Thiago Carvalho @cyrilpedia@qoto.org

'Here, we show that in a mouse model of MS, T cell-specific Ahrknockout leads to recovery driven by a decrease in T cell fitness. At the mechanistic level, we demonstrate that the absence of AHR changes the gut microenvironment composition to generate metabolites that impact T cell viability, such as bile salts and short chain fatty acids.'

#Immunology #MucosalImmunology

Merchak et al @PLOSBiology

https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002000

Multiculturalism in Pamplona.

"One of the fundamental questions in biology is how the vast diversity of morphologies in organisms is generated. Today, it is well-accepted that similar genes fulfil similar functions in different organisms. However, more than 40 years ago it was still assumed that morphological differences between animals were controlled by very different genes."

https://www.nature.com/articles/s41580-023-00592-0

This is accurate

"Italo Calvino was, word for word, the most charming writer to put pen to paper in the twentieth century."

https://www.newyorker.com/magazine/2023/03/06/the-worlds-of-italo-calvino

ICYMI, it was a pleasure to interview Nobel-prize winning immunologist Tasuku Honjo about the story behind his lab's discovery of PD1, a classic @embojournal paper from 1992.
🎧 #EMBOPodcast #EMBOJournal #Immunology #immunotherapy #checkpointinhibitors #HistoryOfScience

https://www.embo.org/podcasts/from-cell-death-to-cancer-immunotherapy/

I don't think there is a way to convey online how cool these miniature etchings Madalena made are - they are almost postage stamp size in real life

#Etching #Printmaking #ArtMastodon

https://madalenaparreira.com

"Computational analysis of fetal haematopoietic tissues has uncovered trajectories for T and B cell differentiation across multiple organ sites, and how these trajectories might be dysregulated in fetal and paediatric health and disease."

#Immunology

https://onlinelibrary.wiley.com/doi/abs/10.1002/eji.202250222

In *2016*

"In short, medical students held unsubstantiated beliefs about anatomical and physiological differences between supposed “races.” Many of these students thought that Black skin was thicker than white, that Black individuals age more slowly than white, and that Black nerve endings were less sensitive than white."

https://nautil.us/the-misguided-history-of-racial-medicine-263508/?_sp=227fdb16-8a0a-4bd1-8c56-d52560f844ef.1677578073256

"The brain is three pounds of stuff. You can lay it on a table and probe it. But this sensation of consciousness is a subjective experience. There is a gap between the objective and subjective that makes it very difficult to understand how consciousness emerges from the material brain. I don’t have any answers, and I think philosophers and neuroscientists don’t yet have answers either. It’s really one of the most interesting fundamental questions in science."

https://lareviewofbooks.org/article/does-a-final-theory-exist-a-conversation-with-alan-lightman/

"Although we expect irrational behaviour and lapses of judgment from Alzheimer’s patients, we’re often puzzled by the baffling behaviour of caregivers themselves, many of whom mirror the denial, resistance, distortions, irrationality and cognitive lapses of the people they’re caring for."

https://www.theguardian.com/society/2023/feb/28/dinner-with-proust-how-alzheimers-caregivers-are-pulled-into-their-patients-worlds

"(...) the size and composition of the reviewer pool has not kept pace, say editors, because journals often favour well-known scientists from countries with established science infrastructures, rather than early-career researchers or scientists from emerging science nations."

https://www.nature.com/articles/d41586-023-00403-8