Alternative medicine:
"When it came to the treatment of diseases, the ancient Romans had no shortage of magical remedies, several of which involved iron nails. To cure epilepsy, the first-century historian Pliny the Elder advised driving a nail into the ground at the spot where the afflicted person’s head lay at the start of the seizure. The Romans hammered nails into doors to avert plagues and pounded coffin nails into thresholds to keep nightmares at bay. Nails from tombs and crucifixions were sometimes even worn around the neck as talismans against fevers, malaria and evil spells."
https://www.nytimes.com/2023/03/25/science/archaeology-ancient-rome-tomb.html
"In 1965, six years after the invention of the transistor, Moore forecast in a magazine article that the number of transistors and other components on a chip would double every year for the next decade. The prediction, dubbed Moore’s Law by an Intel colleague, has come to exemplify the onrush of technological advance ever since."
https://www.ft.com/content/fd02fefd-5312-432a-b1df-9668b438443d
“There is substantial risk, even if you’ve gotten all the vaccines,” Bernard Black, a law professor at Northwestern University who studies health policy, told me. More than 300 people still die from COVID each day, and the overwhelming majority of them are older. People ages 65 and up are currently hospitalized at nearly 11 times the rate of adults under 50.'
https://www.theatlantic.com/health/archive/2023/03/older-adults-covid-health-quality-of-life/673507/
Tools (#preprint)
"Our platform is built around a commercial instrument and integrates the handling and transfer of samples to and from the instrument, autonomous control of the instrument's software, and the algorithmic generation of sorting gates, resulting in walkaway functionality."
"Tumor-associated neutrophil (TAN) effects on glioblastoma biology remain under-characterized. We show here that 'hybrid' neutrophils with dendritic features - including morphological complexity, expression of antigen presentation genes, and the ability to process exogenous peptide and stimulate MHCII-dependent T cell activation - accumulate intratumorally and suppress tumor growth in vivo."
The Onion absolutely nailing it (again)
@xtaldave They should make the most of these last small distinctions between heir headlines and reality...
rock music history
'Having “something to say” does not necessarily make it worth saying; nor does it make the way you say it worth hearing.'
I really enjoyed this piece in tQ about Roger Waters of Pink Floyd. If you've encountered him recently in the news, this article tracks his crankiness and crackpot ideology as an echo of him wresting control of the Floyd between DSOTM and The Final Cut.
https://thequietus.com/articles/32741-pink-floyd-dark-side-of-the-moon-final-cut
rock music history
@clathrin Great piece - the Final Cut is underrated & Gunner's Dream is a masterpiece (the cadence in "after the service when you're walking slowly to the car" makes you feel like you *are* walking towards the car).
"Understood as a form of erasure, decolonisation easily becomes an impossible or even undesirable task. But the problem with this interpretation is that it completely turns the meaning of decolonisation on its head. As I explained above, decolonisation entails first and foremost a profound and critical engagement with the colonial past, not its erasure."
https://aeon.co/essays/how-do-you-decolonise-the-english-language
'In Iraq and Kuwait they have become routine. Further west, even cities on the Red Sea such as Yanbu have seen 50°C. The Gulf is both at the centre of global hydrocarbon production and at the fore of its climatic effects. The average temperature rise in the region is already well over two degrees above pre-industrial levels.'
https://www.lrb.co.uk/blog/2023/march/fifty-degrees-in-the-persian-gulf
Following the delisting of MDPI's flagship journal IJERPH from Clarivate/Web of Science, I've penned a perspective. Hopefully helps folks understand where this came from & why it's such a big deal for #MDPI, and the implications moving forward.
For perspective: IJERPH publishes more articles/y than PLOS One. 📊
See: bit.ly/ClarivateMDPI
The natural history of untreated pulmonary tuberculosis in adults: a systematic review and meta-analysis - The Lancet Respiratory Medicine
#TB #tuberculosis
https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(23)00097-8/fulltext#%20
For Throwback Thursday, from our Darwin Exhibition catalogue (2009), a shout-out to the trio at the Naval Museum in Lisbon that built our HMS Beagle model, Paula Galrinho, José Galrinho, and José Lopes. The riggings were very accurate, so that the 1.61m (1:27) long model used up three kilometres of thread!
"In terms of acceptance delay, we find, again, that papers from Asia, Africa, and South America spend more time compared to other papers published in the same journal and the same year. Regression analysis of US-based papers reveals that Black authors suffer from the greatest delay."
Lemurs, glazed stoneware by @hunchbacksociety
"With IL-8-humanized mouse strain, we demonstrate that IL-8-producing CD4+ T, myeloid, and tumor cells orchestrate myeloid-derived suppressor cell infiltration and angiogenesis, which results in enhanced tumor growth but reduced ICB efficacy."
#Immunology #Immunotherapy #cytokine
https://www.cell.com/cancer-cell/fulltext/S1535-6108(23)00077-6?dgcid=raven_jbs_aip_email
'When I saw that second MMWR, that changed my life. I said, “Oh my God, this is a brand new disease.” There’re no such thing as brand new diseases, but this is a brand new disease. I made a decision then that, again, even my mentors discouraged me from doing that. Because they’ve said, “Why? You’re on the peak of this incredible trajectory. What are you doing?” I said, “I’m going to turn around and pivot completely the direction of my career and focus entirely on studying this mysterious disease without a name.” That’s when I just laid down one spear and picked up another.'
https://www.nejm.org/doi/full/10.1056/NEJMp2300938?query=featured_home
Translational Genomics Postdoctoral Scholar @ChrisMaher_Lab
Come join us at Washington University for a #bioinformatics #postdoc focusing on #cancer #genomics
#ScienceJobs #job #genomics #cancer #bioinformatics #postdoc #p...
https://jobrxiv.org/job/washington-university-27778-translational-genomics-postdoctoral-scholar/?feed_id=41400
Our paper on collective tissue rotations spearheaded by @tb_physics in collab with Yulong Han, @RicardAlert, Ming Guo and @CBroedersz is out in @NatureComms 👉https://www.nature.com/articles/s41467-023-37054-2
We show how active matter responds to curvature & determines collective cell migration; 🧵👇
---
RT @d_brueckner
🔥NEW PREPRINT🔥
How are collectively migrating cells constrained by the curvature & topology of 3D systems?
We discov…
https://twitter.com/d_brueckner/status/1453827305219006476
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com