'SARS-CoV-2 infection has caused a major global burden. Despite intensive research, the mechanism and dynamics of early viral replication are not completely understood including the kinetics of formation of plus stranded genomic and subgenomic RNAs (gRNA and sgRNA) starting from the RNA from the first virus that enters the cell. We employed single-molecule RNA-fluorescence in situ hybridization (smRNA-FISH) to simultaneously detect viral gRNA and sgRNA in infected cells and carried out a time course analysis to determine the kinetics of their replication.'
An introduction after moving my account to neuromatch.social -
I'm a neuroscientist at #Cornell. My recent research focuses on psychoactive drugs such as #ketamine and #psychedelics. I want to know how these compounds act on #dendrites and cortical microcircuits to mediate behavioral effects.
Outside of the lab, I enjoy drinking a good cup of espresso and rock climbing with my kids.
#introduction #neuroscience #NeuroscienceMigration #ScienceMastodon
Folks, I'm an editor at #Conservation Biology and we are actively soliciting research papers that focus on "Diversifying Conservation" We want to create a special issue highlighting research from diverse voices, research that highlights #diversity (broadly defined) in conservation, and submissions that may be centered in non-western epistemologies. Abstracts due mid Feb, with research papers at the end of March. Hit me up for more details
How they built the wormhole in the lab and what it all means https://explore.themarginalian.org/post/703471363057451008/how-they-built-the-wormhole-in-the-lab-and-what-it
"Our recovery of nef proviral sequences from the lungs of all participants, albeit in limited numbers in some cases (in particular, participants 3, 5 and 7), confirms this organ as a site of long-term HIV persistence during ART."
https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1010613#sec006
I think I’m due for an #introduction! I’m an MD/PhD student at #uOttawa, doing my PhD in #neuroscience with Jean-Claude Béïque and Richard Naud. My work explores how uncertainty in reward feedback is processed in #prefrontal cortex, mainly in the context of #autism.
To do this, I use #behavior tasks in mice along with simultaneous in vivo two-photon calcium imaging. I also model #learning and #DecisionMaking using #ReinforcementLearning #RL.
Some of my other interests include patch clamp #ephys, post #stroke #synapse remodeling, #serotonin, #psychedelics and #consciousness.
Follow if you want to join me in finding and sharing interesting papers and ideas!
My lab in Toronto is still looking for a postdoc to hunt for Legionella phages. Two years of funding and the chance to work alongside academic and industrial partners. Metagenomics, synthetic biology... Spread the word, reach out if interested. (Motivated post-bacs may also be considered if they can commit to a 2 yr term.)
Important read. Neurodiversity brings exceptional creativity and discovery to our fields. https://www.nature.com/articles/d41586-022-04248-5?utm_campaign=nature-careers-newsletter&utm_medium=email&utm_edition=202212090500&utm_source=newsletter
Time for a proper #Introduction here: I am a #scientist working in #immunology. I am especially interested by how the immune system functions at barrier sites, during #autoimmunity, and how it is altered during #inflammation. I also strongly advocate for increasing scientific literacy, fighting #misinformation, promoting #equity , and prevent #ClimateChange
Active eosinophils regulate host defense and immune responses in colitis
https://www.nature.com/articles/s41586-022-05628-7
Richard, with the increasing migration of science Twitter to sites like Mastodon, what are the prospects for adding a Mastodon sharing option, and more importantly, adding Mastodon to Altmetric article metrics in bioRxiv and medrXiv? For obvious reasons, supporting science dissemination by sustainable, non-commercial social media sources seems more important than ever.
Base editing: therapy clears girl's incurable #cancer
Her cancer was aggressive. #Chemotherapy, ana bone-marrow transplant, were unable to rid it from her body. She entered int#clinicaltrial where #geneediting was used on #Tcells to attack her #leukaemia
https://bbc.in/3Yf9j1g
RT @LenartLab@twitter.com
We have an open position for a PhD student to study oogenesis in the jellyfish, Clytia hemisphaerica. https://www.mpinat.mpg.de/4277422/75-22
🐦🔗: https://twitter.com/LenartLab/status/1602334508539322369
In this new #NatureCommunications paper, we study 40-year trends of #insects in #Switzerland and relate them to the concurring changes in #LandUse and #Climate.
https://www.nature.com/articles/s41467-022-35223-3
Result of a research initiative with #Agroscope #WSL #FiBL #Vogelwarte #infofauna
#biodiversity #globalchange #butterfly #grasshopper #dragonfly #temporal #bayesian
Interesting and cool: Vertex Pharmaceuticals trying to reach the 5,000 Americans its cystic fibrosis drugs can't help with an experimental mRNA. FDA just gave go-ahead for first in humans studies.
Relevant today with the Horizon news: a pricey, ultra-orphan market.
last week to apply!
RT @gem__atkinson@twitter.com
Do you love structural #bioinformatics? Would you like to be based in a beautiful city & region, working with colleagues to make exciting new discoveries? Consider joining us in Lund University https://lu.varbi.com/en/what:job/jobID:564808/
#structuralbiology #alphafold2 #alphafold #AI
Please share!
🐦🔗: https://twitter.com/gem__atkinson/status/1598234355859881984
'Critics have long contended that the NIH perpetuates reputational bias in its review process, which has led to funding disparities among grant recipients. According to a 2022 NIH analysis, the 10% of institutions that receive the most money from the agency get about 65% of its overall funding for research projects, and the bottom half receives less than 5%. These proportions have remained persistent for years.'
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com