, or at least discouraging. For Jules, it was an invitation to imagine what he knew."
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
