Thiago Carvalho @cyrilpedia@qoto.org
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
From Kevin Foster and collaborators
"The order and identity of incoming symbionts is critical for health, but what determines the success of the assembly process remains poorly understood. Here we develop ecological theory to identify factors important for microbial community assembly. Our method maps out all feasible pathways for the assembly of a given microbiome—with analogies to the mutational maps underlying fitness landscapes in evolutionary biology."
#Microbiology #MucosalImmunology
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001116
Thiago Carvalho
boosted
Marrocos eliminar a Ibéria do mundial só pode ser um sinal
'Experts say the prevalence of middle-class professionals in the ranks of the extremists makes them a far bigger threat than the radical left Baader-Meinhof gang that terrorised Germany in the 1970s. “This is a form of terrorism that has emerged out of the mainstream of society,” says Sebastian Fiedler, a Social Democrat MP and police detective.'
https://www.ft.com/content/b7565be2-0130-4d1d-9ace-c3f4787775d8
That's how you start an abstract:
"In the beginning it was simple: we injected a protein antigen and studied the immune responses against the purified protein. This elegant toolbox uncovered thousands of mechanisms via which immune cells are activated. However, when we consider immune responses against real infectious threats, this elegant simplification misses half of the story: the infectious agents are typically evolving orders-of-magnitude faster than we are."
Thiago Carvalho
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Ada Lovelace, née Augusta Ada Byron, was born #OTD in 1815. A mathematician and the first published computer programmer, she offered a prescient vision of what computing would become.
Portrait: Margaret Sarah Carpenter (1836)
Thiago Carvalho
boosted
On this day in 1934: Howard M Temin born, won 1975 #NobelPrize for discovering reverse transciptase #ThisDayInBiotech
Thiago Carvalho
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This whole “Twitter Files” nonsense has made me realize that I need to *leak* my next research article instead of publishing it.
'For Henry James, our man in Italy, “There is something ridiculous in talking of Venice without making him almost the refrain.”
The year is 1882, the American writer is not yet 40, and the him is Vittore Carpaccio: the painter of the early Renaissance whose narrative cycles of Christian saints decorate churches and confraternities all around the maritime city.'
Thiago Carvalho
boosted
New #preprint about PENSA, our flexible #OpenSource software package for comprehensive and thorough investigation of biomolecular conformational ensembles:
https://arxiv.org/abs/2212.02714
In three real-world examples, we show how it can be used to understand an #enzyme mechanism, #DNA #forcefield parameters, and #signaling in an #opioid #receptor.
Please share widely with the #MolecularDynamics #simulation #CompChem #MolBio #StructuralBiology #GPCR communities!
Feedback and ideas are always welcome.
Thiago Carvalho
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Nice review covering transmission, pathogenesis of airborne viruses: “Airborne transmission of respiratory viruses” https://www.science.org/doi/full/10.1126/science.abd9149
Thiago Carvalho
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Impressive how vigorous, crisp, and sound Anthony Fauci is at age ~82. Such an important voice.
We need many more scientifically literate and powerful voices like this willing to go into government and public service around the globe.
From @sciencemagazine podcast:
https://podcasts.apple.com/pt/podcast/science-magazine-podcast/id120329020?l=en&i=1000589458084
"As we know, because we’ve gone through it several times, the problem comes a month or two later. There will be a massive wave of covid infections, and this means that there’s going to be a lot of people with heavy symptoms, and, inevitably, there will be some deaths—a lot more covid-related deaths than what China is used to. Does Xi then reinstate a very draconian lockdown? Does he go to some partial level of lockdown, but push through with it? It’s unclear at this point. Right now, the optics are good. There’s an opening. People are a little bit more satisfied, a little bit less frustrated. For the next month or so, it’s going to be good. But when China does get this massive wave of infection and hospitalization, what is Xi going to do?"
https://www.newyorker.com/news/q-and-a/why-xi-jinping-changed-his-mind-on-zero-covid
Thiago Carvalho
boosted
Thiago Carvalho
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We're not lion: The 2022 Comedy Wildlife Photography Awards are a good laugh
https://www.npr.org/sections/pictureshow/2022/12/10/1141604273/comedy-wildlife-photography-awards-funny-animals-photos
Thiago Carvalho
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The Bregenz Festival is famous for staging some of the most mind-blowing spectacles. Verdi’s opera, “A Masked Ball,” featured a stage that looked like a giant book being opened by a skeleton. The show took place in 1999 on Lake Constance in Bregenz, Austria. It astounds me every time I see it! What do you think?
#arts #skeleton #theatre #production #musical #opera #weird #followback #austria #theater #actor
Thiago Carvalho
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Scary how much this describes the current situation in Austria as well. We are about to get orbanized. Well, we've been about to get orbanized for a while...
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RT @TimothyDSnyder
Six years ago, I published a list of political advice following Trump's election, which became the pamphlet "On Tyranny." The history of #fascism was important in that advocacy. I wrote then that "post-truth is pre-fascism," which has proven true. https:…
https://twitter.com/TimothyDSnyder/status/1601231090274144257
Thiago Carvalho
boosted
1. Crows are super smart.
2. Crows can remember faces.
3. Crows have regional dialects.
4. Crows hold funerals for the deceased.
5. Crows make & use tools.
6. Crows hide their food.
7. Crows have the largest brain to body ratio of any bird. Their brain to body ration is bigger than humans.
8. A group of crows is called 'a murder of crows'.
Picture taken at Warriston Cemetery in Edinburgh.
#BirdPhotography #bird #Crow #WildlifePhotography #WildlifePhotographer #ScottishWildlife #potd
'Lebowitz remains a voracious reader, and spends hours browsing in bookshops. She owns roughly 12,000 books – she knows this because the last time she moved apartment, the movers insisted on counting them. Starved of new books during the 2020 lockdown, she resorted to using a friend’s Amazon account. To her irritation, she is now saddled with 200 books she would never have bought had she been able to pick them up and leaf through them in a store.'
Thiago Carvalho
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Some excellent graphics in this Reuters piece exploring the state of #InsectDecline & the extent of our knowledge.
"[Insects are] the fabric tethering together every freshwater & terrestrial ecosystem across the planet.”
"The world has lost 5%-10% of all insect species in the last 150 years... 250,000 and 500,000 species"
#SciComm #Insects #Entomology #biodiversity #InsectApocalypse #insectageddon
https://www.reuters.com/graphics/GLOBAL-ENVIRONMENT/INSECT-APOCALYPSE/egpbykdxjvq/
Thiago Carvalho
boosted
I am super excited about our latest @biorxivpreprint@twitter.com - a collaboration within @UM_Biopsych@twitter.com with Martin Sarter, headed up by twitterless grad stu Hanna Carmon -- Neuro-immune modulation of cholinergic signaling in an addiction vulnerability trait https://www.biorxiv.org/content/10.1101/2022.12.05.519158v1
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com
Joined Nov 2022
