Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
@NicoleCRust @CoriBargmann @cyrilpedia
Listening this pod recalled this funny birdsite RT by @WiringtheBrain of #scicomm decades progression of covers maximally hyping genetics discoveries:
https://nitter.net/WiringTheBrain/status/1543328830705770496
'Immune response to the vaccine mRNA is the most literal example of “killing the messenger” that I can think of, short of the Spartan treatment of Darius’ envoys in 491 BC.'
cc @Caroline_Bartma
https://www.science.org/content/blog-post/curevac-comes-around
"The paper costume prints are mostly made from real costumes (with the exception of the long dress, which is a smaller scale model) , worn by actors in a film project and subsequently smashed, inked and printed on cotton paper."
Colograph by Madalena
Thiago Carvalho
boosted
Weekly #GeneRegulation digest 3:
🧬 Epigenomics of environmental influences (review) https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1010567
🧬 Multi-scale cis-regulatory code (review) https://www.sciencedirect.com/science/article/pii/S1097276522012151
🧬 RNA-mediated CTCF binding https://genome.cshlp.org/content/early/2023/01/17/gr.276643.122.abstract
🧬 How Pol II, BAF and TFs evict nucleosomes https://www.biorxiv.org/content/10.1101/2023.01.22.525083v1
🧬 Centromeres as hotspots of DNA breakage https://www.cell.com/molecular-cell/fulltext/S1097-2765(23)00004-7
🧬 Atlas of lamina-associated chromatin https://genomebiology.biomedcentral.com/articles/10.1186/s13059-023-02849-5
🧬 Histone-organized chromatin in bacteria https://www.biorxiv.org/content/10.1101/2023.01.26.525422v1
"The hope was that biosimilars would drastically drive down the cost of pricey brand-name biologics. That is what has happened in Europe. But it has not worked out that way in the United States."
https://www.nytimes.com/2023/01/28/business/humira-abbvie-monopoly.html
Thiago Carvalho
boosted
Mining #metatranscriptomes reveals a vast world of #viroid-like circular RNAs: Cell
'El objetivo de Tapola, como el de decenas de miles de profesores en Finlandia, es que los alumnos desarrollen el pensamiento crítico y la capacidad de verificar datos. La “alfabetización mediática” para contrarrestar la desinformación es una parte esencial del currículo escolar finlandés desde 2014, año de la anexión rusa de Crimea y del inicio de los combates en el este de Ucrania.'
Thiago Carvalho
boosted
Three of those four #lymphoma patients achieved a complete response with out-of-commercial specification (OOS) CAR T therapy
Risk factors for OOS were ≥ 4 prior therapies or previous bendamustine exposure.
#MEDMASTODON #Cancer
#ClinicalResearch #Oncology #Medicine #lymsm @majorajay
https://pubmed.ncbi.nlm.nih.gov/36111694/
Thiago Carvalho
boosted
“No matter what your story is, there is a place for you in science.”
New study finds that an intervention featuring personal and professional stories of diverse scientists increases students’ ability to relate to scientists, especially among first-generation college students and students who identify as female.
Open access: https://www.lifescied.org/doi/full/10.1187/cbe.22-06-0103
"This is an energetic approach for generations of Russian-speaking American Jews navigating a fraught historical identity, and also for artists and intellectuals who do not think immigrants owe America for their acculturation and citizenship, but rather that a complex, prosperous, artistic, and intellectual America is impossible without us."
Gary Shteyngart @nybooks
https://www.nybooks.com/articles/2023/02/09/beyond-the-pale-how-the-soviet-jew-was-made-senderovich/
Thiago Carvalho
boosted
'Noodle Restaurant on a Rainy Night' - Tokuriki Tomikichiro, 1951.
#ukiyoe #JapaneseArt #japodon
Thiago Carvalho
boosted
If you find this story enraging, realize that this kind of patent manipulation is common among pharmaceutical and biotech firms.
Thiago Carvalho
boosted
"The purpose of art is to lay bare the questions that have been concealed by the answers." — James Baldwin
#JamesBaldwin #BlackCulture #BlackArt #writingcommunity #writerscommunity #creativity #inspiration #writing #storytelling #screenwriting #writingtips #creativewriting #amwriting #writinglife
Thiago Carvalho
boosted
RT @doctorveera@twitter.com
Sharing GWAS summary statistics results in more citations
@GReales7@twitter.com @chr1swallace@twitter.com
https://www.nature.com/articles/s42003-023-04497-8
🐦🔗: https://twitter.com/doctorveera/status/1619372470808743937
You'll never guess what happened next...
"The key patent on the best-selling anti-inflammatory medication, used to treat conditions like arthritis, was expiring at the end of the year. Regulators had blessed a rival version of the drug, and more copycats were close behind. The onset of competition seemed likely to push down the medication’s $50,000-a-year list price."
#TNF #RheumatoidArthritis #lupus #PublicHealth #Humira #MonoclonalAntibody
https://www.nytimes.com/2023/01/28/business/humira-abbvie-monopoly.html
Thiago Carvalho
boosted
Indeed this is a great listening experience, food for thought and very inspiring !!! @cyrilpedia @CoriBargmann
@Rumpelstiltskin@mastodon.nz @lrb Thanks for the feedback, I need to get it
Thiago Carvalho
boosted
Print by Madalena & Constança Arouca
"Map 2 The Outer Hebrides Palimpsest (Edinburgh, Scotland, 1677)
This map is part of a series commissioned by King James VI during his attempt to pacify the “most barbarous Isle of Lewis”. It is of little strategic interest, as it charts two nearby uninhabited islets of no economic significance, but it has one unique feature: the engraver was clearly working from a palimpsest in vellum and decided to copy into the plate the still legible underlying text – a text which has absolutely no connection to the region depicted (it appears to be a list of penances compiled by the Observant Franciscan Friars of Aberdeen)."
If the NHS were on any more precipices, it would be Wile E. Coyote.
'The peers sent the findings of their inquiry into academic medicine to Steve Barclay, the health secretary, on Thursday, warning that “the clinical research environment in the NHS is on a dangerous precipice”.
https://www.ft.com/content/b5b9fe7f-7169-4ae6-a97b-cd98fe346ffe
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
