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"The altered CD8+ T cell metabolism did not affect the expansion potential, but enhanced the granzyme B and IFN-γ production capacity. In vivo, memory CD8+ T cells cultured under low oxygen pressure provided protection against bacterial rechallenge. Taken together, our study indicates that strategies of cellular immune therapy may benefit from reducing oxygen during culture to develop memory CD8+ T cells with superior effector functions."

onlinelibrary.wiley.com/doi/ab

On Ralph Ellison, photographer.

"Judging the photographs of an artist who is not primarily a photographer raises a prickly question. Are you assessing the photos on their own merits or examining them to better understand the artist’s main work? With an artist like Degas, his photos can be regarded as preparatory sketches for paintings. But what happens when the artist is not a painter but a writer?"

"Without modern mechanised transportation and confronted by enormous distances and varying weather by season, the ancient perception of distance had to have differed from our own. A long-distance journey in the Roman Empire, it has been posited, was anywhere beyond five days’ reach: quite the departure from our current ideal of anywhere not accessible within a few hours by car, plane or train."

aeon.co/essays/the-roman-empir

Only a few days left until the #RecognizingPreprintReview event!
Help us to make this event even greater by filling out this 5-minute survey 👇
buff.ly/3EECp2l

We're collecting feedback on how researchers, funders, & editors might participate in preprint review.

"The endothelium is a vertebrate specific specialization of the circulatory system that enabled a critical new level of vasoregulation. The evolutionary origin of these endothelial cells is unclear. We hypothesized that Mir-126, an endothelial cell-specific microRNA may be informative."

biorxiv.org/content/10.1101/20

#xp it is out! (10 years after the Smurf phenotype) doi.org/10.1101/2022.11.22.517
Thanks to the Smurf-based two-phase ageing model, we show - in D. melanogaster - that the so-called transcriptional signature of ageing is mostly carried by the Smurf phase, the last phase of life, while the non-Smurf phase is associated with an increasing transcriptional noise.
We demonstrate here the importance of including the two-phase model in ageing studies.
Enjoy the read, feedbacks welcome!

50 WAYS TO LEAVE YOUR TWITTER

You just pin your last tweet, Pete,
Request your archive, Clive,
You don’t need a blue tick, Vic,
Just get yourself free.

Hop on the tusk, Gus,
You don’t need to delete much,
Except your DMs, Jen,
And get yourself free.

Use Debirdify, Di,
Provide some alt tags, Mags,
Add a content warning, Tim,
To post sensitively.

Remember to boost, Ruth
You don't need to deny truth,
Just drop off the perch, Dirk,
And get yourself free.
#VerseThurday #TwitterMigration #FediTips

RT @DreJoanneLiu@twitter.com

Measles is ‘imminent threat’ globally, WHO and CDC warn. They said 25 million children did not receive their first dose, while an additional 14.7 million children missed their second shot, marking a record high in missed vaccinations. washingtonpost.com/health/2022

🐦🔗: twitter.com/DreJoanneLiu/statu

We also have a large number of fully funded PhD studentships available at the moment. Come join our incredible community of researchers and contribute to world-leading research in microbiology and structural biology. Please direct enquiries to the individual members of staff

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#introduction: I am a cognitive neuroscientist at the Ernst Strüngmann Institute in Frankfurt, Germany. I like structure and beauty and somehow that draws me to #oscillations in the brain, mainly recorded with #electrophysiology.

when I have time, I like to make animations of concepts related to that: mnemai.org/demos

maybe starting on a new platform will allow for more playfulness again, which I enjoyed at lot in the beginning on twitter. 🙂

#CognitiveNeuroscience

RT @EvoBiomech
We are looking for an enthusiastic, curious & kind PhD candidate to join our team to work on foraging biomechanics in leaf-cutter ants in spring/fall 23. Fully funded (4y), with lots of freedom/possibility to contribute your own ideas. Details:
evo-biomech.ic.ac.uk/wp-conten
Please RT!

Hi, all! I'm a professor at U Oregon, and I love evolution and ecology, population genetics and genoimc data, spatial data and spatial processes, and using simulation to learn stuff. I also spend a bunch of time teaching statistics.

I'm aiming to do a little social media break, but we'll see what happens!

RT @LabWalz
We are very excited to share our work published in @iscience showing that increased soluble HLA in COVID-19 present a disease-related diverse #immunopeptidome. Great work of our lab member @AnnikaNel.
cell.com/iscience/fulltext/S25

I’m remembering that @stephenfry was a bright beacon in my earliest Twitter experience. How lovely to see him here now. mastodonapp.uk/@stephenfry/109

How to stop Killers from turning on each other?

Engineering CAR-NK cells with ‘don’t kill me’ ligands circumvents problem of trogocytosis-mediated fratricide.

nature.com/articles/s41591-022

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