Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
We just covered this paper at Journal Club and it is impressive:
"Tracking neural activity from the same cells during the entire adult life of mice". Nature #Neuroscience 2023
https://www.nature.com/articles/s41593-023-01267-x
Flexible implants such as this (and Neuralink's) are ideal because they move with the brain. An issue with this one is that it cuts lots of axons during implantation. But its longevity is amazing. And this study counts the gray hairs on mice!
"A panel of expert advisers to the Food and Drug Administration on Thursday endorsed #Paxlovid as a treatment for adults with Covid who are at high risk for progression to severe illness. The move is likely to lead to full approval of the drug, which has been available under emergency use authorization."
https://www.nytimes.com/2023/03/16/health/fda-paxlovid-covid.html
'The findings won’t fully silence the entrenched voices on either side of the origins debate. But the new analysis may offer some of the clearest and most compelling evidence that the world will ever get in support of an animal origin for the virus that, in just over three years, has killed nearly 7 million people worldwide.'
'We find that DYRK1A is essential for protection from viral infection through CSR, mediated by phosphorylation of MSH6. Furthermore, DYRK1A regulates Germinal Center seeding and subsequent effective clonal expansion through the attenuation of cell-cycle progression.'
'The genetic data was drawn from swabs taken from in and around the Huanan Seafood Wholesale Market starting in January 2020, shortly after the Chinese authorities had shut down the market because of suspicions that it was linked to the outbreak of a new virus. By then, the animals had been cleared out, but researchers swabbed walls, floors, metal cages and carts often used for transporting animal cages.'
https://www.nytimes.com/2023/03/16/science/covid-wuhan-market-raccoon-dogs-lab-leak.html
Thiago Carvalho
boosted
I’m curious about seminar attendance at other institutions. IME it’s always been difficult to get people to show up to hear a talk with all the time pressures, but many folk are complaining that “things are worse now”.
What’s your take? No change? Attendance is down - blame it on quiet quitting? Too many talks?
@xtaldave I packed artic gear for no reason!
Thiago Carvalho
boosted
📣 Documentation published for Second Helmholtz Reproducibility Workshop: "Love your data? Make it reproducible! A workshop on reproducibility in data science“
➡ Recordings and slides via: https://events.hifis.net/event/667/timetable/#20230214.detailed
#Reproducibility #DataScience #OpenScience #InternationalLoveDataWeek
@association
@HelmholtzOpenScienceOffice
@adswa
@HeidiSeibold
@schlauch
@AntoniaS
@LeaMariaFer(lmf)
Thiago Carvalho
boosted
excited to see this one by Carl Feng &colleagues: https://doi.org/10.1084/jem.20221392 #Tuberculosis #spatial #Bcells
Thiago Carvalho
boosted
Intermittent antibiotic treatment of bacterial biofilms favors the rapid evolution of resistance
@CommsBio by @usui_masaru et al from @ChrisBel70
with @jmGhigoLab
'Unlike Stephens, Tufekci actually did the homework and wrestled with the studies and the data itself. She didn’t rely on the reputation of the Cochrane Library to make her case. Her verdict is that “the evidence is relatively straightforward: Consistently wearing a mask, preferably a high-quality, well-fitting one, provides protection against the coronavirus.”'
@gregggonsalves Gonsalves in The Nation.
https://www.thenation.com/article/society/covid-masks-lab-leak-pundits/
Thiago Carvalho
boosted
"But over the past three years, the same group of pundits—who are all long on elite journalistic status and very short on actual training or experience in infectious diseases—have been able to centrally shape the debates on matters of profound importance. At the same time, scientists and public health experts are often cast as not to be trusted, captured by vested interests, lacking common sense, and out of touch with what most Americans think and believe." https://www.thenation.com/article/society/covid-masks-lab-leak-pundits/
Thiago Carvalho
boosted
We have recently found that #NK cell effector function is sexually dimorphic. How? Female NK cells in mice and human express higher levels of the epigenetic regulator #UTX, which escapes X-linked inactivation. UTX regulates the chromatin accessibility of #IFNg and #Csf2, making female NK cells more potent in response to #cytokines and #viral infection.
Thiago Carvalho
boosted
@Saligramalab that's great. Love how there's a mechanistic link from the gut microbiome.
Leaves in my mind the question of why tolerance isn't broken more often through such a mechanism. Presumably HLA restriction is one key reason, but there must be other steps to make autoimmunity still a relatively rare phenomenon.
Thiago Carvalho
boosted
#Great #paper -Cysteine carboxyethylation generates neoantigens to induce HLA-restricted autoimmunity https://www.science.org/doi/10.1126/science.abg2482#.ZBOCW62TV6c.twitter
Chef's kiss
"That is surely worth it just to preserve the lovely Icelandic word for computer: tölva, meaning number prophetess."
https://www.ft.com/content/262542a7-6616-4f4e-87b0-d0e39b27727f
Thiago Carvalho
boosted
RT @KurakuLabMSM
Egg yolk protein genes in the species that abolished egg-laying. https://doi.org/10.1093/gbe/evad028 - study led by Yuta Ohishi
#FrilledShark #ラブカ #Squalomix @Squalomix4earth
Journal cover at https://academic.oup.com/gbe
Thiago Carvalho
boosted
RT @forni_giobbe
Applications for the '23 (June 6-9) workshop *Evolution of genes and species at a large-scale* in Trento, Italy are open! Lectureres include @sabifo4 on Bayesian dating, @orotastabelli on systematic bias, and Benoît Morel on multy-copy gene trees. (1/2) https://sites.google.com/view/itaphylogeneticsworkshop/itaphy
"A US federal court recently ruled against requiring health insurers to cover HIV pre-exposure prophylaxis (PrEP) under the Affordable Care Act. For every 10% decrease in PrEP coverage resulting from this ruling among US men who have sex with men, we estimate an additional 1,140 HIV infections in the following year in that population."
@gregggonsalves et al
Thiago Carvalho
boosted
🏳️🌈
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
