Thiago Carvalho @cyrilpedia@qoto.org

'We generated personalized libraries of neoantigen–HLA capture reagents to single-cell isolate the T cells and clone their T cell receptors (neoTCRs). Multiple T cells with different neoTCR sequences (T cell clonotypes) recognized a limited number of mutations in samples from seven patients with long-lasting clinical responses.'

#Immunology #immunotherapy #checkpointinhibitors

https://www.nature.com/articles/s41586-023-05787-1

From the dawn of time we came; moving silently down through the centuries, living many secret lives, struggling to reach the time of the Gathering; when the few who remain will battle to the last.

'Pot1 is a subunit of telomere capping complex that binds to the G-rich overhang and inhibits the activation of DNA damage checkpoints. In this study, we explore new functions of fission yeast Pot1 by using a pot1-1 temperature sensitive mutant'
@miguelgf et al

#telomeres #telomere

https://www.biorxiv.org/content/10.1101/2023.01.23.525167v1

'Vacuum tubes could allow systems to be reprogrammed; they could be used repeatedly and flexibly. The tubes made complex computations possible, but they were unwieldy, both prone to breakage and laborious to repair. ENIAC, the US army’s world-leading computer, introduced in 1946, used 18,000 vacuum tubes to calculate artillery trajectories faster and more accurately than any human. That made it revolutionary, but its utility was limited by the fact that it was the size of a room, and that whenever a single tube failed, which happened on average every two days, the whole machine broke down.'

https://www.lrb.co.uk/the-paper/v45/n06/john-lanchester/putting-the-silicon-in-silicon-valley

'The writer’s laptop, a MacBook Air, uses another ‘system on a chip’, Apple’s M2. That single chip contains 20,000,000,000 transistors. The laptop contains so many transistors that if the writer travelled back in time to 1983, he could give every single person on the planet a transistor radio and still have a billion of them left over.'

https://www.lrb.co.uk/the-paper/v45/n06/john-lanchester/putting-the-silicon-in-silicon-valley

'Wired reports that Twitter is planning to charge researchers a minimum of $504,000 a year to access less data than they used to get for free.'

https://twitterisgoinggreat.com

'A large-scale screening identifies an inhalable polymer nanoparticle formulation that safely and effectively delivers therapeutic mRNA molecules to the lungs of several animal species.'

https://www.nature.com/articles/s41563-023-01491-7

'Graham’s blue eyes lasered in on me. “This woman has untreated diabetes,” he said. “It’s caused her to have thousands of small strokes that have killed all these parts of her brain. That’s what’s causing her dementia.”

“I didn’t know it could do that,” I said—a response that revealed my ignorance. I’d never even looked up the symptoms of untreated diabetes; I had assumed that a patient would never grow this sick from a common and manageable disease.'

https://www.newyorker.com/science/annals-of-medicine/the-assumptions-doctors-make