Thiago Carvalho @cyrilpedia@qoto.org

Expanding a statistical approach called Mendelian randomization to include multiple variables may help researchers to identify new molecular causes of specific traits. https://elifesciences.org/articles/86416?utm_source=mastodon&utm_medium=social&utm_campaign=organic_insights

Targeted Protein Upregulation of STING for Boosting the Efficacy of Immunotherapy

https://onlinelibrary.wiley.com/doi/10.1002/anie.202300978

'A big reason people don’t stay in public health is money. Salaries are small. Bureaucracies are large. Since the pandemic, abuse has also been on the rise. And in more than half the states, lawmakers have curtailed public health experts’ ability to make and carry out policies. Castrucci said that’s like using a jackhammer to shatter our own collective safety.'

https://www.politico.com/newsletters/politico-nightly/2023/03/07/were-not-prepared-for-the-next-public-health-crisis-00085993

Interesting new paper from Orian Shirihai's group in @embojournal
"Inhibition of ATP synthase reverse activity restores energy homeostasis in mitochondrial pathologies"
https://www.embopress.org/doi/full/10.15252/embj.2022111699

Orian & I discussed his classic work on the mitochondrial life cycle (also published in EMBO J) on an episode of the #EMBOPodcast 🎧 👇

#mitochondria #mitophagy #metabolism

https://www.embo.org/podcasts/fuse-or-die-a-conversation-with-orian-shirihai/

Interview (in Portuguese) with my friend @joanagsa
on equality, implicit bias, and the pernicious myth of meritocracy in academia.

"No entanto, é raro encontrar o mesmo nível de escrutínio ou de julgamento quando gerações de homens brancos promovem outros homens brancos porque são da mesma família ou porque os pais eram amigos de infância. Porque nos lembramos mais de uns casos do que de outros, o nosso cérebro constrói uma narrativa que se perpetua."

https://activa.sapo.pt/mulheres-inspiradoras/2023-03-08-dia-da-mulher-palavras-de-joana-goncalves-de-sa/#&gid=0&pid=1

Behold 900+ Magnificent Botanical Collages Created by a 72-Year-Old Widow, Starting in 1772

https://www.openculture.com/2023/03/behold-900-magnificent-botanical-collages-created-by-a-72-year-old-widow-starting-in-1772.html

A shrine among trees on a moor #utagawahiroshige #ukiyoe https://www.wikiart.org/en/hiroshige/a-shrine-among-trees-on-a-moor

A study weighs introducing a transmissible vaccine against rabies to vampire bats. The candidate virus causes lifelong infections in bats and could serve as a vaccine vector, reducing the size, frequency, and duration of rabies outbreaks by 50 to 95%. In PNAS: https://www.pnas.org/doi/10.1073/pnas.2216667120

Postdoc in experimental evolution @IdeevL

A #PostDoc researcher position (12 month, renewable once) in #ExperimentalEvolution is available from June 2023.

https://jobrxiv.org/job/universite-paris-saclay-ideev-institute-of-ecology-and-evolution-egce-27778-postdoc-in-experimental-evolution/?feed_id=40460

#ScienceJobs #job @INRAE_Bioger @UnivParisSaclay #evolution #genomi...
https://jobrxiv.org/job/universite-paris-saclay-ideev-institute-of-ecology-and-evolution-egce-27778-postdoc-in-experimental-evolution/?feed_id=40460

My latest Clinical Pipeline column for #NatureMedicine is now online. A new take on heart failure using iPSC derived cardiomyocytes.

#drugdevelopment #cardiology #stemcells #regeneration

https://www.nature.com/articles/d41591-023-00027-5

Researchers need guidance on what is meant by "the data" and on where they should archive datasets.

This letter is a call for some joined-up thinking: https://rdcu.be/c6ZWh

Scientists in various fields have expressed confusion to me about what to archive and where in light of recent mandates. If the point of data deposits is reuse not just compliance in the event someone ever has a problem with the paper, they need more guidance.

Nicola L. Stevenson et al. complete a future leader #review of the well-studied interactions between the #Golgi, #cilium and #extra cellular matrix, with a particular focus on how the interplay between all three compartments underpins healthy tissue.
https://journals.biologists.com/bio/article/12/2/bio059719/287059/The-factory-the-antenna-and-the-scaffold-the-three#Biology
#Science #BiologyOpen #AcademicMastodon

75% of scientists are burned out and pulling back on conferences, peer review, committee membership, etc https://www.nature.com/articles/d41586-023-00633-w

When scientists set boundaries, it not only improves their own personal well-being, but also creates norms that limits are acceptable and healthy

Study shows that morphogens in #Drosophila blastoderm control formation of cell densities along the #DVaxis that in turn is necessary for fine-tuning #morphogen gradient levels; #frazzled & #GUKholder are key effectors in this process #PLOSBiology https://plos.io/3YKufMO