I’m a #cognitive and human #neuroscientist at #CarnegieMellon studying #logic and #concepts across species, age, and culture to try to find out #whatmakesushuman.
A few years ago, when I worked at a different university, a bunch of us were whistleblowers and it caused the president of the university to resign #metoo
#introduction I am an assistant professor at the University of Rhode Island. I study spinal cord physiology and pathophysiology. My specialty is intracellular recordings of spinal motoneurons in vivo.
I am a pro #OpenScience and #OpenSource #FOSS. I love to write software (badly) and tinker with electronics (generally until the magic smoke comes out).
#MastodonNews Dec 15, 2022
Forbes: Twitter Suspends Accounts For Rival Mastodon And Several High-Profile Journalists >>> https://www.forbes.com/sites/nicholasreimann/2022/12/15/twitter-suspends-accounts-for-rival-mastodon-and-several-high-profile-journalists/
Business Insider: Musk's Twitter is blocking links to its competitor Mastodon >>> https://www.businessinsider.com/twitter-blocks-links-to-mastodon-competitor-elon-musk-2022-12
Bloomberg.com: Twitter Suspends Accounts of Mastodon, Journalists Covering Musk >>> https://www.bloomberg.com/news/articles/2022-12-16/twitter-suspends-accounts-of-mastodon-journalists-covering-musk
Techdirt: Elon's... Blatant Hypocrisy >>> https://www.techdirt.com/2022/12/15/elons-commitment-to-free-speech-rapidly-replaced-by-his-commitment-to-blatant-hypocrisy-bans-the-joinmastodon-account/
#twittermigration
More News >>> https://medium.com/@mastodonmigration/sharing-advice-and-assisting-with-the-great-mastodon-migration-53c1a286b805#cfd1
Ovarian cancer mutational processes drive site-specific immune evasion https://www.nature.com/articles/s41586-022-05496-1
A fantastic group of authors, spearheaded by the amazing
@RebeccaSenft and Barbara Diaz-Rohrer
, have a new preprint for your end-of-year-reading lists! In the 🧵, learn a bit more about "A biologist's guide to the field of quantitative bioimaging"
https://zenodo.org/record/7439284#.Y5s_POzMI0R 1/x
Thrilled to finally have our paper looking at the role of spatial structure in polymicrobial infections out today in @PNASNews! https://www.pnas.org/doi/10.1073/pnas.2212340119
#ChronicWounds #MRSA #Pseudomonas #SpatialStructure
Many years later--in fact, not until 1983--McClintock would win the #NobelPrize for her discovery of mobile genetic elements and gene transposition. Here's McClintock holding an ear of maize:
[pic from https://en.wikipedia.org/wiki/Barbara_McClintock#/media/File:McClintock.jpg]
OK, this is an experiment posting longer pieces to #ScienceMastodon, so consider this 1/n.
I wanted to share a fascinating piece of #ScienceHistory that I stumbled across not long ago while rummaging through old papers from early #genetics labs at the University of Texas. Deep in boxes of classic reprints, I found correspondence between Barbara McClintock, the famed Cold Spring Harbor labs maize geneticist, and UT fly geneticist Wilson Stone.
The Nobel Prize was awarded for McClintock's work in the 1940's/50's characterizing mobile genetic loci in maize that she named Dissociation (Ds) and Activator (Ac) & how they contributed to the variable colors of maize kernels. She got such strong pushback that, in 1953, she stopped publishing altogether on this work.
The two letters I found date to the year before, 1952, and they're a lovely little treasure trove to a geneticist. Here they are in their entirety:
Tools
"We propose a statistical approach, CS-CORE, for estimating and testing cell-type-specific co-expressions, built on a general expression-measurement model that explicitly accounts for sequencing depth variations and measurement errors in the observed single cell data."
https://www.biorxiv.org/content/10.1101/2022.12.13.520181v1?med=mas
'About 300 miles away, at a hospital outside Flint, Mich., similar scenes were unfolding. Chronic understaffing meant that patients languished in dried feces, while robots replaced nursing assistants who would normally sit with mentally impaired patients.
Both hospitals are owned by one of the country’s largest health systems, Ascension. It spent years reducing its staffing levels in an effort to improve profitability, even though the chain is a nonprofit organization with nearly $18 billion of cash reserves.'
https://www.nytimes.com/2022/12/15/business/hospital-staffing-ascension.html
"In this review, we discuss the current developments in elucidating the role of the Drosophila Toll signaling pathway in immunity. We discuss the emerging role of Toll in viral infections and sex-specific differences in immunity. Mainly, we focus on Toll pathway regulation, the effector molecules, and cellular immunity"
Continuing the holiday celebration on Day 2 (of 10). Topic: Modern and fascinating ideas about the brain for us all to discuss. How likely is each idea to be true? And if true, what are the implications?
Brain idea 9: Across different individuals, the same brain functions are implemented by biological details that vary a lot. This is true even for simple circuits like the ones that control the stomach of a crab, where the numbers of ion channels can vary 2-6x across different crabs but the circuit always does the same thing.
The friendly version:
https://www.quantamagazine.org/eve-marder-on-the-crucial-resilience-of-neurons-20210517/
The deeper dive:
https://www.sciencedirect.com/science/article/pii/S0959438822001040
#neuroscience
(And because I'm trying to work out the hashtag habit here ...)
#BrainIdeasCountdown
Physicist Freeman Dyson was born #OTD in 1923.
He was known for his work in quantum electrodynamics and – among many other things – his eschatological musings about physics and the prospects for life in the far-flung future.
To the best of my knowledge, Dyson was the most prominent physicist of the modern era who never completed a PhD.
Photo: Heka Davis / AIP
Agree with paper presenting #EBI resources: #biocuration and #metadata are critical for "training sets for deep learning, machine learning and artificial intelligence applications" in the life sciences #bioinformatics #machinelearning
https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkac1098/6880745
A mob of red deer stags in Richmond Park, they were on the edge of the woods and unless you stopped to look from most angles they were perfectly hidden, I crouched down to take the shot, that's when I could see how many there were (shot with a long lens it looks like I was a lot closer than I actually was). #RichmondPark #RedDeer #Stags #RedStags #WildLifePhotography #Nature #Photography #AltText
FDA approves first drug to delay type 1 diabetes @cyrilpedia https://www.nature.com/articles/d41591-022-00115-y
A small study in France showed a 10% vaccine failure rate in people who got a single dose of #mpox vaccine after an exposure event. People who developed the infection had mild symptoms. In Eurosurveillance. https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2022.27.50.2200882?emailalert=true
RT @yule_wu@twitter.com
I am thrilled that my PhD work is now published in Nature Methods. In @JonasRies@twitter.com Ries group at @EMBLHeidelberg@twitter.com , I developed a new tool to extract meaningful parameters from macromolecular structures in SMLM data. https://www.nature.com/articles/s41592-022-01676-z
I've worked on all of science, from B cells to T cells.
https://fellowsherpa.com