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'Using integrated single cell strategies, we demonstrate that acute PD-1 blockade induces extensive and selective local anti-inflammatory IgG1 plasma cell (PC) differentiation. Expansion of pre-existing IgG1 germinal center (GC) B cell and enhanced GC programming without memory B cell involvement reveals an isotype-specific GC checkpoint that blocks steady-state IgG1 antibody maturation'

biorxiv.org/content/10.1101/20

'But she was not finished with the tiny beasts, known as tardigrades. She brought them to her laboratory at the French National Museum of Natural History, where she and her colleagues hit them with gamma rays. The blasts were hundreds of times greater than the radiation required to kill a human being. Yet the tardigrades survived, going on with their lives as if nothing had happened.'

nytimes.com/2024/04/12/science

“Éramos escravas”, resume, enquanto sorve um chá, no apartamento que partilha com o marido nos arredores de Chaves. “Pagavam o que quisessem, para fazermos o que quisessem, no horário que quisessem.” Quantas eram literalmente “criadas para todo o serviço”, levadas (forçadas) a prestar até serviços sexuais aos senhores ou seus filhos?

publico.pt/multimedia/interact

"In endeavors like writing software, the cycle time is short. You can just try it and see if it works; if not, you have only lost a couple weeks. This doesn’t work in biology, chemistry, physics, and (non-software) engineering, where a typical project takes months to reach a go/no-go threshold and years to complete. A poor project chosen in haste can be hard to shed; inertia takes over and the sunk-cost fallacy is difficult to avoid."

cell.com/cell/fulltext/S0092-8

'The endosymbionts with the smallest genomes have lost so many genes that they lack the ability to do much at all on their own and start to resemble mitochondria and chloroplasts more than typical bacteria. How these hosts and endosymbionts integrate their biochemical and cell biological processes is largely unknown.'

journals.plos.org/plosbiology/

The one thing all great scientific discoveries involved is hard thinking, and that requires time. Seems obvious, yet as I read about how to make scientific #research better, more rigorous and reliable, I don't see enough discussion about this: more time to think - quite to the contrary. Scientists spend an ever increasing amount of time doing experiments, on admin tasks, writing grants, progress reports etc... to the expense of time to think. #Science #openscience #theory #reproducibility

“I spoke with a Google worker fired for protesting a $1.2 billion contract with Israel”

"Yeah, this was retaliation, like completely indiscriminate—people who had just walked by just to say hello and maybe talk to us for a little bit. They were fired." thehandbasket.co/p/google-work

Are you interested in how neuronal populations code external and internal signals to drive behavior? Join our lab as a postdoc! We are looking for people with a diverse set of skills, from computational to experimental. Our lab offers a friendly and collaborative environment, and the most advanced techniques. For more information, see ucl.ac.uk/cortexlab/positions

'In the US, Newman finds that the outstanding predictor of longevity is patchy birth records. Introducing proper records in the late 19th century reduced by more than two-thirds the number of babies who would eventually seem to reach the age of 110. That suggests that, until recently, seven out of 10 apparent supercentenarians were, in fact, younger than claimed.'

ft.com/content/912c2b53-65eb-4

[1/2] Surprising findings in brain research 🧠: As a team from #CharitéBerlin shows in #Science, thoughts in the human neocortex flow in one direction ⬆️, as opposed to the loops seen in mice 🔄. That makes processing information extra efficient. These discoveries could further the development of artificial neural networks.

👉 charite.de/en/service/press_re

@YangfanPeng #CharitéPaper #CharitéNeuro #research #neuroscience #ScienceMastodon #MachineLearning #ArtificialIntelligence #AI

'Researchers in Canada got most of what they were hoping for in the country’s 2024 federal budget, with a big boost in postgraduate pay and more funding for research and scientific infrastructure.'

nature.com/articles/d41586-024

Well done!

"According to the Swiss university, rankings often focus on measurable output, creating an incentive to increase the number of publications rather than prioritise the quality of content."

swissinfo.ch/eng/education/uni

168 proteomic databases/scripts/programs added to Pastel's Resource page in 2023

Here's a random selection from the webpage bit.ly/1J4g3CE

ekhidna2.biocenter.helsinki.fi | SANSparallel | interactive homology search against Uniprot

---
#proteomics #prot-other

Nuclear expert fears flooded radioactive dump sites in Siberia can threaten Arctic Ocean
Floodwaters in Tomsk region threatens to submerge the river banks in Seversk where highly radioactive liquid waste from the Soviet Union's nuclear weapons program for decades were injected into two unprotected underground reservoirs.
thebarentsobserver.com/en/nucl #Rosatom #Russia #Nuclear #nuclearWaste #Arctic

'Under the envisaged agreement, EU and UK citizens aged between 18 and 30 would be able to stay for up to four years in the destination country, the European Commission said in a detailed statement.'

theguardian.com/politics/2024/

'What exactly is happening in Scotland to explain this pattern, and are we (I say “we” given that I’ve lived in the nation for roughly a decade) really that different from other parts of the UK and Europe? The first issue to highlight is that life expectancy differs based on where you live. In Glasgow, life expectancy varies hugely between the richer and poorer parts of the city. In 2021, if you lived in Pollokshields West, life expectancy was 83 years, while in Greater Govan it was 65.4 – a gap of 18 years. Averages hide a deeper story linked to deprivation and inequality within Scotland. Where and how you live plays a crucial role in how long you live.'

theguardian.com/commentisfree/

'A pill taken once a week. A shot administered at home once a month. Even a jab given at a clinic every six months.

In the next five to 10 years, these options may be available to prevent or treat H.I.V. Instead of drugs that must be taken daily, scientists are closing in on longer-acting alternatives — perhaps even a future in which H.I.V. may require attention just twice a year, inconceivable in the darkest decades of the epidemic.'

nytimes.com/2024/04/17/health/

Boeing's outgoing CEO could get a "golden parachute" worth as much as $45 million.

The CEO before him got one worth $62 million on his way out the door in 2019.

America has socialism for the rich, harsh capitalism for everyone else.

From 1989 — 2021, typical working families in the US saw negligible increases in their real incomes and wealth.

Meanwhile, the wealthiest 1% became $29 trillion richer.

Trickle-down economics did not work.

It still does not work.

It will never work.

It's not meant to work.

NYT Newspeak...

Report

The New York Times directed its journalists to avoid using the words "genocide", "ethnic cleansing", "occupied territory", etc.

"Amid the internal battle over the New York Times’s coverage of Israel’s war, top editors handed down a set of directives."

theintercept.com/2024/04/15/ny

#NYTlies #US #Newspeak #Orwell ..

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