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“I couldn’t say that this specific pattern of binding, or this specific expression of genes, is a causal determinant in the patient’s response to immunotherapy,” he explains.

Bhattacharya was stymied by the age-old dictum that correlation does not equal causation — a fundamental stumbling block in artificial intelligence (AI).'

nature.com/articles/d41586-023

"The cheap servant

It is against the law for black servants to live under the same roof as their employers. In a private home, servants would have a separate little room in the backyard. She lives on the edge of opulence, while her own world is bare. Newspapers are her carpet, fruit crates her chairs and table."

fm 'Ernest Cole’s photographs of 1960s South Africa during apartheid' in the FT

ft.com/content/9919a741-9115-4

'TIR has previously provided a general summary of how to write scientific reports/papers, as well as more detailed and specific advice on writing Figure legends and Materials & Methods sections. Now we turn our attention to the real food & drink of any manuscript: the Results section.'

totalinternalreflectionblog.co

'We generated personalized libraries of neoantigen–HLA capture reagents to single-cell isolate the T cells and clone their T cell receptors (neoTCRs). Multiple T cells with different neoTCR sequences (T cell clonotypes) recognized a limited number of mutations in samples from seven patients with long-lasting clinical responses.'

nature.com/articles/s41586-023

"Our model is based on experimental measurements of neuronal and muscle activity and assumes gap junctional coupling among muscle cells and calcium-dependent force generation by muscles. With these assumptions, we can robustly reproduce a basic set of Hydra’s behaviors."

pnas.org/doi/10.1073/pnas.2210

“A mi padre lo habían bajado al calabozo, pero a mi hermana la subieron a la secretaría y allí la violaron”, relató Josefina Lamberto a EL PAÍS en 2014, cuando viajó a Madrid desde Pamplona para sumarse, en el consulado argentino, a la causa abierta en Buenos Aires contra los crímenes del franquismo. Los vecinos habían escuchado los gritos de Maravillas, de 14 años. Unos campesinos la encontraron luego muerta, desnuda en un descampado. El cuerpo había sido atacado por los perros “y decidieron echar gasolina sobre los restos y quemarlos”

elpais.com/espana/2023-03-12/v

Today in dystopian UK news:

NHS — “Junior doctors paid lower hourly rate than workers to get at [popular fastfood restaurant]” theguardian.com/society/2023/m

Universities — “One in five students at top universities consider dropping out over cost of living. A quarter are regularly going without food and other essentials” theguardian.com/education/2023

Can the #UK please stop imitating [infamous southern European country]. No matter how well you do it, the sun won’t shine as much.

@enirenberg

They think masks can't stop aerosols or droplets but can stop CO2.

This is a real brain trust.

'Há novas polémicas envolvendo o mestrado integrado em Medicina da Universidade Fernando Pessoa (UFP), recentemente aprovado pela Agência de Avaliação e Acreditação do Ensino Superior (A3ES). Há médicos apontados como futuros orientadores dos estudantes cujos nomes integraram o processo de candidatura à sua revelia.'

publico.pt/2023/03/12/sociedad

RT @nickmmark
The usual anti-vax suspects are talking about a paper “proving masks raise CO2 to harmful levels.”

Well I read it and it’s a bunch of non clinical wackos who used the wrong equipment to accidentally measure end tidal CO2.

A debunking 🧵

1/

'One of the most striking aspects of the modern information environment, as many people have observed, is the almost total collapse of local and even regional news outlets. Where once every town or city of even minor consequence had a newspaper — with reporters who helped the community understand itself through their work — now there are large parts of the country that exist in news deserts, where there is little coverage of anything, from local government to local events.'

nytimes.com/2023/03/11/opinion

Probably good to be seen by infectious diseases clinicians if you have an enterococcal bacteremia

The real question to me is whether a good quality remote microbiology consult is as good.
#microbiology #IDMastodon #MedMastodon #AMR

clinicalmicrobiologyandinfecti

The Impact of Sample Size and Population History on Observed Mutational Spectra: A Case Study in Human and Chimpanzee Populations doi.org/10.1093/gbe/evad019 #science #evolution #biology #genome #SciComm #evolgen_paper

New posting! This is another one, focused on writing the sections of scientific (earlier postings in this series have focused on writing scientific reports as a whole, and more granular considerations of the writing of Figure legends and Materials & Methods sections).

As always, this represents "a" way and not "the" way, but I hope it's helpful. Comments/thoughts/feedback very welcome. 👍

totalinternalreflectionblog.co

On this day in 1976: Proto-oncogenes suggested to be part of genetic machinery of normal cells #ThisDayInBiotech

Co-evolution of viruses and mammalian hormone ligands (and their receptors)? An interesting concept. The former conceived by Mike Wallis in an essay (same issue of BioEssays).
#virology #evolution #hormones

onlinelibrary.wiley.com/doi/pd

This is a classic example of a completely cynical, dishonest removal of a public official purely for use as a prop in political campaigning. Read the whole thing & try to find an alternate explanation. nytimes.com/2023/03/11/us/poli

One can hope...

"The Nobel laureate Joseph Stiglitz, former first lady of South Africa and Mozambique Graça Machel and former UN secretary general Ban Ki-moon are among nearly 200 signatories to a letter calling on governments to “never again” allow “profiteering and nationalism” to come before the needs of humanity, in the wake of the coronavirus pandemic."

theguardian.com/global-develop

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