Thiago Carvalho @cyrilpedia@qoto.org

"Our framework suggests that after accounting for heterogeneity, the probability that the tested hypothesis is true for the average population, design, and analysis path can be much lower than implied by nominal error rates of statistically significant individual studies." #MetaSci #Methodology 🧪

Heterogeneity in effect size e...

Interesting article comparing estimated power data from 2024 TdF GC contenders to the Froome/Team Sky TdF victories. Procycling has got a lot faster in those years and today's riders can push higher numbers.
#cycling #procycling

https://velo.outsideonline.com/road/road-racing/the-2024-tour-de-france-gc-contenders-would-have-destroyed-the-froome-era-team-sky-train/

'Kate Womersley was a medical student at Cambridge university, nervously dissecting her first cadaver, when she noticed an odd lacuna in her anatomy course handbook: there was no mention of breasts.'

https://www.ft.com/content/ce9895f9-8ead-4b43-b473-874aebabc0e6

'Reeve chronicles the alt-right’s rise in “Black Pill,” a chilling and insightful account of the throughline from dopey internet memes to Donald Trump’s 2016 victory, the seductions of QAnon and the storming of the Capitol. In Reeve’s telling, Charlottesville was the fulcrum between a before, when hateful ideologies were coalescing, largely out of view, and the after — which we now inhabit. If you want to understand why it increasingly feels like liberal democracy is failing, and why white supremacy, misogyny, antisemitism and homophobia are ascendant, read this book.'
https://www.nytimes.com/2024/07/30/books/review/ellen-reeve-black-pill.html

'Langerhans cell Histiocytosis (LCH) and Erdheim-Chester disease (ECD) are clonal myeloid disorders, associated with MAP-Kinase activating mutations and an increased risk of neurodegeneration. Surprisingly, we found pervasive PU.1+ microglia mutant clones across the brain of LCH and ECD patients with and without neurological symptoms, associated with microgliosis, reactive astrocytosis, and neuronal loss.'
#Preprint
https://www.biorxiv.org/content/10.1101/2024.07.30.605867v1

'Cheap and efficient assessment methods that can be used in distance education, such as unsupervised online tests, spread with the Covid-19 pandemic. Yet, with the pandemic now behind us, many such assessments that are vulnerable to cheating are still used more than they used to be by time-poor academics in cash-strapped universities.'
https://www.theguardian.com/australia-news/commentisfree/article/2024/aug/01/i-know-why-students-its-time-for-australian-universities-to-do-something-about-it?CMP=aus_bsky

'What's surprising is that these things don't go on to show the same toxicity to eukaryotic cells, and I have to say, I wouldn't have expected that, especially since the initial screens used eukaryotic DNA). But the degree of DNA-induced aggregation correlates quite well with the antibacterial activity (and for that matter, the degree of self-aggregation is a pretty good surrogate for the DNA-induced aggregation).'
https://www.science.org/content/blog-post/new-way-kill-bacteria

'The government should look at ways of making it easier for medics to adopt new life-saving innovations. A framework for sepsis and infection management, akin to those for heart attack and stroke, would also help. As Daniels notes, sepsis affects more people than heart attacks and claims more lives than strokes.'
https://www.ft.com/content/9537418a-8796-430f-8de9-fcc691240c5b

Genomes fm chimpanzee, bonobo, gorilla, Bornean orangutan, Sumatran orangutan, and siamang:
"We resolve challenging regions, such as the major histocompatibility complex and immunoglobulin loci, providing more in-depth evolutionary insights."
#Genomics #Immunology #Preprint
https://www.biorxiv.org/content/10.1101/2024.07.31.605654v1

moPPIt: De Novo Generation of Motif-Specific Binders with Protein Language Models https://www.biorxiv.org/content/10.1101/2024.07.31.606098v1.full.pdf+html

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#proteomics #prot-preprint