Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
RT @IdoAmitLab
Very impressive work, with potential to deepen our understanding of cell-cell communications.
https://www.biorxiv.org/content/10.1101/2023.03.16.533003v1
'In a study published by the American Cancer Society in March, researchers estimated that in 2023, 153,000 people in the United States would be diagnosed with colorectal cancer. Of those cases, about 13 percent would be among people under 50 — representing a 9 percent increase in cases in this age group since 2020.'
https://www.nytimes.com/2023/03/20/well/colon-colorectal-cancer-symptoms-screening.html
Thiago Carvalho
boosted
my group is finally real! https://child-health-research.centre.uq.edu.au/research/computational-immunology @qldchildres @YUmmunology @LisaTom106 @tuong_lab
Fundamental physics questions:
"Peanut Butter Stirs an Old Debate: To the T.S.A., What’s a Liquid?"
https://www.nytimes.com/2023/03/20/travel/tsa-peanut-butter-liquid-security.html
Thiago Carvalho
boosted
RT @wolfgangkhuber
Postdoc position in spatial and single-cell computational biology for precision oncology at EMBL
Contribute your skills in data science, statistics, ML to an application of latest technologies to a large clinical collaboration on exciting new drug class
Thiago Carvalho
boosted
Mitochondrial damage activates the NLRP10 inflammasome
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RT @IIIBonn
We are super excited to share the newest publication from the Latz Lab @IIIBonn in @NatImmunol 🔥🎉
https://www.nature.com/articles/s41590-023-01451-y
A great collaboration with Franklin Zhong and @FISchmidtLab
Summary below, from twitterless 1st author Tom... 1/n
https://twitter.com/IIIBonn/status/1637848269681205248
Thiago Carvalho
boosted
The Harlem Hellfighters were a predominantly Black regiment in WWI. They confronted racism even as they trained for war, brought jazz to France, and battled longer than any other American unit. They also won the Croix de Guerre for their bravery. The medals can be seen in the colourized photo.
Thiago Carvalho
boosted
In my latest Clinical Pipeline column for Nature Medicine, a look at iPSC therapy for heart failure.
"Heartseed is not the only company currently performing clinical trials with iPSC-derived cardiomyocytes. Help Therapeutics in China is also using an approach with allogeneic iPSC-derived cardiomyocytes, and Göttingen University is running a trial for patients with end- stage heart failure using engineered heart muscle composed of a mixture of iPSC- derived cardiomyocytes and stromal cells."
Thiago Carvalho
boosted
Job alert:
@EMBOPress is recruiting a scientific editor for The @embojournal
The deadline is tomorrow (Mar 21)
Thiago Carvalho
boosted
"Colograph
The works presented here are created with alternative materials rather than etched on copper. From squashed paper costumes to packaging and leather book covers, objects are inked with different processes, both intaglio and planographic. Scales vary and are usually life-size." by @madparreira #Prints #Handmade #BookArt
Thiago Carvalho
boosted
Gerhard Richter, Seascape I (Seestück I), 1969 #museumarchive #museumofmodernart http://www.moma.org/collection/works/101596
Thiago Carvalho
boosted
Tools
"To complement existing tools of small-molecule-based inhibitors, we present a highly potent, novel catalytically-driven glucocorticoid receptors degrader, KH-103, based on proteolysis-targeting chimera technology."
Thiago Carvalho
boosted
From Carl June et al
"A fundamental limitation of T cell therapies in solid tumors is loss of inflammatory effector functions, such as cytokine production and proliferation. Here, we target a regulatory axis of T cell inflammatory responses, Regnase-1 and Roquin-1, to enhance antitumor responses in human T cells engineered with two clinical-stage immune receptors."
Thiago Carvalho
boosted
Protip:
If you're working on the Great Immunological Novel, make sure your characters from the 70s say "suppressor T cells" and not "Tregs".
(fm Benjamin Dreyer's wonderful 'Dreyer's English).
Thiago Carvalho
boosted
Thiago Carvalho
boosted
Antisemitism on Twitter has more than doubled since Elon Musk took over the platform – new research.
In the days after Elon Musk took over Twitter in October 2022, the social media platform saw a “surge in hateful conduct,” which its then safety chief put down to a “focused, short-term trolling campaign.” New research suggests that when it comes to antisemitism, it was anything but.
Rather, antisemitic tweets have more than doubled over the months since Musk took charge, according to research at tech firm CASM Technology and the Institute for Strategic Dialogue think tank conducted. https://theconversation.com/antisemitism-on-twitter-has-more-than-doubled-since-elon-musk-took-over-the-platform-new-research-201830
Today, in every-cell-is-an-immune-cell:
"STING activation in platelets was a critical driver of sepsis-induced pathology. Platelet-specific STING deficiency suppressed platelet activation and granule secretion, which alleviated sepsis-induced intravascular thrombosis and NETosis in mice."
Yang et al @ImmunityCP
Thiago Carvalho
boosted
Deer mice run comfortably at 25C, but as the temperature rises the tiny rodents begin to struggle and they begin overheating once the air temperature reaches 38C, which could be a big problem for the mini mammals in future climate scenarios #science #zoology #comparativephysiology #climatechange
https://journals.biologists.com/jeb/article/226/5/jeb245732/297090
You can read the full research at https://journals.biologists.com/jeb/article/226/5/jeb244847/297103
"Data is one more space where we need that attention to and cultivation of equality. We’ve lost sight of that. We’re still in this wild west, highly unregulated terrain where inequality is just piling up."
https://www.nytimes.com/interactive/2023/03/20/magazine/colin-koopman-interview.html
From 12/21: I spoke with Harmit Malik on the #EMBOPodcast about how he got started, mobile genetic elements, genomic defences, and (with @tlemberger) preprints.
"Just like many other important transitions in life, I think my transition from chemical engineering to biology was chaperoned by a fantastic mentor.
(...)
He made even dry topics seem very interesting - but when he was teaching about the Lac operon and the basic fundamentals of molecular biology I was completely transfixed. It became something that I felt I could not pass up the opportunity to see if this is something I could spend the rest of my career on."
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
