Show newer

I’m a #cognitive and human #neuroscientist at #CarnegieMellon studying #logic and #concepts across species, age, and culture to try to find out #whatmakesushuman.
A few years ago, when I worked at a different university, a bunch of us were whistleblowers and it caused the president of the university to resign #metoo

#introduction I am an assistant professor at the University of Rhode Island. I study spinal cord physiology and pathophysiology. My specialty is intracellular recordings of spinal motoneurons in vivo.
I am a pro #OpenScience and #OpenSource #FOSS. I love to write software (badly) and tinker with electronics (generally until the magic smoke comes out).

A fantastic group of authors, spearheaded by the amazing
@RebeccaSenft and Barbara Diaz-Rohrer
, have a new preprint for your end-of-year-reading lists! In the 🧵, learn a bit more about "A biologist's guide to the field of quantitative bioimaging"
zenodo.org/record/7439284#.Y5s 1/x

Thrilled to finally have our paper looking at the role of spatial structure in polymicrobial infections out today in @PNASNews! pnas.org/doi/10.1073/pnas.2212
#ChronicWounds #MRSA #Pseudomonas #SpatialStructure

Many years later--in fact, not until 1983--McClintock would win the #NobelPrize for her discovery of mobile genetic elements and gene transposition. Here's McClintock holding an ear of maize:

[pic from en.wikipedia.org/wiki/Barbara_]

Show thread

OK, this is an experiment posting longer pieces to #ScienceMastodon, so consider this 1/n.

I wanted to share a fascinating piece of #ScienceHistory that I stumbled across not long ago while rummaging through old papers from early #genetics labs at the University of Texas. Deep in boxes of classic reprints, I found correspondence between Barbara McClintock, the famed Cold Spring Harbor labs maize geneticist, and UT fly geneticist Wilson Stone.

The Nobel Prize was awarded for McClintock's work in the 1940's/50's characterizing mobile genetic loci in maize that she named Dissociation (Ds) and Activator (Ac) & how they contributed to the variable colors of maize kernels. She got such strong pushback that, in 1953, she stopped publishing altogether on this work.

The two letters I found date to the year before, 1952, and they're a lovely little treasure trove to a geneticist. Here they are in their entirety:

Show thread

Tools

"We propose a statistical approach, CS-CORE, for estimating and testing cell-type-specific co-expressions, built on a general expression-measurement model that explicitly accounts for sequencing depth variations and measurement errors in the observed single cell data."

biorxiv.org/content/10.1101/20

Let’s take a moment and share the new and incredible US Postal Service Stamp honoring John Lewis while everyone is talking about Trump’s shitty cards.

'About 300 miles away, at a hospital outside Flint, Mich., similar scenes were unfolding. Chronic understaffing meant that patients languished in dried feces, while robots replaced nursing assistants who would normally sit with mentally impaired patients.

Both hospitals are owned by one of the country’s largest health systems, Ascension. It spent years reducing its staffing levels in an effort to improve profitability, even though the chain is a nonprofit organization with nearly $18 billion of cash reserves.'

nytimes.com/2022/12/15/busines

"In this review, we discuss the current developments in elucidating the role of the Drosophila Toll signaling pathway in immunity. We discuss the emerging role of Toll in viral infections and sex-specific differences in immunity. Mainly, we focus on Toll pathway regulation, the effector molecules, and cellular immunity"

journals.aai.org/jimmunol/arti

Continuing the holiday celebration on Day 2 (of 10). Topic: Modern and fascinating ideas about the brain for us all to discuss. How likely is each idea to be true? And if true, what are the implications?

Brain idea 9: Across different individuals, the same brain functions are implemented by biological details that vary a lot. This is true even for simple circuits like the ones that control the stomach of a crab, where the numbers of ion channels can vary 2-6x across different crabs but the circuit always does the same thing.

The friendly version:
quantamagazine.org/eve-marder-

The deeper dive:
sciencedirect.com/science/arti

#neuroscience
(And because I'm trying to work out the hashtag habit here ...)
#BrainIdeasCountdown

Physicist Freeman Dyson was born #OTD in 1923.

He was known for his work in quantum electrodynamics and – among many other things – his eschatological musings about physics and the prospects for life in the far-flung future.

To the best of my knowledge, Dyson was the most prominent physicist of the modern era who never completed a PhD.

Photo: Heka Davis / AIP

Agree with paper presenting #EBI resources: #biocuration and #metadata are critical for "training sets for deep learning, machine learning and artificial intelligence applications" in the life sciences #bioinformatics #machinelearning
academic.oup.com/nar/advance-a

A mob of red deer stags in Richmond Park, they were on the edge of the woods and unless you stopped to look from most angles they were perfectly hidden, I crouched down to take the shot, that's when I could see how many there were (shot with a long lens it looks like I was a lot closer than I actually was). #RichmondPark #RedDeer #Stags #RedStags #WildLifePhotography #Nature #Photography #AltText

A small study in France showed a 10% vaccine failure rate in people who got a single dose of #mpox vaccine after an exposure event. People who developed the infection had mild symptoms. In Eurosurveillance. eurosurveillance.org/content/1

RT @yule_wu@twitter.com

I am thrilled that my PhD work is now published in Nature Methods. In @JonasRies@twitter.com Ries group at @EMBLHeidelberg@twitter.com , I developed a new tool to extract meaningful parameters from macromolecular structures in SMLM data. nature.com/articles/s41592-022

🐦🔗: twitter.com/yule_wu/status/160

Show older
Qoto Mastodon

QOTO: Question Others to Teach Ourselves
An inclusive, Academic Freedom, instance
All cultures welcome.
Hate speech and harassment strictly forbidden.