Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
"Mendel was promoted unexpectedly to abbot in 1868 and rapidly found himself embroiled in legal cases involving the tax status of the monastery. He continued to do some science—meteorology and beekeeping being his two main interests—but his research was largely eclipsed by his administrative work."
Thiago Carvalho
boosted
Tumor-Infiltrating Lymphocyte Therapy or Ipilimumab in Advanced Melanoma
https://www.nejm.org/doi/full/10.1056/NEJMoa2210233
Thiago Carvalho
boosted
I am an Associate Professor at Católica Biomedical Research Centre #CBR, co-affiliated with Instituto Gulbenkian de Ciência #IGC, Portugal.
Our group works on Host-Microbe interactions, using #Drosophila, #Wolbachia, #microbiota, and #viruses.
I coordinate #SymbNET, a #EUHorizon2020 Twinning
network on Host-Microbe #Symbiosis, #Genomics and #Metabolomics (https://symbnet.eu).
Thiago Carvalho
boosted
One-day old zebrafish brain. Depth color-coded, mCherry-tagged histone #DevBio #Microscopy #zebrafish #Neuroscience
Thiago Carvalho
boosted
One of my favorite Twitter accounts was always Matthew Christopher's Abandoned America. Matthew closed up shop on Twitter and moved to Mastodon as @AbandonedAmerica. You should follow and support his work not only because we need more mid-size original content accounts here, but because his photos are FANTASTIC.
https://mastodon.social/@AbandonedAmerica/109452123378940711
"Detrimental combinations were associated with cytotoxic immune response in primary tumors, while metastases showed signs of immune evasion and ineffective antitumor immunity. On the contrary, beneficial combinations were associated with an active cytotoxic immune response only in metastatic samples."
Thiago Carvalho
boosted
RT @katestorey27@twitter.com
Innovative support for aspiring new PIs from the Company of Biologists - mentoring and opportunities to present your work https://twitter.com/briscoejames/status/1600460263672643584
🐦🔗: https://twitter.com/katestorey27/status/1600828571618103296
Thiago Carvalho
boosted
Wrote something about why it's good to delay getting (re)infected with Covid as long as possible... 1/5
I wrote a piece with @kityates@mas.for @TheConversationUK on this.
It's important to delay #Covid infection AND it's doable.
Full article here:
https://theconversation.com/covid-treatments-and-prevention-are-still-improving-so-the-longer-you-can-avoid-it-the-better-192140
Thiago Carvalho
boosted
Lecturer/Reader in Computational Cognitive Science @ University of Edinburgh (School of Informatics) https://elxw.fa.em3.oraclecloud.com/hcmUI/CandidateExperience/en/sites/CX_1001/job/5974 full time, open ended, closes 12th Jan
Thiago Carvalho
boosted
RT @folha
'Vou ter que sair da faculdade para voltar a trabalhar', diz bolsista após cortes na educação https://www1.folha.uol.com.br/educacao/2022/12/vou-ter-que-sair-da-faculdade-para-voltar-a-trabalhar-diz-bolsista-apos-cortes-na-educacao.shtml?utm_source=twitter&utm_medium=social&utm_campaign=twfolha
Thiago Carvalho
boosted
RT @pabloimmune
Happy to share our small contribution to the IgA2 mystery @MehandruLab @SinaiImmunol for now in preprint form in @medrxivpreprint https://www.medrxiv.org/content/10.1101/2022.12.03.22282315v1
"Here, Sarden et al. aimed to characterize the mechanism by which resistance to Af fails in some individuals. The authors found that an axis consisting of innate B1a cells, natural IgG antibodies, and neutrophils is essential for maintaining protection against Af infection in preclinical models. This axis can be disrupted by factors ranging from influenza A and SARS-CoV-2 infection to corticosteroid treatment. Importantly, the authors showed that re-establishing this axis, including by administration of Af¬-reactive antibodies, can protect mice, highlighting a potential treatment"
How did I not know about this movie?
"8. True Confessions (1981)
Duvall and Robert De Niro get the best out of each other in Ulu Grosbard’s intelligent movie, co-written by Joan Didion and John Gregory Dunne, and based on Dunne’s novel inspired by the Black Dahlia case. Duvall plays a tough LAPD detective in the 40s, haunted by a corrupt past that he has put behind him. His younger brother is De Niro’s idealistic young catholic priest, who receives donations from a somewhat shady businessman. A gruesome murder brings the two into a mutually anguished confrontation."
https://www.theguardian.com/film/2022/dec/08/robert-duvalls-20-best-performances-ranked
Thiago Carvalho
boosted
'Sadly, my colleagues and I were to become far more familiar with life-threatening parasitic infections. In the early years of the aids epidemic, I lost many of my patients to them. An aids patient’s devastated immune system might allow the parasite Toxoplasma gondii, carried by cats, to form brain abscesses; Cryptosporidium infection, which normally infests cattle, caused wasting from relentless diarrhea.'
https://www.newyorker.com/magazine/2022/12/12/in-praise-of-parasites
Thiago Carvalho
boosted
Amazing.
RT @FrezzaLab@twitter.com
Microbial predators form a new supergroup of eukaryotes | Nature https://www.nature.com/articles/s41586-022-05511-5
🐦🔗: https://twitter.com/FrezzaLab/status/1600539322196758529
Thiago Carvalho
boosted
The Department of Defense doesn't want this, but some want to go after vaccination for personal, political gain. This is a non-issue manufactured by bad people.
Thiago Carvalho
boosted
The lab is hiring a 3 year #postdoc for a new project aiming to use HUGE language datasets from digital therapy to (i) understand fundamentals of depression and its temporal dynamics and (ii) use these data to measure and predict responsiveness to therapy.
Thiago Carvalho
boosted
@NicoleCRust @complexsystems @cogneurophys @PessoaBrain @SussilloDavid @carlosbrody @Neurograce @neuralreckoning @tyrell_turing @DrYohanJohn @cian @WiringtheBrain @tdverstynen @neuralengine
For modeling complex behavior, I've been really excited about frameworks coming out of computer animation, such as Zhang et al 2018 "Mode-adaptive neural networks for quadruped motion control" https://dl.acm.org/doi/10.1145/3197517.3201366
The architecture and training protocol are relatively simple, but produce complex and qualitatively accurate behavior!
Of course this kind of network is not biologically plausible, but I think you can start from it and add more and more biology while preserving the ability to model complex motion. Combining this kind of model but using one of the models in this thread as a base could work well, for instance, or (as in my work) adding more realistic sensors and actuators for the network and seeing the limit of movement.
Thiago Carvalho
boosted
Hi all! I'm an Assistant Professor at Dickinson College in the chemistry department. I make new bioluminescent proteins, probes, and tools. I'm interested in better ways to teach Organic Chemistry. I saw that @bertozzi was here (my academic grandmother via Jenn Prescher, lol) and decided to join! Excited to become a part of science mastodon!
#introductions #chembio #chemicalbiology #bioluminescence #organic #python #glycotime
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
