Thiago Carvalho @cyrilpedia@qoto.org

Last fall I spoke with @MarkHanson, who was then in Bruno Lemaitre's lab, for EMBO's @ReviewCommons platform for refereed #preprints. I love this detail about how flies grow - I picture a tiny little bicycle pump in there somewhere:

'When flies eclode from the pupa they are soft and squishy and they “manually” inflate their wings by pumping air through their body and that inflates the cuticle in a way that there is room for the body to move around inside that shell.'
#Drosophila #InnateImmunity

https://www.reviewcommons.org/blog/models-oddballs-and-preprints-a-conversation-with-mark-hanson/

@ct_bergstrom A colleague of mine told me that when he tested this, ChatGPT had a decent reference list, but scrambled the text (mixing and matching authors, titles, journals etc)

PNAS outlines its policy for the use of text generated by ChatGPT et al in papers. Not clear what the process will be if the AI is an Academy Member.

https://www.pnas.org/post/update/pnas-policy-for-chatgpt-generative-ai

@sara The glycine receptor? I'm not aware of any strong link between glycine receptor polymorphisms and type 1 diabetes - but that could just be my ignorance.

'Here, we show that in a mouse model of MS, T cell-specific Ahrknockout leads to recovery driven by a decrease in T cell fitness. At the mechanistic level, we demonstrate that the absence of AHR changes the gut microenvironment composition to generate metabolites that impact T cell viability, such as bile salts and short chain fatty acids.'

#Immunology #MucosalImmunology

Merchak et al @PLOSBiology

https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002000

Multiculturalism in Pamplona.

"One of the fundamental questions in biology is how the vast diversity of morphologies in organisms is generated. Today, it is well-accepted that similar genes fulfil similar functions in different organisms. However, more than 40 years ago it was still assumed that morphological differences between animals were controlled by very different genes."

https://www.nature.com/articles/s41580-023-00592-0

This is accurate

"Italo Calvino was, word for word, the most charming writer to put pen to paper in the twentieth century."

https://www.newyorker.com/magazine/2023/03/06/the-worlds-of-italo-calvino

ICYMI, it was a pleasure to interview Nobel-prize winning immunologist Tasuku Honjo about the story behind his lab's discovery of PD1, a classic @embojournal paper from 1992.
🎧 #EMBOPodcast #EMBOJournal #Immunology #immunotherapy #checkpointinhibitors #HistoryOfScience

https://www.embo.org/podcasts/from-cell-death-to-cancer-immunotherapy/

I don't think there is a way to convey online how cool these miniature etchings Madalena made are - they are almost postage stamp size in real life

#Etching #Printmaking #ArtMastodon

https://madalenaparreira.com

"Computational analysis of fetal haematopoietic tissues has uncovered trajectories for T and B cell differentiation across multiple organ sites, and how these trajectories might be dysregulated in fetal and paediatric health and disease."

#Immunology

https://onlinelibrary.wiley.com/doi/abs/10.1002/eji.202250222