Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
"Researchers who hold at least three grants from the National Institutes of Health (NIH) make up a growing portion of its grantees, according to a new study. White men predominate among these “super” principal investigators (PIs), with women and Black researchers much less likely to be part of this elite group."
https://www.science.org/content/article/women-black-researchers-less-likely-hold-multiple-nih-grants
Thiago Carvalho
boosted
RT @briscoejames
Our latest: Notochord and axial progenitor generation by timely BMP and NODAL inhibition during vertebrate trunk formation
Combining transcriptome analysis of vertebrate embryos & 2D+3D ES cell differentiation to study trunk formation & notochord generation
Thread...
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FDA panel votes on Pfizer and GSK RSV vaccines
"On Tuesday, the panel voted in favor of the Pfizer vaccine by 7 to 4, with one abstention, on its safety and efficacy. On Wednesday, it voted 10 to 2 in favor of the GSK vaccine’s safety and unanimously on the shot’s efficacy."
Thiago Carvalho
boosted
Winners of the 2022 World Nature Photography Awards—via @TheAtlPhoto: http://on.theatln.tc/1aX9GOD
Original tweet : https://twitter.com/TheAtlantic/status/1631149425857839105
Original tweet : https://twitter.com/TheAtlantic/status/1631149425857839105
Thiago Carvalho
boosted
Modeling & experimental analyses of a Golgi-localized GTPase circuitry that allows cancer cells to achieve self-sufficiency in growth factor signaling ➡️ http://bit.ly/41DK7Dj
P Rangamani & P Ghosh, UCSD
#Gproteins #CellSignaling #EGFR #SystemsBiology
Thiago Carvalho
boosted
Correction: An earlier version of this story failed to acknowledge Rosalind Franklin's crucial role in discovering the double helix structure of DNA. She produced the x-ray photograph used by Watson and Crick, and published a paper on her findings. https://t.co/uT7b0HBvxy
Preclinical study of anti-IL8 in endometriosis:
"We created a long-acting recycling antibody against IL-8 (AMY109) and evaluated its clinical potency. Because rodents do not produce IL-8 and do not experience menstruation, we analyzed the lesions in cynomolgus monkeys that spontaneously developed endometriosis and in a surgically induced endometriosis monkey model."
#Immunology #monoclonalantibodies #Endometriosis #inflammation
Thiago Carvalho
boosted
Thiago Carvalho
boosted
Origin and Evolution of Marsupial-specific Imprinting Clusters Through Lineage-specific Gene Duplications and Acquisition of Promoter Differential Methylation https://doi.org/10.1093/molbev/msad022 #science #evolution #biology #genome #SciComm #evolgen_paper
Thiago Carvalho
boosted
Mitonuclear Interactions and the Origin of Macaque Societies https://doi.org/10.1093/gbe/evad010 #science #evolution #biology #genome #SciComm #evolgen_paper
'Apart from trans-acting protein factors, recent evidence points to a role of different RNA species in targeting repressive histone marks and DNA methylation to these sites in mammals. Here, we review recent discoveries on this topic and predominantly focus on the role of RNA methylation, piRNAs, and other localized satellite RNAs.'
Thiago Carvalho
boosted
Gerhard Richter, Untitled from Canary Landscapes (Kanarische Landschaften), 1970–71 #museumarchive #museumofmodernart http://www.moma.org/collection/works/66509
"Smith was first and foremost an Enlightenment thinker who sought to empower humanity to reshape and reimagine the world. The utopian rigor of market thought would have cut against his entire method and approach to social and economic life—especially his democratic sensibilities, his feeling that there was no single order that could be imposed on all of society."
"Because of the important role of the ENS in controlling intestinal functions, it is not surprising that changes in ENS development and function are connected to intestinal microbiota dysbiosis in various human disorders"
https://journals.physiology.org/doi/full/10.1152/ajpgi.00166.2022
Thiago Carvalho
boosted
RT @CyrilPedia
My latest Clinical Pipeline column is out, a look at an anti-FcRn monoclonal for severe hemolytic disease of the fetus and newborn https://twitter.com/NatureMedicine/status/1630906381376135169
Thiago Carvalho
boosted
Online now: Can herbivores sharing the same host plant be mutualists? https://www.cell.com/trends/ecology-evolution/fulltext/S0169-5347(23)00026-5?rss=yes&utm_source=dlvr.it&utm_medium=mastodon
The Torremolinos model of human evolution:
"Like retirees who flock to the Costa del Sol, ancient European hunter-gatherers sought out Spain’s warmer climate during the peak of the last ice age."
'Here, we investigated the generality, specificity and mechanistic basis of immune priming in the fruit fly Drosophila melanogaster when infected with the gram-negative bacterial pathogen Providencia rettgeri.'
Thiago Carvalho
boosted
PNAS outlines its policy for the use of text generated by ChatGPT et al in papers. Not clear what the process will be if the AI is an Academy Member.
https://www.pnas.org/post/update/pnas-policy-for-chatgpt-generative-ai
Thiago Carvalho
boosted
Last fall I spoke with @MarkHanson, who was then in Bruno Lemaitre's lab, for EMBO's @ReviewCommons platform for refereed #preprints. I love this detail about how flies grow - I picture a tiny little bicycle pump in there somewhere:
'When flies eclode from the pupa they are soft and squishy and they “manually” inflate their wings by pumping air through their body and that inflates the cuticle in a way that there is room for the body to move around inside that shell.'
#Drosophila #InnateImmunity
https://www.reviewcommons.org/blog/models-oddballs-and-preprints-a-conversation-with-mark-hanson/
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
