Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
Thiago Carvalho
boosted
The Harlem Hellfighters were a predominantly Black regiment in WWI. They confronted racism even as they trained for war, brought jazz to France, and battled longer than any other American unit. They also won the Croix de Guerre for their bravery. The medals can be seen in the colourized photo.
Thiago Carvalho
boosted
In my latest Clinical Pipeline column for Nature Medicine, a look at iPSC therapy for heart failure.
"Heartseed is not the only company currently performing clinical trials with iPSC-derived cardiomyocytes. Help Therapeutics in China is also using an approach with allogeneic iPSC-derived cardiomyocytes, and Göttingen University is running a trial for patients with end- stage heart failure using engineered heart muscle composed of a mixture of iPSC- derived cardiomyocytes and stromal cells."
Thiago Carvalho
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Job alert:
@EMBOPress is recruiting a scientific editor for The @embojournal
The deadline is tomorrow (Mar 21)
Thiago Carvalho
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"Colograph
The works presented here are created with alternative materials rather than etched on copper. From squashed paper costumes to packaging and leather book covers, objects are inked with different processes, both intaglio and planographic. Scales vary and are usually life-size." by @madparreira #Prints #Handmade #BookArt
Thiago Carvalho
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Gerhard Richter, Seascape I (Seestück I), 1969 #museumarchive #museumofmodernart http://www.moma.org/collection/works/101596
Thiago Carvalho
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Tools
"To complement existing tools of small-molecule-based inhibitors, we present a highly potent, novel catalytically-driven glucocorticoid receptors degrader, KH-103, based on proteolysis-targeting chimera technology."
Thiago Carvalho
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From Carl June et al
"A fundamental limitation of T cell therapies in solid tumors is loss of inflammatory effector functions, such as cytokine production and proliferation. Here, we target a regulatory axis of T cell inflammatory responses, Regnase-1 and Roquin-1, to enhance antitumor responses in human T cells engineered with two clinical-stage immune receptors."
Thiago Carvalho
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Protip:
If you're working on the Great Immunological Novel, make sure your characters from the 70s say "suppressor T cells" and not "Tregs".
(fm Benjamin Dreyer's wonderful 'Dreyer's English).
Thiago Carvalho
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Thiago Carvalho
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Antisemitism on Twitter has more than doubled since Elon Musk took over the platform – new research.
In the days after Elon Musk took over Twitter in October 2022, the social media platform saw a “surge in hateful conduct,” which its then safety chief put down to a “focused, short-term trolling campaign.” New research suggests that when it comes to antisemitism, it was anything but.
Rather, antisemitic tweets have more than doubled over the months since Musk took charge, according to research at tech firm CASM Technology and the Institute for Strategic Dialogue think tank conducted. https://theconversation.com/antisemitism-on-twitter-has-more-than-doubled-since-elon-musk-took-over-the-platform-new-research-201830
Today, in every-cell-is-an-immune-cell:
"STING activation in platelets was a critical driver of sepsis-induced pathology. Platelet-specific STING deficiency suppressed platelet activation and granule secretion, which alleviated sepsis-induced intravascular thrombosis and NETosis in mice."
Yang et al @ImmunityCP
Thiago Carvalho
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Deer mice run comfortably at 25C, but as the temperature rises the tiny rodents begin to struggle and they begin overheating once the air temperature reaches 38C, which could be a big problem for the mini mammals in future climate scenarios #science #zoology #comparativephysiology #climatechange
https://journals.biologists.com/jeb/article/226/5/jeb245732/297090
You can read the full research at https://journals.biologists.com/jeb/article/226/5/jeb244847/297103
"Data is one more space where we need that attention to and cultivation of equality. We’ve lost sight of that. We’re still in this wild west, highly unregulated terrain where inequality is just piling up."
https://www.nytimes.com/interactive/2023/03/20/magazine/colin-koopman-interview.html
From 12/21: I spoke with Harmit Malik on the #EMBOPodcast about how he got started, mobile genetic elements, genomic defences, and (with @tlemberger) preprints.
"Just like many other important transitions in life, I think my transition from chemical engineering to biology was chaperoned by a fantastic mentor.
(...)
He made even dry topics seem very interesting - but when he was teaching about the Lac operon and the basic fundamentals of molecular biology I was completely transfixed. It became something that I felt I could not pass up the opportunity to see if this is something I could spend the rest of my career on."
Advice from David Tarlinton: read.
"One piece of advice that I did follow, although less and less as my time gets more and more allocated to other things, is to read. You have to read. You cannot be good at this without reading. And I understand just how much immunology has exploded in the last 10 years and the sheer range of things that just keep coming out as absolutely critical. But it's still important. And not just in the high-impact journals, because often what's in them is subject to all kinds of interpretations of what's fashionable. All the way down into the really solid journals, where there's still a great refereeing process and people are asking important questions and developing really solid answers. You just have to read."
https://onlinelibrary.wiley.com/doi/10.1111/imcb.12633#.ZBeBO9-ocxU.twitter
Thiago Carvalho
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Hi #EcoEvoSocial #ecoevo, since @officialSMBE has extended the deadline to nominate for the #SMBE23 Community Service Award, I'm nominating Alexis Simon for his outstanding contribution in establishing and running this server.
If you want to support this nomination, please DM me and I'll share a link to register your support. https://ecoevo.social/@marcrr/109998119281183593
Thiago Carvalho
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#DukeBrainJobs reminder! Come be a research associate in the @DukePsychNeuro lab of @TamarKushnir.
---
RT @TamarKushnir
It's not to late to apply to work with us at @DukePsychNeuro!
https://academicjobsonline.org/ajo/jobs/24425
https://twitter.com/TamarKushnir/status/1635392877303058433
Thiago Carvalho
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Bioinformatics PhD Student Position @sevin_turcan
Interested in bioinformatics and brain tumor biology? Come join us in #Heidelberg at @uniklinik_hd as a #bioinformatics PhD student!
#ScienceJobs #job #bioinformatics #heid...
https://jobrxiv.org/job/heidelberg-university-hospital-27778-bioinformatics-phd-student-position/?feed_id=41046
A very good movie, but if you've been waiting for Paul Schrader to make a comedy, be warned: this is not it.
"Colograph
The works presented here are created with alternative materials rather than etched on copper. From squashed paper costumes to packaging and leather book covers, objects are inked with different processes, both intaglio and planographic. Scales vary and are usually life-size." by @madparreira #Prints #Handmade #BookArt
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
