Thiago Carvalho @cyrilpedia@qoto.org

@domhenri But then again maybe not.

As the great Lily Tomlin put it, the trouble with the rat race is that even if you win, you're still a rat.

"This competitive system has deep consequences for research. To be successful, it is necessary to publish fast and often — publish or perish. As a result, researchers feel the need to market their result to the community, which leads to a sensationalist and inaccurate or misleading style of scientific reporting."

https://www.nature.com/articles/s41567-023-01970-3

"A potential mechanism for the failure of oral vaccines is the local outgrowth of RORγt+ regulatory T (Treg) cells in the small intestine that limits mucosal inflammation and immune reactivity but not systemic immune responses, since systemic infection is most dangerous to the host."

#Immunology #MucosalImmunology

https://www.cell.com/immunity/fulltext/S1074-7613(23)00087-0?rss=yes&utm_source=dlvr.it&utm_medium=twitter

"More and more scientists are realizing that animals, like people, are individuals: They have distinct tendencies, habits, and life experiences that may affect how they perform in an experiment. That means, some researchers argue, that much published research on animal behavior may be biased."

https://www.theatlantic.com/science/archive/2023/03/animal-behavioral-science-personalities/673432/

From Michael Gale's lab, a small molecule RIG-I agonist

"We have now determined direct binding of KIN1148 to RIG-I to drive expression of IFN regulatory factor 3 and NF-κB target genes, including specific immunomodulatory cytokines and chemokines. Intriguingly, KIN1148 does not lead to ATPase activity or compete with ATP for binding but activates RIG-I to induce antiviral gene expression programs distinct from type I IFN treatment"

#Immunology #InnateImmunity #drugdevelopment #drugdiscovery

https://journals.aai.org/jimmunol/article-abstract/doi/10.4049/jimmunol.2300026/263539/A-Small-Molecule-RIG-I-Agonist-Serves-as-an?redirectedFrom=fulltext

'We think of him painting the beautiful: Ginevra de’ Benci, Cecilia Gallerani and Salai glow with glossy hair and good bone structure. Yet alongside his fascination with youth and loveliness Leonardo was obsessed with irregular, diseased and aged faces whose “monstrous” distortions he drew with daunting precision.'

https://www.theguardian.com/artanddesign/2023/mar/15/mona-lisa-monstrous-grotesque-leonardo-da-vinci-national-gallery-ugly-duchess

'In a study published by the American Cancer Society in March, researchers estimated that in 2023, 153,000 people in the United States would be diagnosed with colorectal cancer. Of those cases, about 13 percent would be among people under 50 — representing a 9 percent increase in cases in this age group since 2020.'

https://www.nytimes.com/2023/03/20/well/colon-colorectal-cancer-symptoms-screening.html

Fundamental physics questions:

"Peanut Butter Stirs an Old Debate: To the T.S.A., What’s a Liquid?"

https://www.nytimes.com/2023/03/20/travel/tsa-peanut-butter-liquid-security.html