Thiago Carvalho @cyrilpedia@qoto.org

It appears that the #Project2025 document available online has been edited. It still appears to be 922 pages and has the same contents page as before, but the material has been moved around so it no longer lines up with the content page and it's hard to search. I haven't determined how else it was changed.

'Even without exposure to antigens, some CARs increase proliferation and nutrient uptake in T cells. Using stable isotope tracers and mass spectrometry, we observed basal metabolic fluxes through glycolysis doubling and amino acid uptake overtaking anaplerosis in CAR-T cells harbouring a rituximab scFv, unlike other similar anti-CD20 scFvs.'
#Immunology #Immunotherapy #CARTcells
https://www.nature.com/articles/s42255-024-01034-7

'In this instalment of the series Great Art Explained, the UK curator, gallerist and video essayist James Payne details why, even as nudity was prevalent in the art of Manet’s era, the depictions of naked women in his paintings were radical for their unidealised style – and for the way they stare directly at the viewer, daring, per Payne, to defy the male gaze.'

https://aeon.co/videos/creating-art-that-was-aware-of-itself-and-the-viewer-made-manet-the-first-modernist

'Stimulator of IFN genes (STING) is a critical component of the innate immune system, playing an essential role in defending against DNA virus infections. However, the mechanisms governing basal STING regulation remain poorly understood. In this study, we demonstrate that the basal level of STING is critically maintained by hypoxia-inducible factor 1 (HIF-1)α through transcription.'
#Immunology #InnateImmunity
https://journals.aai.org/jimmunol/article-abstract/doi/10.4049/jimmunol.2400123/266986/HIF-1-Transcriptionally-Regulates-Basal-Expression?redirectedFrom=fulltext

OECD: Germany gets top marks on integration

A new OECD study has found Germany is successfully integrating migrants despite obstacles such as migrants often having little education.

https://www.dw.com/en/oecd-germany-gets-top-marks-on-integration/a-69584486

'Para que isso aconteça, o exemplo da Frente Popular original é ainda o melhor guia. É o foco no bem-estar das pessoas, na qualidade de vida e na capacidade de os empregados e trabalhadores terem rendimento suficiente para terem uma vida digna e confortável que terão de estar os objetivos que permitirão afastar a França do abismo de um colapso do Estado de direito, da democracia e dos direitos fundamentais.'
@ruitavares
https://expresso.pt/opiniao/2024-07-04-a-franca-frente-a-frente-71652e29

Coordinator, Clinical & Translational Collaborations

Cold Spring Harbor Laboratory

See the full job description on jobRxiv: https://jobrxiv.org/job/cold-spring-harbor-laboratory-27778-coordinator-clinical-translational-collaborations/?feed_id=77496

#ScienceJobs #hiring #research
https://jobrxiv.org/job/cold-spring-harbor-laboratory-27778-coordinator-clinical-translational-collaborations/?feed_id=77496

Researchers generate heat exceeding 1,800 degrees using incredible solar thermal trapping method: 'This is crucial'.

It takes a lot of heat, mostly from fossil fuels, to make steel, glass, ceramics, cement; ~ 25% of global energy consumption. Scientists in Zurich are using synthetic quartz to trap heat from the sun at temperatures > 1,000 C. Previously, solar heat could only be trapped up to about 170 C. The much higher heat can be used to smelt steel and cook cement.

https://www.thecooldown.com/green-tech/solar-heat-smelting-industry-eth-zurich/

UNESCO online event Wednesday, July 10 to announce the Global Diamond Open Access Alliance.

https://scienceeurope.org/events/announcing-the-global-diamond-open-access-alliance/

Date: 10th July 2024
Time: 15:00 – 16:10 CET / 9:00 - 10:10 am Eastern / 6:00 - 7:10 a.m. Pacific
Venue: Online
Registration link: https://shorturl.at/lZnyh

'Stanford, the SIO’s institutional home, denies that it is dismantling the unit and loudly proclaims its commitment to independent research. On the other hand, according to DiResta, the university has run up “huge legal bills” defending SIO researchers from harassment by Republican politicians and conservative conspiracy theorists, and may have decided that enough is enough.'
https://www.theguardian.com/commentisfree/article/2024/jun/29/closing-the-stanford-internet-observatory-will-edge-the-us-towards-the-end-of-democracy

Here's a different bird flying with a stickleback that it just snatched from the surface of Lake Washington.

Israeli Finance Minister Bezalel Smotrich’s plan to annex the West Bank would see over 60% of the territory becoming a part of Israel. But Palestinian experts say it is “already happening.”

https://mondoweiss.net/2024/06/israels-leaked-plan-for-annexing-the-west-bank-explained/

#Palestine #Israel #Gaza
@palestine @israel