#introduction Hi everyone! We're the team behind the preprint peer review platform Review Commons (https://reviewcommons.org). Review Commons provides journal-agnostic scientific peer-review of preprints submitted by their authors. Our reviews are made public and can be easily transferred to our partner journals, accelerating dissemination of peer review research and avoiding redundant rounds of peer review
'Through analysis of shared mutations in separate leukemias from a child with infant KMT2A-rearranged B-ALL relapsing as AML, we established that KMT2A rearrangement occurred in very early development, before hematopoietic specification, emphasizing that cell of origin cannot be inferred from the transcriptional state.'
#Advent Day12—Half way! To celebrate, we have #Drosophila phalerata, kuntzei & limbata: three similar-looking #quinaria group flies. The first two are common #fungus feeders http://dx.doi.org/10.14411/eje.2003.056 , while limbata likes rotten plants (including cucurbits https://link.springer.com/article/10.1007/BF00344998 ). These species have been studied for their nematodes https://onlinelibrary.wiley.com/doi/abs/10.1046/j.1570-7458.1997.00225.x , their courtship song https://link.springer.com/article/10.1007/BF02765556 , and recently their cellular immune response https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0188133 #Diptera #Entomology
Most clinical studies posted as @medrxivpreprint[s] and then published in a journal have concordant study characteristics, results, and final interpretations
77% of medRxiv preprints (n=1399) published in 2 years (median of 6 months after preprint posting)
Most preprints and subsequent publications had concordant sample sizes [86%]), primary end points [98%], primary end point results [81%], and final interpretation [96.2%]
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2799350
via lead author Josh Wallach
I’m looking for some *really big* (ideally millions of rows) biological datasets for a “Data Science in Biology” course.
Ideally they should be:
* archived with a DOI
* have an associated paper or two, with some cool questions
* be messy observational data, or collated across many studies
If you have any pointers, I’d be extremely grateful! Please boost!
'High on the list of suspects, thanks to the word of an art thief not involved in the heist named Joseph Géry Pieret: none other than Pablo Picasso and Guillaume Apollinaire. Confessing to his habit of purloining small items from the Louvre, which then took no great pains to protect the cultural assets within its walls, Pieret informed the police that he had sold a couple of small Iberian statues to a “painter-friend.” Pieret, writes Artsy’s Ian Shank, “had left a clue — a nom de plume in one of his published confessions, pulled straight from the writings of avant-garde poet Apollinaire. (As police would later discover, Pieret was in fact the writer’s former secretary.)”
'Amgen is close to a deal to acquire Horizon Therapeutics in a transaction worth as much as $20bn, according to sources familiar with the matter, as a sell-off in healthcare stocks creates attractive targets.
(...)
The takeover would give Amgen access to Horizon’s pipeline of drugs for rare autoimmune and inflammatory diseases, including its blockbuster treatment Tepezza.'
#DrugDiscovery #DrugDiscovery #Pharma #Amgen #Autoimmunity #Immunology
https://www.ft.com/content/3cace2fc-406d-496b-9060-0f68e8b93080
The Board of Directors at #Roche will propose Akiko Iwasaki, Sterling Professor of Immunobiology and Molecular, Cellular and Developmental Biology at Yale University, for election as new Board member at the Annual General Meeting in 2023. #viruses #LongCovid
Gene length bias strikes again (is everything in #bioinformatics biased by gene length, GC content, or both?):
Aging is associated with a systemic length-associated transcriptome imbalance
https://www.nature.com/articles/s43587-022-00317-6
#AgingBiology #GeneLength #GeneOntology
'But, by the end of 2019, ATI had collapsed. The company’s closure left Möllmann-Bohle and more than 700 other people alone with a complex implanted medical device. People using the stimulator and their physicians could no longer access the proprietary software needed to recalibrate the device and maintain its effectiveness. Möllmann-Bohle and his fellow users now faced the prospect of the battery in the hand-held remote wearing out, robbing them of the relief that they had found. “I was left standing in the rain,” Möllmann-Bohle says.'
https://www.nature.com/immersive/d41586-022-03810-5/index.html
***One week left to apply!***
Do you love structural #bioinformatics? Would you like to be based in a beautiful city & region, working with colleagues to make exciting new discoveries? Consider joining us in Lund University https://lu.varbi.com/en/what:job/jobID:564808/
#structuralbiology #alphafold2 #alphafold #AI #cryoEM #computationalbiology
Please share!
Musk’s anti-Fauci tweet is my breaking point; leaving the other app behind so might as well do an #introduction!
I’m an Associate Professor of #Immunology at the #UniversityofWashington in Seattle. My lab studies programmed cell death in the context of cancer, infection and autoimmunity. Check out OberstLab.org for more info.
Outside the lab, I spend as much time as I can outdoors: Biking, rock climbing, hiking and #birding with my wife and our Irish Water Spaniel Rufus. What a good boy!
Excited to start sharing our work on @Mastodon! Here's our latest - a new preprint lead by a very talented former MS student, Jonathan Chien.
In a tour-de-force of population analyses, Jonathan showed that ACC neurons extract and emphasize abstract representations of reward context - in this case the potential for gain or loss on each trial – and then code trial outcomes relative to these contexts.
Hi everyone! Just getting started with my mastodon account. I am a Scientific Editor @JExpMed, and I am looking forward to getting to know the mastodon science community!
A Trip Through New York City in 1911: Vintage Video of NYC Gets Colorized & Revived with Artificial Intelligence
https://www.openculture.com/2020/02/1911-video-of-new-york-city-colorized-with-machine-learning.html
Leaving twitter; harassment of public health officials
Today was the straw that broke the camel's back for me.
This morning Elon Musk tweeted that his pronouns were prosecute/Fauci.
You can’t study evolutionary biology under the roof of the Discovery Institute and you can’t have meaningful and productive scientific collaboration on a platform run by right-wing troll who denies science when its results are inconvenient to him and just simply to hear his audience cheer.
So here I am. Thanks @cyrilpedia for persevering with the mastodon-related tweets and lists of migrating tweeps. Much appreciated 🙏
Thrilled to share our new paper where we map healthy human kidney at the single cell resolution. We identify features of tissue-specific immunity & sex-based transcriptional programs
This true collaborative effort was made possible by the incredible patients & surgeons at #UHN. This work is a key reference for those examining immune and parenchymal cell states in various kidney pathologies or exploring regenerative medicine approaches
https://www.nature.com/articles/s41467-022-35297-z
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com