Thiago Carvalho @cyrilpedia@qoto.org

'When I saw that second MMWR, that changed my life. I said, “Oh my God, this is a brand new disease.” There’re no such thing as brand new diseases, but this is a brand new disease. I made a decision then that, again, even my mentors discouraged me from doing that. Because they’ve said, “Why? You’re on the peak of this incredible trajectory. What are you doing?” I said, “I’m going to turn around and pivot completely the direction of my career and focus entirely on studying this mysterious disease without a name.” That’s when I just laid down one spear and picked up another.'

https://www.nejm.org/doi/full/10.1056/NEJMp2300938?query=featured_home

Fauci's road not taken:

"You envisioned yourself hanging up your shingle on the East Side?"

https://www.nejm.org/doi/full/10.1056/NEJMp2300938?query=featured_home

'Before the Spitsbergen discovery, the oldest ichthyosaurs in the fossil record were from China, dated to about 248 million years ago. “The problem is, [they] already look like fish: long bodies, flippers, modified tail [with] a fin,” says Kear. “They’re living in water and they don’t come out of it.”

https://www.atlasobscura.com/articles/earliest-ichthyosaur-fossil-arctic

'El camino había sido muy largo. Los viajes a la clínica de reproducción asistida en Dinamarca, varios intentos, el desgaste físico, emocional y económico. Y por fin el nacimiento en Brescia (norte de Italia), en casa. Pero a la mañana siguiente, cuando fueron al registro, la pequeña tuvo que ser inscrita solo como hija de una de ellas y de un padre desconocido.'

https://elpais.com/sociedad/2023-03-25/el-limbo-de-las-familias-con-progenitores-homosexuales-en-italia-es-muy-humillante-te-obligan-a-declarar-en-falso.html

"The World Health Organization has urged African health authorities to step up monitoring and clinical care after Tanzania reported its first outbreak of the virulent Marburg virus."

#publichealth #Virology #marburg

https://www.ft.com/content/0fe6bbbb-6993-41c5-900a-77054e4dc4d0

Variants & MISC

"Across all the variant periods, the risk of ventricular dysfunction was highest among the patients hospitalized during the alpha+ period as compared with those during the ancestral period (35% vs. 28%, relative risk, 1.19; 95% confidence interval, 1.04 to 1.35)."

#SARSCoV2 #COVID #Covid19 #misc

https://www.nejm.org/doi/full/10.1056/NEJMc2215074?query=featured_home

"With IL-8-humanized mouse strain, we demonstrate that IL-8-producing CD4+ T, myeloid, and tumor cells orchestrate myeloid-derived suppressor cell infiltration and angiogenesis, which results in enhanced tumor growth but reduced ICB efficacy."

#Immunology #Immunotherapy #cytokine

https://www.cell.com/cancer-cell/fulltext/S1535-6108(23)00077-6?dgcid=raven_jbs_aip_email

"The particles in pigments are bulky and difficult for an immune cell’s enzymes to degrade. So when inks get gulped down by immune cells such as skin-dwelling macrophages—which spend their lives devouring pathogens, cellular debris, and other schmutz within just a teeny patch of flesh—it can transform into a microscopic version of gum. The pigment particles lodge themselves inside macrophages’ innards, refusing to be broken down. When ink is visible at the surface of the body, it’s not just interlaced among skin cells—it’s shining out from the bellies of macrophages that can’t digest it."

https://www.theatlantic.com/science/archive/2023/03/tattoo-science-immune-system-effects/673462/