Thiago Carvalho @cyrilpedia@qoto.org

"We conclude that expression of TEs is tightly regulated in TILs during establishment of exhaustion and reprogramming by ICB. Analyses of TE expression on single cells and bulk populations open opportunities for understanding immune cell identity and heterogeneity, as well as for defining cellular gene expression signatures and disease biomarkers."
#Immunology #Immunotherapy

https://www.science.org/doi/10.1126/sciimmunol.adf8838?utm_campaign=SciMag&utm_source=Twitter&utm_medium=ownedSocial

"The whole episode left me wondering what purpose it serves to penalize those who want to stay at the same institution for multiple career stages. It’s often said in academia that 'moving around a lot is necessary.' But the reality is that moving is a huge barrier for many scientists, including those with spouses, children, aging parents, disabilities, and cultural backgrounds that emphasize a close-knit extended family community—the kinds of people academia is actively trying to recruit to its ranks."

https://www.science.org/content/article/i-didn-t-want-relocate-postdoc-fellowship-reviewers-penalized-me-it?utm_campaign=SciMag&utm_medium=ownedSocial&utm_source=LinkedIn

4% of ~58,000 individuals assessed carried an actionable gene variant that is linked with reduced lifespan, such as BRCA2 with associated reduced lifespan by 7 years and 7-fold risk of dying from various cancers

https://www.nejm.org/doi/full/10.1056/NEJMoa2300792?query=featured_home

Tickets for the Ig Nobel Face-to-Face event at MIT this coming weekend are sold out. But fear not — later this year, we will webcast a video-recording. https://improbable.com/2023/10/17/ig-nobel-face-to-face-event-at-the-mit-museum/

I've tried to straddle the line on Twitter, hoping to keep dialogue open across communities and avoid furthering the polarisation by leaving the Birdsite with no advocates for better practice.

But I'm out. Deleting account today. I've been primarily Mastodon since Nov 2022 anyways. Celebrating one year! #MastodonMigration #twitterMigration
https://www.nature.com/articles/d41586-023-03483-8

Our most read article from August is ‘Repetitive nociceptive stimulation elicits complex behavioral changes in Hirudo: evidence of arousal and motivational adaptations’ by Jessica Hoynoski & co.

Read the full research article: https://journals.biologists.com/jeb/article/226/16/jeb245895/325884

#Science #Biology #Zoology

It's going to take all the running in the world just to stand still.

"A machine-learning tool can easily spot when chemistry papers are written using the chatbot ChatGPT, according to a study published on 6 November in Cell Reports Physical Science1. The specialized classifier, which outperformed two existing artificial intelligence (AI) detectors, could help academic publishers to identify papers created by AI text generators."

https://www.nature.com/articles/d41586-023-03479-4?utm_medium=Social&utm_campaign=nature&utm_source=Twitter#Echobox=1699287337

"Uma startup de saúde ginecológica do Reino Unido lançou, recentemente, um tampão que funciona como um teste PCR para diagnóstico de doenças sexualmente transmissíveis (DST) nas mulheres. Segundo a empresa Daye, o tampão funciona como substituto do cotonete ou espéculo vaginal utilizados nos testes de rastreio e consegue igualmente identificar clamídia, gonorreia, microplasma, ureaplasma e tricomonas."

https://www.publico.pt/2023/11/06/p3/noticia/startup-britanica-lanca-tampao-detecta-doencas-sexualmente-transmissiveis-2069180

"Here, we describe an mRNA-based platform enabling delivery of pathogen-specific immunoglobulin A (IgA) monoclonal antibodies into mucosal secretions. The platform consists of synthetic mRNA encoding IgA heavy, light, and joining (J) chains, packaged in lipid nanoparticles (LNPs) that express glycosylated, dimeric IgA with functional activity in vitro and in vivo."

https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(23)00430-5

@Daojoan Really good long read last week on how the myth of "Man the Hunter" came about and how it got trashed by, you know, evidence.
https://www.scientificamerican.com/article/the-theory-that-men-evolved-to-hunt-and-women-evolved-to-gather-is-wrong1/

Wild opinion, but the majority of public school parents are normal people who work for a living and do not want genital-obsessed, home-schooling, social media stunting, adults in charge of their kids' education. https://www.thedailybeast.com/moms-for-liberty-candidates-taught-a-lesson-in-2023-elections

RT by @joseggusmao: Pergunta de uma jovem (negra) na audiência: “acha que eleições antecipadas podem dar força a partidos que ameaçam a democracia como o Chega?”

@passoscoelho “Não creio que o Chega seja um partido anti-democrático”. É esta mensagem para uma audiência de alunos do secundário?!

🐦🔗: https://nitter.cz/DuarteCosta5/status/1722186367168389448#m

[2023-11-08 09:36 UTC]

#^Mycorrhizal fungi: the roots of life on land


Buried in the soil lies a hidden network that transformed the planet and plays a vital role in ecosystems today
- by Aeon Video

Watch at Aeon

Postdoc in Mechanobiology

Department of Molecular Medicine and Medical Biotechnology, Federico II University of Naples, Italy

Passionate postdoc sought for mechanobiology research in a dynamic, multidisciplinary setting in Naples.

See the full job description on jobRxiv: https://jobrxiv.org/job/department-of-molecular-medi...
https://jobrxiv.org/job/department-of-molecular-medicine-and-medical-biotechnology-federico-ii-university-of-naples-italy-27778-postdoc-in-mechanobiology/?feed_id=64752