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Progress.

"In my professional lifetime, neonatal mortality has gone from 30 per thousand to 5 per thousand. The babies I couldn’t take care of when I was a house staff now largely go home and live full lives. You wouldn’t believe how robust a baby is and how well they can heal and recover from real challenges."

jci.org/articles/view/168557

So happy to finally see this collaboration with Rion Correia and @alainbarrat out. The distance backbone is a unique, algebraically-principled network subgraph that preserves all shortest paths. We were were excited to find out (with and other data) that the backbones of contain large amounts of redundant interactions that can be removed with very little impact on and spread.



:

dx.plos.org/10.1371/journal.pc

Had a great time yesterday opening the Algarve University Hospital Center's (CHUA) conference, speaking on the research origins of some of today's key drugs & the limits of translation.

And Rous' hen, of course :)

"Students and academics at Oxford university have called for a sweeping review of policies around its relationship with donors, following revelations that the elite institution courted the Sackler family even after others cut ties."

ft.com/content/6a42e764-46a1-4

"The UK Department for Business, Energy and Industrial Strategy is quietly returning £1.6 billion (US$1.9 billion) in funding to the Treasury that had been earmarked for research collaborations with the European Union in its 2022–23 budget. But the government swears that the money is not lost to UK science."

nature.com/articles/d41586-023

"Ventura usa a mentira para fazer passar a sua mensagem e, quando apanhado a mentir, demonstra não ter passado pela fila daquilo que permanentemente apregoa: vergonha."

publico.pt/2023/02/24/opiniao/

@bufalo1973@xarxa.cloud @seatsixtyone I scream with it, since I live in Lisbon and one of my best friends is in Badajoz (and Merida's Roman ruins and museum are fantastic). The absence of a Lisbon Madrid link is absurd. It used to exist, train links are worse now than they were 20 years ago! But sure let's build more airports...

Microbe-mediated intestinal NOD2 stimulation improves linear growth of undernourished infant mice

science.org/doi/10.1126/scienc

"Here, we show that in both normal and malignant B-cells, CD20 down-regulation commonly occurs via alternative splicing in its 5′ UTR."

biorxiv.org/content/10.1101/20

RT @skeptencephalon
@ZebrafishRock

Proud to announce work by Inbal Shainer ⁦⁦@IShainer⁩, Enrico Kühn & collaborators:⁩ ⁦⁩

A single-cell resolution gene expression atlas of the larval zebrafish brain | Science Advances science.org/doi/10.1126/sciadv

Exciting.
Dynamical states of self-organized waves in a giant single-celled organism feeding on light biorxiv.org/content/10.1101/20

Analysis of copy number variation following platinum-based chemo.

"Here, we demonstrate that platinum-based chemotherapies also leave a type of larger mutational footprints in the genomes of exposed cells. These consist in an increase of chromosomal fragments of copy number between 1 and 4 and length below 40 Mb, possibly resulting from an increased frequency of double strand breaks in the chromosomes of the cells of exposed patients."

journals.plos.org/plosgenetics

In other news: "Quality research needs live researchers", "Quality research requires working researchers".

nature.com/articles/s41562-022

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