Thiago Carvalho @cyrilpedia@qoto.org

'How can we make sense of the fact that animal studies and early clinical trials seem to show promise, yet there is very limited official approval for these therapies? There are 2 possible explanations: One scenario is that the strict requirements of RCTs and regulatory approval are causing many potentially valuable treatments to be left behind. The other scenario is that both animal studies and early clinical trials may have limitations in their design, such as a lack of proper randomization and blinding, which affects their internal validity'

https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002667#sec027

'Clinical data supported a delayed onset of cognitive impairment in persons who were heterozygous for the APOE3Ch variant in a kindred with a high prevalence of autosomal dominant Alzheimer’s disease.'
https://www.nejm.org/doi/full/10.1056/NEJMoa2308583

"Strange though it may sound, the custom of telling the bees about a death in the household has been going on for centuries. It’s been recorded throughout the United Kingdom, as well as parts of France, Germany, Switzerland, and the Netherlands. Beekeepers in parts of New England still keep their hives abreast of certain events, particularly a passing."
https://www.atlasobscura.com/articles/telling-the-bees-death

'Researchers and activists in the trenches of the long fight against H.I.V. got a rare piece of exciting news this week: Results from a large clinical trial in Africa showed that a twice-yearly injection of a new antiviral drug gave young women total protection from the virus.'
https://www.nytimes.com/2024/06/21/health/lenacapavir-hiv-prevention-africa.html

I'd keep a hardcopy (not just an electronic backup) of all important protocols.
"An electronic lab notebook (ELN) is a software tool for documenting laboratory experiments, research data, and processes. ELNs are set to replace paper lab notebooks as part of the ongoing digital transformation"
https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1012170

"The Japan Society for the Promotion of Science (JSPS) also has funded short-term and long-term positions for postdoctoral researchers and visiting faculty to institutes throughout Japan."
https://www.elizabethtasker.com/faq

This in depth look at Clarence Thomas versus evolving standards of decency (and the 8th amendment) is stomach-churning, grotesque even by the rockbottom standard of originalists:

https://www.nybooks.com/online/2024/06/18/the-hollowing-of-the-eighth-amendment/

'Researchers have proposed that the methylation status of pectin can be sensed to control growth (Anderson and Kieber, 2020). However, how external signals interact with demethylated pectin molecules in the extracellular matrix is still poorly understood.'

https://elifesciences.org/articles/99053?utm_source=linkedin&utm_medium=social&utm_campaign=organic_insights

And now, for something completely different:
"While the role of flagellar motility in bacterial survival has been widely reported, its direct influence on the rate of evolution remains unclear. We show here that both production and operation costs contribute to elevated mutation frequencies."
#Preprint #Evolution
https://www.biorxiv.org/content/10.1101/2024.06.21.600093v1

'Nestled under the technical title "Commercial Determinants of Non-Communicable Diseases in the WHO European region” is a clear and frank report on how the profit-motive leads to 2.7 million preventable deaths a year, in Europe alone.'
https://canadahealthwatch.ca/2024/06/20/the-who-says-corporate-greed-is-causing-millions-of-preventable-deaths

<strong>Irvine Welsh: ‘If reading gives you comfort, you’re not doing it right’</strong>

"_The Scottish author on having his mind changed by Orwell, how Trainspotting was influenced by Ulysses, and his wariness of novels created with AI_"

https://www.theguardian.com/books/article/2024/jun/21/irvine-welsh-if-reading-gives-you-comfort-youre-not-doing-it-right

#Read #Reading #Book #Books #Ebook #Ebooks #Bookstodon @bookstodon

On Turing's birthday, the science of how alive you (really) are, from the children's field guide to wonder that shaped his mind, the mind that gave us the digital age https://t.co/7bzmoybjZz

"You might ask how AI generates something so completely bananas. It’s because AI can’t tell the difference between true and false. Instead, a complex computer program plays probabilistic language guessing games, betting on what words are most likely to follow other words. If an AI program hasn’t been trained on a subject — unusual last names, for instance — it can conjure up authoritative-seeming but false verbiage."

https://kansasreflector.com/2024/06/22/artificial-intelligence-has-spread-lies-about-my-good-name-and-im-here-to-settle-the-score/

Trials of a 4 day week have given clear results:

🟢Improved wellbeing
🟢Improved health
🟢Improved productivity
🟢Improved employee retention
🟢Reduced climate emissions

It's an idea whose time has come.

Unveiling India’s Lost Era: Proto-Sarada Script Sheds Light on Mysterious 6th–10th Century Transition
https://scitechdaily.com/unveiling-indias-lost-era-proto-sarada-script-sheds-light-on-mysterious-6th-10th-century-transition/ #archaeology #india #pakistan #buddhism #hinduism #Proto—Sarada

Mathematicians Accidentally Found a New Way to Represent Pi
https://www.sciencealert.com/mathematicians-accidentally-found-a-new-way-to-represent-pi #mathematics #pi #OptimizationProblem